RRP12_DROME
ID RRP12_DROME Reviewed; 1384 AA.
AC Q9VYA7; Q960Z7;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=RRP12-like protein;
GN ORFNames=CG2691;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 359-1384.
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=17372656; DOI=10.1039/b617545g;
RA Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA Eng J.K., Aebersold R., Tao W.A.;
RT "An integrated chemical, mass spectrometric and computational strategy for
RT (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT Kc167 cells.";
RL Mol. Biosyst. 3:275-286(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82; SER-85; SER-96; SER-1094;
RP SER-1095; SER-1117; SER-1119; SER-1221; SER-1225; SER-1227; SER-1230;
RP SER-1250 AND SER-1251, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RRP12 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK93177.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE014298; AAF48296.2; -; Genomic_DNA.
DR EMBL; AY051753; AAK93177.1; ALT_INIT; mRNA.
DR RefSeq; NP_001285218.1; NM_001298289.1.
DR RefSeq; NP_572906.2; NM_132678.3.
DR AlphaFoldDB; Q9VYA7; -.
DR BioGRID; 58697; 16.
DR IntAct; Q9VYA7; 4.
DR STRING; 7227.FBpp0073679; -.
DR iPTMnet; Q9VYA7; -.
DR PaxDb; Q9VYA7; -.
DR DNASU; 32320; -.
DR EnsemblMetazoa; FBtr0073848; FBpp0073679; FBgn0030504.
DR EnsemblMetazoa; FBtr0340191; FBpp0309168; FBgn0030504.
DR GeneID; 32320; -.
DR KEGG; dme:Dmel_CG2691; -.
DR UCSC; CG2691-RA; d. melanogaster.
DR FlyBase; FBgn0030504; CG2691.
DR VEuPathDB; VectorBase:FBgn0030504; -.
DR eggNOG; KOG1248; Eukaryota.
DR HOGENOM; CLU_003753_0_1_1; -.
DR InParanoid; Q9VYA7; -.
DR OMA; VLVRTNC; -.
DR OrthoDB; 833555at2759; -.
DR PhylomeDB; Q9VYA7; -.
DR BioGRID-ORCS; 32320; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 32320; -.
DR PRO; PR:Q9VYA7; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030504; Expressed in egg cell and 24 other tissues.
DR ExpressionAtlas; Q9VYA7; baseline and differential.
DR Genevisible; Q9VYA7; DM.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012978; Uncharacterised_NUC173.
DR Pfam; PF08161; NUC173; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..1384
FT /note="RRP12-like protein"
FT /id="PRO_0000372662"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1082..1102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1114..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1176..1384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1176..1193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1241..1273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1298..1318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 82
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656,
FT ECO:0000269|PubMed:18327897"
FT MOD_RES 85
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 96
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1094
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1095
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1117
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1119
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1221
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1225
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1227
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1230
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1250
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1251
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 1384 AA; 153557 MW; 8D2AA4A4E06BD0F8 CRC64;
MGKFRSKLKR NGKGKTWSRG ESATSNPTQM KHRMKAKSRF FQPNLSLAAA TTTGLTMEAV
HKHEQSQAFN AETTTVNDVA GSLRSFKLDD DDDGMSGSGT APTGTAPTGT IKTFQTFASN
YSGCSNTCFQ KLVTSFRSSS ALHKEMLAIL SALTEIIREN GGGESSTEYF LLLMEQIEAA
TEERDIVAGV TLLAMGINSV PAPVLKKRFA QTADTMQRLL QRFMESTNQS VIRHVIGCLS
VILRAQDYAA WSYSSTFQYF DAILAFSIHS QPKIRKAAQH AIALIIHGSC FMLPAIKSDD
NEMDEAVEQP KVKHHPASSR VAKFCLAQFK PEVLANAQTT VLHTLELLKD TLYGFKTEDI
RSVCEHLLSI MTAANVLVRT NCFQTLYSLF LKKSPNLNAS LCAKLLAAIH EYRPDKSDIR
QTIAWVTVLK EGHLHLATMQ LDLCMQALPR LIDVCTTDLW LSDQKELVAG VSNCIKELLQ
DCVSRACATA EDAQCNRQSV SRIIASLHKM LNAPFGEISR FVILIFSFVF EACGKLFGSE
LTPPLMTICK RYDTQSAHRL QIEHTVISAI KALGPELVLT AIPLADGKGV MQLERSWLLP
LLREGANGAS LQFFKEKIVA LAMDCQLKWK EFAEAKNNSS SHIYELLCCQ LWGLFPGFCR
QPRDPEYLRY LAPTLGAAVE KNPEFRPPIY DGLMELLGDN QSAECHQAIG QYAKNFLPRL
FNIYTQKPNG TYEADQRKRV LEVIRLYISR APADVQLELF ENAQEQLAAS ALASFEYDAF
FDINAAIVRV QTCKGIKAYF DKYMAPILRN DKSKLVAKDE QKLKKQQRKT YELLRELMTS
ELPSCQKFTR KNSIVLQQIL LDSFNTSCNV CQASRLHCLK SLIDCHSNLA YNDQLVMKAI
PEAVLNYKEF SNYKEQVAEQ LIKSITQLYH DAGKINDFVD ILTAGFAGDE MLVTNTILAF
RAVLQQQGEH LTVATLEFVL QQVSVFLVQK SRKQAEAAIA FLITFIKVMP IPLVANHLEA
IMRSLSAMTK DTKRYCRIQI GYLLKKLCIR FSPGELAGFV PGDDDVIHRR LKMIRKRTRR
DLRKKQNLEA QEDSSDDELV SGLQEKSYTI DDMLADSDSD LPEDMDAKDE AGAAAAASKR
SKNAKQQKST YIREDPDEIV DLADLKSIGN VLTSGSAQTA TPAQSQKTKA QLPNGGFKTA
DDGRLIISDK ALRGQGGNDQ SDDDSDSDAS MAYGTVAKQP KVKRGMEDDS SDEDKLQQKL
VPKRVRKGDD AMSMKSGKTT ASSRYTAGGK GIHRQLTAGN SDAMSVKSGK STSRPAGSEY
GSKKAKGDMK KSGKLDPYAY IPLTRNNLNK RKRSMNSRKF KSVLRGAGAE NGGAGGGRVS
KKYK
