RRP12_MOUSE
ID RRP12_MOUSE Reviewed; 1295 AA.
AC Q6P5B0; Q7TMI5; Q80TU2;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=RRP12-like protein;
GN Name=Rrp12; Synonyms=Kiaa0690;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Mesenchymal stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1081, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1081, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1081, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Nucleus
CC membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RRP12 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC65628.3; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK122346; BAC65628.3; ALT_SEQ; mRNA.
DR EMBL; BC056232; AAH56232.1; -; mRNA.
DR EMBL; BC062977; AAH62977.1; -; mRNA.
DR CCDS; CCDS29814.1; -.
DR RefSeq; NP_955518.1; NM_199447.2.
DR AlphaFoldDB; Q6P5B0; -.
DR BioGRID; 223201; 21.
DR IntAct; Q6P5B0; 1.
DR STRING; 10090.ENSMUSP00000039853; -.
DR iPTMnet; Q6P5B0; -.
DR PhosphoSitePlus; Q6P5B0; -.
DR SwissPalm; Q6P5B0; -.
DR EPD; Q6P5B0; -.
DR jPOST; Q6P5B0; -.
DR MaxQB; Q6P5B0; -.
DR PaxDb; Q6P5B0; -.
DR PRIDE; Q6P5B0; -.
DR ProteomicsDB; 260848; -.
DR Antibodypedia; 30844; 63 antibodies from 18 providers.
DR DNASU; 107094; -.
DR Ensembl; ENSMUST00000038677; ENSMUSP00000039853; ENSMUSG00000035049.
DR GeneID; 107094; -.
DR KEGG; mmu:107094; -.
DR UCSC; uc008hmk.1; mouse.
DR CTD; 23223; -.
DR MGI; MGI:2147437; Rrp12.
DR VEuPathDB; HostDB:ENSMUSG00000035049; -.
DR eggNOG; KOG1248; Eukaryota.
DR GeneTree; ENSGT00390000013106; -.
DR HOGENOM; CLU_003753_0_0_1; -.
DR InParanoid; Q6P5B0; -.
DR OMA; VLVRTNC; -.
DR OrthoDB; 833555at2759; -.
DR PhylomeDB; Q6P5B0; -.
DR TreeFam; TF300780; -.
DR BioGRID-ORCS; 107094; 27 hits in 75 CRISPR screens.
DR ChiTaRS; Rrp12; mouse.
DR PRO; PR:Q6P5B0; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q6P5B0; protein.
DR Bgee; ENSMUSG00000035049; Expressed in otic placode and 226 other tissues.
DR ExpressionAtlas; Q6P5B0; baseline and differential.
DR Genevisible; Q6P5B0; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012978; Uncharacterised_NUC173.
DR Pfam; PF08161; NUC173; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Isopeptide bond; Membrane; Nucleus; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix; Ubl conjugation.
FT CHAIN 1..1295
FT /note="RRP12-like protein"
FT /id="PRO_0000050769"
FT TRANSMEM 904..924
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1273..1295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1054..1069
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1181..1206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5JTH9"
FT MOD_RES 72
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5JTH9"
FT MOD_RES 77
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q5JTH9"
FT MOD_RES 88
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q5JTH9"
FT MOD_RES 97
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5JTH9"
FT MOD_RES 1050
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5JTH9"
FT MOD_RES 1073
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5JTH9"
FT MOD_RES 1081
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"
FT CROSSLNK 71
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO1)"
FT /evidence="ECO:0000250|UniProtKB:Q5JTH9"
FT CONFLICT 706
FT /note="E -> G (in Ref. 2; AAH56232)"
FT /evidence="ECO:0000305"
FT CONFLICT 732
FT /note="S -> G (in Ref. 1; BAC65628 and 2; AAH56232)"
FT /evidence="ECO:0000305"
FT CONFLICT 1050
FT /note="S -> N (in Ref. 2; AAH56232)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1295 AA; 143131 MW; E662BD4432B43C50 CRC64;
MGRSGKLPSG VSAKLKRWKK GHSSDSNPAT CRHRQAARSR FFSRPSGKSD LTVDAVKLHN
ELQSGTLSLG KSQAPETTMD QDPEVAFTEK SSGTFLSGLS DCTNVTFSKV QRFWESNSAA
HKEICAVLAA VTEVIRSQGG KETETEYFAA LMTTMEAVES PESLAAVAYL LNLVLKRVPS
PVLMKKFSDT SKAFMDIMSA QASSGSTSAL RWVLSCLAIL LRKQDLEAWG YPITLQVYHG
LLSFTVHAKP KIRKAAQHGV CSVLKGSDFM FGEKAPAHHP AAVSTAKFCI QEIEKSGGSK
EATTTLHMLT LLKDMLPCFP EGLVKSCSET LLRVMTLNHV LVTACAMQAF HNLFHAKPSP
STLSAELNAQ IVTALYDYVP SENDLQPLLA WLKVMEKAHI NLVRLQRDLG LGHLARFFGT
AVTCLLSPHS QVAAAATQTL KEILKECVAP HIADIGSVTS SASGPPQYIT KMFRAVEEGL
TYKFHAAWSS VLQLLGVFFE ACGKQAHPVM KKCLQSLCDL RLSPHFPHTA ALDQAVGAAV
TSMGPEVVLQ AVPLEIDGSE ETLDFPRSWL LPVIRDHVRE TRLGFFTTYF LPLATTLKRK
AMDLAQAGST VESKIYDTLQ WQIWTLLPGF CTRPTDVAAS FKGLARTLGT AINERPDLRV
TVCQALRTLI TKGCEAEADR AEVSRFAKNF LPILFNLYGQ PVAAGEAAAP RRAVLETIKT
YLTITEAQLV NSFLEKATEK VLDPASSDFT RLSVLDLVVA LAPYSDEAAI SKLYSTIRPY
LESKVHGVQK KAYRVLEEVC ASSQGPAARF VQSHLDDLKK TLLDSLRTTS SPAKRPRLKC
LIHIVKTLSA EHEEFIAALI PEVILCTKEV SVGARKSAFT LLVEMGHAFL RFGSNQEDAL
QRYLVLIYPG LLGAVTTVSC SILALTHLLF EFKGLMGTST VEQLLENVCL LLASRTRDVV
KSALGFIKVA VVVMDVVHLA KHVQLVMEAI GKLSDDMRRH FRMKLRNLFI KFTRKFGFEL
VKGLLPAEYH KVLINIRKAE TRAKKHRALS QAAVEEEEEE EEEEEPVQSK GDSIEEILAD
SEDEDEEEER GRGKEQRKLA RQRSRAWLKE GGGDEPLNFL DPKVAHRVLA TQPGPGRGKK
RDHGFKLSAD GRLIIREEED GNKVEEEDGT KGEDEDMTDA MEDASVRSKK KLKRQREDEE
DELEIPPRYQ AGGSGIHRPV AKKAAPGAEY KAKKAKGDVK KKGRLDPYAY VPLNRSKLNR
RKKVKLQGQF KGLVKATQRG SQAGHKLRRK DRRRP
