RRL_ARATH
ID RRL_ARATH Reviewed; 402 AA.
AC Q9FNB2; Q8LCH7;
DT 17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Protein RETARDED ROOT GROWTH-LIKE {ECO:0000303|PubMed:26163700};
GN Name=RRL {ECO:0000303|PubMed:26163700};
GN OrderedLocusNames=At5g13610 {ECO:0000312|Araport:AT5G13610};
GN ORFNames=T6I14.13 {ECO:0000312|EMBL:BAB08687.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9405937; DOI=10.1093/dnares/4.4.291;
RA Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence
RT features of the regions of 1,044,062 bp covered by thirteen physically
RT assigned P1 clones.";
RL DNA Res. 4:291-300(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=26163700; DOI=10.1093/jxb/erv356;
RA Yao X., Li J., Liu J., Liu K.;
RT "An Arabidopsis mitochondria-localized RRL protein mediates abscisic acid
RT signal transduction through mitochondrial retrograde regulation involving
RT ABI4.";
RL J. Exp. Bot. 66:6431-6445(2015).
CC -!- FUNCTION: Mediates abscisic acid (ABA) signal transduction through
CC mitochondrial retrograde regulation involving ABI4 during seed
CC germination and seedling growth, and leading to the production of
CC reactive oxygen species (ROS) by the alternative respiratory pathway
CC (PubMed:26163700). Required for the maintenance of mitochondrial
CC structure (PubMed:26163700). {ECO:0000269|PubMed:26163700}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000305|PubMed:26163700}; Single-pass membrane protein
CC {ECO:0000255}. Mitochondrion {ECO:0000269|PubMed:26163700}.
CC -!- TISSUE SPECIFICITY: Highly expressed in germinating seeds and
CC developing seedlings (PubMed:26163700). Also present at low levels in
CC seedlings, roots, leaves, stems and flowers, and barely in siliques
CC (PubMed:26163700). {ECO:0000269|PubMed:26163700}.
CC -!- DISRUPTION PHENOTYPE: Decreased abscisic acid (ABA) sensitivity during
CC seed germination and seedling growth (PubMed:26163700). Abnormal
CC mitochondria extensively internally vacuolated and characterized by a
CC reduced ABA-stimulated reactive oxygen species (ROS) production
CC associated with the inhibition of ABA-induced AOX1a and ABI4 gene
CC expression (PubMed:26163700). {ECO:0000269|PubMed:26163700}.
CC -!- SIMILARITY: Belongs to the RMD1/sif2 family. {ECO:0000305}.
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DR EMBL; AB006704; BAB08687.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91917.1; -; Genomic_DNA.
DR EMBL; AY127015; AAM83240.1; -; mRNA.
DR EMBL; BT000617; AAN18184.1; -; mRNA.
DR EMBL; AY086593; AAM63653.1; -; mRNA.
DR RefSeq; NP_196865.1; NM_121364.3.
DR AlphaFoldDB; Q9FNB2; -.
DR SMR; Q9FNB2; -.
DR STRING; 3702.AT5G13610.1; -.
DR PaxDb; Q9FNB2; -.
DR PRIDE; Q9FNB2; -.
DR ProteomicsDB; 185330; -.
DR EnsemblPlants; AT5G13610.1; AT5G13610.1; AT5G13610.
DR GeneID; 831205; -.
DR Gramene; AT5G13610.1; AT5G13610.1; AT5G13610.
DR KEGG; ath:AT5G13610; -.
DR Araport; AT5G13610; -.
DR TAIR; locus:2173214; AT5G13610.
DR eggNOG; KOG2861; Eukaryota.
DR HOGENOM; CLU_011220_2_3_1; -.
DR InParanoid; Q9FNB2; -.
DR OMA; FHYGSIV; -.
DR OrthoDB; 954411at2759; -.
DR PhylomeDB; Q9FNB2; -.
DR PRO; PR:Q9FNB2; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FNB2; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IDA:TAIR.
DR GO; GO:0009738; P:abscisic acid-activated signaling pathway; IMP:TAIR.
DR GO; GO:0031930; P:mitochondria-nucleus signaling pathway; IMP:TAIR.
DR GO; GO:0007005; P:mitochondrion organization; IMP:TAIR.
DR InterPro; IPR003734; DUF155.
DR Pfam; PF02582; DUF155; 1.
PE 2: Evidence at transcript level;
KW Abscisic acid signaling pathway; Membrane; Mitochondrion;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..402
FT /note="Protein RETARDED ROOT GROWTH-LIKE"
FT /id="PRO_0000450307"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 166
FT /note="P -> L (in Ref. 4; AAM63653)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 402 AA; 46201 MW; 6C44FA3403A70498 CRC64;
MMRSVDVYVK TLGPPVRSIL YSIFTSQQKP SSLPSLPFHF SLRSSSNIPT RCFSNVVAKS
NSPIYDFQGF RNLFTERAIS SSTTTPVASA QPQQLQNQNQ HPAEVDEEIS MGLEDEAKLS
IPVRAYFFST SVDLRSLIEQ NKQNFIPPTS RMTNYVVLKF GNHSDPTDTT RGRISGSESI
YMVVFHYGSI VLFNVREHEV DEYLKVVERH ASGLLPEMRK DEYEVRENPN LDTWMEVGRD
FIRLQFLNTD GIRTIGCVLG QSIALDYYGR QVDGMVAEFT EINRQLEITG TFTMKRKKLF
QLVGKANVIL ADVILKLGLF ERSDIAWKDA KYGQIWEFLR DEFELTQSFA NLDYKLKFVE
HNVRFLQEIL QNRKSATLEW LIIILISMEI AISFYNMSRA SL
