RRN10_YEAST
ID RRN10_YEAST Reviewed; 145 AA.
AC P38204; D6VPX5;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=RNA polymerase I-specific transcription initiation factor RRN10;
GN Name=RRN10; OrderedLocusNames=YBL025W; ORFNames=YBL0426;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND IDENTIFICATION IN THE UAF COMPLEX.
RC STRAIN=NOY696;
RX PubMed=8846924; DOI=10.1101/gad.10.7.887;
RA Keys D.A., Lee B.-S., Dodd J.A., Nguyen T.T., Vu L., Fantino E.,
RA Burson L.M., Nogi Y., Nomura M.;
RT "Multiprotein transcription factor UAF interacts with the upstream element
RT of the yeast RNA polymerase I promoter and forms a stable preinitiation
RT complex.";
RL Genes Dev. 10:887-903(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7725803; DOI=10.1002/yea.320101217;
RA van Dyck L., Jonniaux J.-L., Barreiros T.D.M., Kleine K., Goffeau A.;
RT "Analysis of a 17.4 kb DNA segment of yeast chromosome II encompassing the
RT ribosomal protein L19 as well as proteins with homologies to components of
RT the hnRNP and snRNP complexes and to the human proliferation-associated
RT p120 antigen.";
RL Yeast 10:1663-1673(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [6]
RP FUNCTION OF THE UAF COMPLEX.
RX PubMed=9837969; DOI=10.1074/jbc.273.50.33795;
RA Keener J., Josaitis C.A., Dodd J.A., Nomura M.;
RT "Reconstitution of yeast RNA polymerase I transcription in vitro from
RT purified components. TATA-binding protein is not required for basal
RT transcription.";
RL J. Biol. Chem. 273:33795-33802(1998).
RN [7]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
CC -!- FUNCTION: Component of the UAF (upstream activation factor) complex
CC which interacts with the upstream element of the RNA polymerase I
CC promoter and forms a stable preinitiation complex. Together with
CC SPT15/TBP UAF seems to stimulate basal transcription to a fully
CC activated level. {ECO:0000269|PubMed:9837969}.
CC -!- SUBUNIT: Component of the UAF (upstream activation factor) complex
CC which consists of UAF30, RRN5, RRN9, RRN10, and histones H3 and H4.
CC {ECO:0000269|PubMed:8846924}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
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DR EMBL; U43682; AAC49259.1; -; Genomic_DNA.
DR EMBL; X77291; CAA54500.1; -; Genomic_DNA.
DR EMBL; Z35786; CAA84844.1; -; Genomic_DNA.
DR EMBL; AY558460; AAS56786.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07095.1; -; Genomic_DNA.
DR PIR; S45759; S45759.
DR RefSeq; NP_009528.1; NM_001178265.1.
DR AlphaFoldDB; P38204; -.
DR SMR; P38204; -.
DR BioGRID; 32673; 35.
DR ComplexPortal; CPX-1101; RNA polymerase I upstream activating factor complex.
DR DIP; DIP-1592N; -.
DR IntAct; P38204; 12.
DR MINT; P38204; -.
DR STRING; 4932.YBL025W; -.
DR MaxQB; P38204; -.
DR PaxDb; P38204; -.
DR PRIDE; P38204; -.
DR EnsemblFungi; YBL025W_mRNA; YBL025W; YBL025W.
DR GeneID; 852256; -.
DR KEGG; sce:YBL025W; -.
DR SGD; S000000121; RRN10.
DR VEuPathDB; FungiDB:YBL025W; -.
DR eggNOG; ENOG502S1BQ; Eukaryota.
DR HOGENOM; CLU_122953_0_0_1; -.
DR InParanoid; P38204; -.
DR OMA; HLINCFD; -.
DR BioCyc; YEAST:G3O-28928-MON; -.
DR PRO; PR:P38204; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P38204; protein.
DR GO; GO:0005730; C:nucleolus; IDA:SGD.
DR GO; GO:0005634; C:nucleus; IC:ComplexPortal.
DR GO; GO:0000500; C:RNA polymerase I upstream activating factor complex; IDA:SGD.
DR GO; GO:0001165; F:RNA polymerase I cis-regulatory region sequence-specific DNA binding; IDA:SGD.
DR GO; GO:0001181; F:RNA polymerase I general transcription initiation factor activity; IDA:SGD.
DR GO; GO:0042790; P:nucleolar large rRNA transcription by RNA polymerase I; IDA:SGD.
DR GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IDA:ComplexPortal.
DR InterPro; IPR022793; Rrn10.
DR InterPro; IPR007898; Rrn10_Saccharomycetes.
DR PANTHER; PTHR28054; PTHR28054; 1.
DR Pfam; PF05234; UAF_Rrn10; 1.
DR PIRSF; PIRSF009867; UAF_Rrn10; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..145
FT /note="RNA polymerase I-specific transcription initiation
FT factor RRN10"
FT /id="PRO_0000097445"
SQ SEQUENCE 145 AA; 16505 MW; 970E552D55ECE41D CRC64;
MDRNVYEACS NIIKEFGTHV VSADEVLAEK IDNAVPIPFK TREEIDADVE KDRNEGVFEG
NIIPDIDLRV VHYYATQLCL NKYPHLINAF DETSLITLGL LIEKWVKDYL TSIQTEQGRQ
SKVIGKGPCE FISKHIDYRH APGNI
