AVT6E_ARATH
ID AVT6E_ARATH Reviewed; 489 AA.
AC Q9M8L9;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Amino acid transporter AVT6E {ECO:0000305};
DE Short=AtAvt6E {ECO:0000303|PubMed:27925655};
GN Name=AVT6E {ECO:0000303|PubMed:27925655};
GN OrderedLocusNames=At1g80510 {ECO:0000312|Araport:AT1G80510};
GN ORFNames=T21F11.16 {ECO:0000312|EMBL:AAF27127.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, NOMENCLATURE, AND SUBCELLULAR LOCATION.
RX PubMed=27925655; DOI=10.1002/1873-3468.12507;
RA Fujiki Y., Teshima H., Kashiwao S., Kawano-Kawada M., Ohsumi Y.,
RA Kakinuma Y., Sekito T.;
RT "Functional identification of AtAVT3, a family of vacuolar amino acid
RT transporters, in Arabidopsis.";
RL FEBS Lett. 591:5-15(2017).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:27925655}; Multi-pass membrane protein
CC {ECO:0000255}. Vacuole membrane {ECO:0000269|PubMed:27925655}; Multi-
CC pass membrane protein {ECO:0000255}. Note=Predominantly located in
CC endoplasmic reticulum membrane. {ECO:0000269|PubMed:27925655}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC Amino acid/auxin permease (AAAP) (TC 2.A.18.6) subfamily.
CC {ECO:0000305}.
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DR EMBL; AC018849; AAF27127.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE36414.1; -; Genomic_DNA.
DR EMBL; AF428472; AAL16241.1; -; mRNA.
DR EMBL; AY149936; AAN31090.1; -; mRNA.
DR PIR; A96837; A96837.
DR RefSeq; NP_565239.1; NM_106699.2.
DR AlphaFoldDB; Q9M8L9; -.
DR SMR; Q9M8L9; -.
DR IntAct; Q9M8L9; 1.
DR STRING; 3702.AT1G80510.1; -.
DR PaxDb; Q9M8L9; -.
DR PRIDE; Q9M8L9; -.
DR ProteomicsDB; 241161; -.
DR EnsemblPlants; AT1G80510.1; AT1G80510.1; AT1G80510.
DR GeneID; 844390; -.
DR Gramene; AT1G80510.1; AT1G80510.1; AT1G80510.
DR KEGG; ath:AT1G80510; -.
DR Araport; AT1G80510; -.
DR TAIR; locus:2198968; AT1G80510.
DR eggNOG; KOG1305; Eukaryota.
DR HOGENOM; CLU_034419_2_0_1; -.
DR InParanoid; Q9M8L9; -.
DR OMA; CHHNTSF; -.
DR OrthoDB; 697331at2759; -.
DR PhylomeDB; Q9M8L9; -.
DR PRO; PR:Q9M8L9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9M8L9; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005774; C:vacuolar membrane; IDA:UniProtKB.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Endoplasmic reticulum; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Vacuole.
FT CHAIN 1..489
FT /note="Amino acid transporter AVT6E"
FT /id="PRO_0000440116"
FT TRANSMEM 76..96
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..424
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..445
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
SQ SEQUENCE 489 AA; 52958 MW; 02BD16EFA1DA5DD2 CRC64;
MDSSYSVISK TSYVELQKPT VNGKPRNKLL PSDEESFVND FDDARNGVGG EDADDLDFDV
ADYPLVHGKS SNQGSGIYGA VFNLTTSIIG AGIMALPATM KVLGLVLGFV LIILMALLSE
ISVELLVRFS VLYKSKSYGE VVQFALGKTA RVLSEICIIV NNGGVLVVYL IIMGDVMSGS
LHHIGVLDQW LGNGFWDHRK VLILIVMVIF LAPLCALNKI DSLSVTSAAS VALAVVFVVV
CFVVATIKLI EGTIDPPRLS PDFGSKQAIL DLLVVIPIMS NAYVCHFNVQ PIYNELEGRS
PHKMNRVGRI TTAICVVVYA STAVSGYLLF GKDTESDILT NFDQDLGIRF SSAVNYIVRI
GYILHLVLVF PVIHFSLRET VNTLLFEGSP PLSESKKRSL GLTVVLLALI YIGSTMIPNI
WTAFKFTGAT SAVSLGFTFP ALIALRLGKQ SNSLSFVERS VSWLMLILAV VVSIVGTIGN
IYSLESKSD
