ID   RRN3_PONAB              Reviewed;         650 AA.
AC   Q5R4N9;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=RNA polymerase I-specific transcription initiation factor RRN3;
GN   Name=RRN3;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for efficient transcription initiation by RNA
CC       polymerase I. Required for the formation of the competent preinitiation
CC       complex (PIC). Dissociates from pol I as a consequence of
CC       transcription. In vitro, cannot activate transcription in a subsequent
CC       transcription reaction (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with POLR1F, EIF3L, TAF1B and TAF1C. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- PTM: Phosphorylated at Thr-199 by MAPK9/JNK2, which abrogates
CC       initiation complex formation. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRN3 family. {ECO:0000305}.
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DR   EMBL; CR861206; CAH93277.1; -; mRNA.
DR   RefSeq; NP_001126928.1; NM_001133456.1.
DR   AlphaFoldDB; Q5R4N9; -.
DR   SMR; Q5R4N9; -.
DR   STRING; 9601.ENSPPYP00000008688; -.
DR   GeneID; 100173945; -.
DR   KEGG; pon:100173945; -.
DR   CTD; 54700; -.
DR   eggNOG; KOG2434; Eukaryota.
DR   InParanoid; Q5R4N9; -.
DR   OrthoDB; 855834at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001181; F:RNA polymerase I general transcription initiation factor activity; IEA:InterPro.
DR   GO; GO:0006361; P:transcription initiation from RNA polymerase I promoter; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR007991; RNA_pol_I_trans_ini_fac_RRN3.
DR   PANTHER; PTHR12790; PTHR12790; 1.
DR   Pfam; PF05327; RRN3; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..650
FT                   /note="RNA polymerase I-specific transcription initiation
FT                   factor RRN3"
FT                   /id="PRO_0000211427"
FT   REGION          499..650
FT                   /note="Interaction with POLR1F"
FT                   /evidence="ECO:0000250"
FT   REGION          556..650
FT                   /note="Interaction with EIF3L"
FT                   /evidence="ECO:0000250"
FT   REGION          630..650
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         169
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NYV6"
FT   MOD_RES         171
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NYV6"
FT   MOD_RES         199
FT                   /note="Phosphothreonine; by MAPK9"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NYV6"
FT   MOD_RES         639
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NYV6"
SQ   SEQUENCE   650 AA;  73935 MW;  3FAB8EC7757AABA0 CRC64;
     MAAPLLHTRL PGDAAASSSA VKTLGASRTG ISNMRALEND FFSSPPRKTV RFGGTVTEVL
     LKYKKGETND FELLKNQLLD PDIKDDQIIS WLLEFRSSVM YLTKDFEQLI SIILRLPWLK
     SQTVVEEYLA FLANLVSAQT VFLRPCLGMI ASHFVPPRVI IKEGDVDVSD SDDEDDNLPA
     NFDTCHRALQ IIARYVPSTP WFLMPILVEK FPFVRKSERT LECYVHNLLR ISVYFPTLRH
     EILELIIEKL LKLDVNASRQ DIEDAEETAT QTCGGTDSTE GLFNMDEDEE TEHETKAGPE
     RLDQMVHPVA ECLDILMSLV LSYMKDVCYV DGQVDNGKTK DLYRDLINIF DKLLLSTHAS
     CHVQFFMFYL CSFKLGFAEA FLEHLWKKLQ DPSNPAIIRQ AAGNYIGSFL ARAKFIPLIT
     VRSCLDLLVN WLHIYLNNQD SGTKAFCDVA LHGPFYSACQ AVFYTFVFRH KQLLSGNLKE
     GLRYLQSLNF EWIVMSQLNP LKICLPSVVN FFAAITNKYQ LVFCYTIIER NNRQMLPVIR
     STAGGDSVQT CTNPLDTFFP FDPCVLKRSK KFIDPIYQVW EDMSAEELQE FKKPMRKEIV
     EDEDDDFLKG EVPQNDTVIG ITPSSFDAHF RSPSSSVGSP PVLYMQPSPL