ID   RRN10_SCHPO             Reviewed;          97 AA.
AC   Q10360;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=RNA polymerase I-specific transcription initiation factor rrn10;
GN   Name=rrn10; ORFNames=SPAC22E12.08;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION, IDENTIFICATION IN THE UAF COMPLEX, AND INTERACTION WITH RRN5 AND
RP   SPP27/UAF30.
RX   PubMed=12490702; DOI=10.1093/nar/gkf683;
RA   Liu M., Guo A., Boukhgalter B., Van Den Heuvel K., Tripp M., Pape L.;
RT   "Characterization of the fission yeast ribosomal DNA binding factor:
RT   components share homology with upstream activating factor and with SWI/SNF
RT   subunits.";
RL   Nucleic Acids Res. 30:5347-5359(2002).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Component of the UAF (upstream activation factor) complex
CC       which interacts with the upstream element of the RNA polymerase I
CC       promoter and forms a stable preinitiation complex. UAF seems to
CC       stimulate basal transcription to a fully activated level.
CC       {ECO:0000269|PubMed:12490702}.
CC   -!- SUBUNIT: Component of the UAF (upstream activation factor) complex
CC       which consists of spp27/uaf30, rrn5, rrn10, and histones H3 and H4.
CC       Interacts with rrn5 and spp27/uaf30. {ECO:0000269|PubMed:12490702}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus,
CC       nucleolus {ECO:0000269|PubMed:16823372}.
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DR   EMBL; CU329670; CAA93895.1; -; Genomic_DNA.
DR   PIR; T38165; T38165.
DR   RefSeq; NP_594834.1; NM_001020263.2.
DR   AlphaFoldDB; Q10360; -.
DR   BioGRID; 278326; 4.
DR   STRING; 4896.SPAC22E12.08.1; -.
DR   PaxDb; Q10360; -.
DR   EnsemblFungi; SPAC22E12.08.1; SPAC22E12.08.1:pep; SPAC22E12.08.
DR   GeneID; 2541835; -.
DR   KEGG; spo:SPAC22E12.08; -.
DR   PomBase; SPAC22E12.08; rrn10.
DR   VEuPathDB; FungiDB:SPAC22E12.08; -.
DR   HOGENOM; CLU_2347904_0_0_1; -.
DR   OMA; ATEYMLA; -.
DR   PRO; PR:Q10360; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0000500; C:RNA polymerase I upstream activating factor complex; EXP:PomBase.
DR   GO; GO:0001165; F:RNA polymerase I cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0042790; P:nucleolar large rRNA transcription by RNA polymerase I; IBA:GO_Central.
DR   GO; GO:0006361; P:transcription initiation from RNA polymerase I promoter; IMP:PomBase.
DR   InterPro; IPR022793; Rrn10.
DR   PANTHER; PTHR28054; PTHR28054; 1.
DR   Pfam; PF05234; UAF_Rrn10; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..97
FT                   /note="RNA polymerase I-specific transcription initiation
FT                   factor rrn10"
FT                   /id="PRO_0000116604"
SQ   SEQUENCE   97 AA;  11013 MW;  94BCAB1B8446A901 CRC64;
     MSNPPTRPTL YNLVNADGEL SYRARDLVQD FSVPIPHELP DPDLVHSIQD FATEYMLATG
     KKSFECLDES ALLGLGYLVT EWMDAMVTDC LEEFEER