RRG8_YEAST
ID RRG8_YEAST Reviewed; 277 AA.
AC Q06109; D6W4B5;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Required for respiratory growth protein 8, mitochondrial;
GN Name=RRG8; OrderedLocusNames=YPR116W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP DISRUPTION PHENOTYPE.
RX PubMed=18657191; DOI=10.1111/j.1567-1364.2008.00418.x;
RA Herst P.M., Perrone G.G., Dawes I.W., Bircham P.W., Berridge M.V.;
RT "Plasma membrane electron transport in Saccharomyces cerevisiae depends on
RT the presence of mitochondrial respiratory subunits.";
RL FEMS Yeast Res. 8:897-905(2008).
RN [6]
RP FUNCTION.
RX PubMed=19751518; DOI=10.1186/gb-2009-10-9-r95;
RA Merz S., Westermann B.;
RT "Genome-wide deletion mutant analysis reveals genes required for
RT respiratory growth, mitochondrial genome maintenance and mitochondrial
RT protein synthesis in Saccharomyces cerevisiae.";
RL Genome Biol. 10:R95.1-R95.18(2009).
CC -!- FUNCTION: Required for respiratory activity and maintenance and
CC expression of the mitochondrial genome. {ECO:0000269|PubMed:19751518}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095}.
CC -!- DISRUPTION PHENOTYPE: Decrease in plasma membrane electron transport.
CC {ECO:0000269|PubMed:18657191}.
CC -!- MISCELLANEOUS: Present with 2140 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the RRG8 family. {ECO:0000305}.
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DR EMBL; U32445; AAB68086.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11531.1; -; Genomic_DNA.
DR PIR; S59781; S59781.
DR RefSeq; NP_015441.1; NM_001184213.1.
DR AlphaFoldDB; Q06109; -.
DR BioGRID; 36283; 16.
DR IntAct; Q06109; 2.
DR MINT; Q06109; -.
DR STRING; 4932.YPR116W; -.
DR MaxQB; Q06109; -.
DR PaxDb; Q06109; -.
DR PRIDE; Q06109; -.
DR EnsemblFungi; YPR116W_mRNA; YPR116W; YPR116W.
DR GeneID; 856232; -.
DR KEGG; sce:YPR116W; -.
DR SGD; S000006320; RRG8.
DR VEuPathDB; FungiDB:YPR116W; -.
DR eggNOG; ENOG502S46Y; Eukaryota.
DR HOGENOM; CLU_090059_0_0_1; -.
DR InParanoid; Q06109; -.
DR OMA; FHRWAGK; -.
DR BioCyc; YEAST:G3O-34255-MON; -.
DR PRO; PR:Q06109; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; Q06109; protein.
DR GO; GO:0099617; C:matrix side of mitochondrial inner membrane; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0000002; P:mitochondrial genome maintenance; IMP:SGD.
DR GO; GO:0097745; P:mitochondrial tRNA 5'-end processing; IMP:SGD.
DR InterPro; IPR031415; Rrg8.
DR Pfam; PF17068; RRG8; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome.
FT CHAIN 1..277
FT /note="Required for respiratory growth protein 8,
FT mitochondrial"
FT /id="PRO_0000242626"
SQ SEQUENCE 277 AA; 31133 MW; 429821FA1CA256C8 CRC64;
MGLPKSAYKK LLIDCPTRVI NKNCAQRVKD VSPLITNFEK WSDKRKKLYF KDEEEMVGQF
HLENFNLKNN LYGRLLASPM RAEKISKLKS CRELLIPLKV VPSTGKDQHA DKDKLKLVPT
LDYSKSYKSS YVLNSASIVQ DNLAAATSWF PISVLQTSTP KSLEVDSSTF ITEYNANLHA
FIKARLSVIP NVGPSSINRV LLICDKRKTP PIEIQVVSHG KGLPITQSVF NLGYLHEPTL
EAIVSKDAVT NGIYLDADND KDLIKHLYST LLFHSVN
