ID   AVT_CATCO               Reviewed;         434 AA.
AC   Q90352;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=[Arg8]-vasotocin receptor;
DE            Short=AVT;
OS   Catostomus commersonii (White sucker) (Cyprinus commersonnii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Catostomoidei; Catostomidae; Catostomus.
OX   NCBI_TaxID=7971;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=7509069; DOI=10.1073/pnas.91.4.1342;
RA   Mahlmann S., Meyerhof W., Hausmann H., Heierhorst J., Schoenrock C.,
RA   Zwiers H., Lederis K., Richter D.;
RT   "Structure, function, and phylogeny of [Arg8]vasotocin receptors from
RT   teleost fish and toad.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:1342-1345(1994).
CC   -!- FUNCTION: Binds to vasotocin. Produces an induction of membrane
CC       chloride currents indicating that it is coupled to the inositol
CC       phosphate/calcium pathway.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in pituitary, liver, gills, swim bladder
CC       and lateral line.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00521}.
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DR   EMBL; X76321; CAA53958.1; -; mRNA.
DR   PIR; I50132; I50132.
DR   AlphaFoldDB; Q90352; -.
DR   SMR; Q90352; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005000; F:vasopressin receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR015076; V1R_C.
DR   InterPro; IPR001817; Vasoprsn_rcpt.
DR   InterPro; IPR001224; Vprs_V1A_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   Pfam; PF08983; DUF1856; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00896; VASOPRESSINR.
DR   PRINTS; PR00752; VASOPRSNV1AR.
DR   SMART; SM01164; DUF1856; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..434
FT                   /note="[Arg8]-vasotocin receptor"
FT                   /id="PRO_0000069178"
FT   TOPO_DOM        1..27
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..67
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        89..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..141
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..191
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        213..257
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        279..295
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        317..434
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..176
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   434 AA;  49498 MW;  2C2A4A49EE1C2BA5 CRC64;
     MGRIANQTTA SNDTDPFGRN EEVAKMEITV LSVTFFVAVI GNLSVLLAMH NTKKKSSRMH
     LFIKHLSLAD MVVAFFQVLP QLCWEITFRF YGPDFLCRIV KHLQVLGMFA STYMMVMMTL
     DRYIAICHPL KTLQQPTQRA YIMIGSTWLC SLLLSTPQYF IFSLSEIQNG SYVYDCWGHF
     IEPWGIRAYI TWITVGIFLI PVIILMICYG FICHSIWKNI KCKTMRGTRN TKDGMIGKVS
     VSSVTIISRA KLRTVKMTLV IVLAYIVCWA PFFIVQMWSV WDENFSWDDS ENAAVTLSAL
     LASLNSCCNP WIYMLFSGHL LYDFLRCFPC CKKPRNMLQK EDSDSSIRRN TLLTKLAAGR
     MTNDGFGSWR DPCNSRKSSQ SIGLDCFCKS SQCLEHDCSR KSSQCIPLDC SRKSSQCIPL
     DCSRKSSQCM SKES