RRG_ARATH
ID RRG_ARATH Reviewed; 373 AA.
AC Q9C565; Q8LG43;
DT 17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein RETARDED ROOT GROWTH, mitochondrial {ECO:0000303|PubMed:21984726};
DE Flags: Precursor;
GN Name=RRG {ECO:0000303|PubMed:21984726};
GN OrderedLocusNames=At1g69380 {ECO:0000312|Araport:AT1G69380};
GN ORFNames=F10D13.7 {ECO:0000312|EMBL:AAG60106.1},
GN F23O10.4 {ECO:0000312|EMBL:AAG52494.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, MUTAGENESIS OF GLU-346, DISRUPTION PHENOTYPE, SUBCELLULAR
RP LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Columbia;
RX PubMed=21984726; DOI=10.1104/pp.111.185827;
RA Zhou X., Li Q., Chen X., Liu J., Zhang Q., Liu Y., Liu K., Xu J.;
RT "The Arabidopsis RETARDED ROOT GROWTH gene encodes a mitochondria-localized
RT protein that is required for cell division in the root meristem.";
RL Plant Physiol. 157:1793-1804(2011).
CC -!- FUNCTION: Required for the maintenance of mitochondrial structure
CC (PubMed:21984726). Positive regulator of cell division and
CC endoreduplication but negative regulator of cell expansion in the
CC postembryonic root meristem, thus leading to the promotion of root
CC growth (PubMed:21984726). {ECO:0000269|PubMed:21984726}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000305|PubMed:21984726}; Single-pass membrane protein
CC {ECO:0000255}. Mitochondrion {ECO:0000269|PubMed:21984726}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in the root meristem, in
CC the primary and lateral root tips (PubMed:21984726). Also present in
CC leaves and pollen (PubMed:21984726). {ECO:0000269|PubMed:21984726}.
CC -!- DEVELOPMENTAL STAGE: In root tips, preferentially expressed in
CC quiescent center (QC) cells, cortex/endodermis stem cells and their
CC daughter cells, and endodermal and stele cells of root meristems.
CC {ECO:0000269|PubMed:21984726}.
CC -!- DISRUPTION PHENOTYPE: Reduced number of dividing cells and slower rate
CC of cell production and endoreduplication, thus affecting root meristem
CC size and delaying postembryonic root growth (PubMed:21984726).
CC Decreased expression of several cell cycle genes indicating a defect in
CC cell cycle progression (PubMed:21984726). Extensive vacuolization in
CC mitochondria (PubMed:21984726). {ECO:0000269|PubMed:21984726}.
CC -!- SIMILARITY: Belongs to the RMD1/sif2 family. {ECO:0000305}.
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DR EMBL; AC018364; AAG52494.1; -; Genomic_DNA.
DR EMBL; AC073178; AAG60106.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34917.1; -; Genomic_DNA.
DR EMBL; AY084474; AAM61045.1; -; mRNA.
DR RefSeq; NP_564963.1; NM_105605.3.
DR AlphaFoldDB; Q9C565; -.
DR SMR; Q9C565; -.
DR STRING; 3702.AT1G69380.1; -.
DR PaxDb; Q9C565; -.
DR PRIDE; Q9C565; -.
DR ProteomicsDB; 185346; -.
DR EnsemblPlants; AT1G69380.1; AT1G69380.1; AT1G69380.
DR GeneID; 843270; -.
DR Gramene; AT1G69380.1; AT1G69380.1; AT1G69380.
DR KEGG; ath:AT1G69380; -.
DR Araport; AT1G69380; -.
DR TAIR; locus:2007161; AT1G69380.
DR eggNOG; KOG2861; Eukaryota.
DR HOGENOM; CLU_011220_2_2_1; -.
DR InParanoid; Q9C565; -.
DR OMA; HIMVLDK; -.
DR OrthoDB; 954411at2759; -.
DR PhylomeDB; Q9C565; -.
DR PRO; PR:Q9C565; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C565; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IDA:TAIR.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030308; P:negative regulation of cell growth; IMP:UniProtKB.
DR GO; GO:0051781; P:positive regulation of cell division; IMP:UniProtKB.
DR GO; GO:0010822; P:positive regulation of mitochondrion organization; IMP:UniProtKB.
DR GO; GO:0051302; P:regulation of cell division; IMP:TAIR.
DR GO; GO:0032875; P:regulation of DNA endoreduplication; IMP:TAIR.
DR GO; GO:0010082; P:regulation of root meristem growth; IMP:TAIR.
DR InterPro; IPR003734; DUF155.
DR Pfam; PF02582; DUF155; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Membrane; Mitochondrion; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix.
FT TRANSIT 1..49
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 50..373
FT /note="Protein RETARDED ROOT GROWTH, mitochondrial"
FT /id="PRO_0000450306"
FT TRANSMEM 346..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MUTAGEN 346
FT /note="E->K: In rrg-1; shorter root due to a reduced number
FT of dividing cells affecting postembryonic root meristem
FT size."
FT /evidence="ECO:0000269|PubMed:21984726"
FT CONFLICT 248
FT /note="D -> V (in Ref. 3; AAM61045)"
FT /evidence="ECO:0000305"
FT CONFLICT 360
FT /note="G -> S (in Ref. 3; AAM61045)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 373 AA; 42344 MW; 00020ECFBCE36F58 CRC64;
MGKWRAVAAL LLRNQLLNSS KRLNLSSSPC VSKHPTIGLA SRFLNFRHFS AFPSPISIYN
NDSDSGSNDA YQNYEFGTEA EEALGKIPIK AYFLSTSIDL KAMQAENLCN VVPPTSRSTN
YIALKFSDFT PSGIYSLDER ESVSNCKFMV VFQYGSAILF NVDDNDVDRY LDIVRRHASG
LLTEMRKDDY AVKEKPLLIE EMKGGPDYIV LKTLDTNSIR IIGSVLGQSI ALDYSVSQVN
KLVEEFADIN RSMAKTGTFT MTRKKLFQLV GKANSNIADV ILKVGLFERS EIAWREARYA
QIYEYLREEY EISQRFGDLD YKLKFIEHNI HFLQEVMQNR QSDLLEWCII FLLAIENAIG
IYEIVRESAG ASL
