RRG7_YEAST
ID RRG7_YEAST Reviewed; 242 AA.
AC Q08774; D6W305;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Required for respiratory growth protein 7, mitochondrial;
GN Name=RRG7; OrderedLocusNames=YOR305W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP DISRUPTION PHENOTYPE.
RX PubMed=16234568; DOI=10.1093/jnci/dji316;
RA Dilda P.J., Don A.S., Tanabe K.M., Higgins V.J., Allen J.D., Dawes I.W.,
RA Hogg P.J.;
RT "Mechanism of selectivity of an angiogenesis inhibitor from screening a
RT genome-wide set of Saccharomyces cerevisiae deletion strains.";
RL J. Natl. Cancer Inst. 97:1539-1547(2005).
RN [6]
RP DISRUPTION PHENOTYPE.
RX PubMed=19751518; DOI=10.1186/gb-2009-10-9-r95;
RA Merz S., Westermann B.;
RT "Genome-wide deletion mutant analysis reveals genes required for
RT respiratory growth, mitochondrial genome maintenance and mitochondrial
RT protein synthesis in Saccharomyces cerevisiae.";
RL Genome Biol. 10:R95.1-R95.18(2009).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095}.
CC -!- DISRUPTION PHENOTYPE: Impaired respiratory growth and sensitivity to 4-
CC (N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO).
CC {ECO:0000269|PubMed:16234568, ECO:0000269|PubMed:19751518}.
CC -!- MISCELLANEOUS: Present with 1420 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the RRG7 family. {ECO:0000305}.
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DR EMBL; Z75213; CAA99624.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA11071.1; -; Genomic_DNA.
DR PIR; S67209; S67209.
DR RefSeq; NP_014950.1; NM_001183725.1.
DR AlphaFoldDB; Q08774; -.
DR BioGRID; 34694; 26.
DR DIP; DIP-4068N; -.
DR MINT; Q08774; -.
DR STRING; 4932.YOR305W; -.
DR MaxQB; Q08774; -.
DR PaxDb; Q08774; -.
DR PRIDE; Q08774; -.
DR EnsemblFungi; YOR305W_mRNA; YOR305W; YOR305W.
DR GeneID; 854482; -.
DR KEGG; sce:YOR305W; -.
DR SGD; S000005832; RRG7.
DR VEuPathDB; FungiDB:YOR305W; -.
DR eggNOG; ENOG502RZ1Q; Eukaryota.
DR HOGENOM; CLU_085105_1_0_1; -.
DR InParanoid; Q08774; -.
DR OMA; PLIYLRV; -.
DR BioCyc; YEAST:G3O-33789-MON; -.
DR PRO; PR:Q08774; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q08774; protein.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR InterPro; IPR018828; DUF2034.
DR PANTHER; PTHR28133; PTHR28133; 1.
DR Pfam; PF10356; DUF2034; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome.
FT CHAIN 1..242
FT /note="Required for respiratory growth protein 7,
FT mitochondrial"
FT /id="PRO_0000245286"
SQ SEQUENCE 242 AA; 27967 MW; 05B0A91A7DCCA30B CRC64;
MIKNYLGRRW LNNPAIQAYV KQNAAVAHST VFQGNLYEYT VMRELSEKLR MTKLRKTGGA
HDGGVDIKGS WPVDDIYWKI SSLMPNLEMA SNIKRTNSQN GFVLKPLKYR IIDHTFEPLK
VLVQCKAFTK SKLSPREFRE LVGTFTSLVS HSQRNKTVCI MCSPHMLTKD TLNLINNITL
PLIYLRVEML KEKTDGHFDL INSGKLINYY ENSYASTLMQ DCKISEWLKL KLYKNSDFNS
EK
