ID   RRP12_SCHPO             Reviewed;        1163 AA.
AC   Q9C0X8;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Putative ribosomal RNA-processing protein 12;
GN   Name=rrp12; ORFNames=SPAPB8E5.07c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1] {ECO:0000312|EMBL:CAC37426.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Required for nuclear export of the ribosomal subunits.
CC       Required for maturation of the RNA components of pre-ribosomes (By
CC       similarity). {ECO:0000250|UniProtKB:Q12754}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, spindle pole body
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the RRP12 family.
CC       {ECO:0000250|UniProtKB:Q12754}.
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DR   EMBL; CU329670; CAC37426.1; -; Genomic_DNA.
DR   RefSeq; NP_594781.1; NM_001020209.2.
DR   AlphaFoldDB; Q9C0X8; -.
DR   STRING; 4896.SPAPB8E5.07c.1; -.
DR   iPTMnet; Q9C0X8; -.
DR   MaxQB; Q9C0X8; -.
DR   PaxDb; Q9C0X8; -.
DR   PRIDE; Q9C0X8; -.
DR   EnsemblFungi; SPAPB8E5.07c.1; SPAPB8E5.07c.1:pep; SPAPB8E5.07c.
DR   GeneID; 2543238; -.
DR   KEGG; spo:SPAPB8E5.07c; -.
DR   PomBase; SPAPB8E5.07c; rrp12.
DR   VEuPathDB; FungiDB:SPAPB8E5.07c; -.
DR   eggNOG; KOG1248; Eukaryota.
DR   HOGENOM; CLU_003753_1_0_1; -.
DR   InParanoid; Q9C0X8; -.
DR   OMA; RKCSEDI; -.
DR   PhylomeDB; Q9C0X8; -.
DR   PRO; PR:Q9C0X8; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR   GO; GO:0030490; P:maturation of SSU-rRNA; ISO:PomBase.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012978; Uncharacterised_NUC173.
DR   Pfam; PF08161; NUC173; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..1163
FT                   /note="Putative ribosomal RNA-processing protein 12"
FT                   /id="PRO_0000273518"
FT   REGION          1127..1163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1140..1163
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1163 AA;  130530 MW;  64730FB126F1255F CRC64;
     MAEVNEPLQI ELRKIRNSST AGVINEFDVI VSAVEGTLKE QKTEATPTAY LVALLTLVKE
     FTDLKKNFKG HTFQLLELVI KYVPSNVLQA KFPQILSVLA PVVNNAETNK TVLLPYLNVL
     EKLLLLQDYS SWTHGNSCKT SIYILLFFAL SNTEKTRVRS LQILANILKN PPAGPVTEHP
     AIKYTAFEPL RLLESLATAK KPKTPAEVQK LNNSLVLIRV LCSSTHWPMT LVERLCRSCV
     LIVGQRSTNS ILLVYQILDG LSKKSVDYTD AVSLRMTLIC LQKLEPSEHD PILMVGWLKA
     MNTAIRAFNI LDKETAKYEC LHRFKAFFTL LESESMEIRL QTATTICSVI GCLDTTPNSF
     AVVEEICSFI CDALRDIRFR LAYPECFQII SSLCDKLGPH SDPYLIPALE VIDYLRGSEG
     FDGKALVDEA IGSFVRAIGP EAMLRVLPLN LELNDKDAVG RAWLLPVLRD NIRFANLAHF
     TNYFVPLSGQ LYQKVIEMND LDSIPSKLLQ TLVDQIWSLL PGYCYLPLDL QSSFTLEFAS
     ILVNVLYEQV SLRSVICNSL TALVETNSKV ADKLPLDDVI SVPVSASDAS SNLAFLTNMS
     SNFLSVLLNV FSSTPSQYRY PILKCIQTWI FISSNDTIHS VYKKVTDLLP DSLNDLAGSF
     NIAADGISSP MAYSLIDLLI VISPYLNQDY AVTLFEYVHE FLRHVNPAIQ KKGYKLLGTL
     LRVDYGKAYA TQHVKEIFEE LSSVADRVVS STRKDRLASL NALYELQSSE LVIAIPQLLP
     EAIISLKEVN EKARHTAFQL LFNIAKSAVN SVEFGNSKPE RVEKFVSVIS AGLAGSSTHM
     ISATIIAISS IVMEYKVFIS EPFLVQLIST LNLFITSSKR EIAKAAIDFI KISVSSFPVE
     CIKPLLPELI PNLLAWSHEG KANLRVKVRH LFEKMGRKYG IAEIEPFFPA EDKKLITNIR
     KTQERNIRKR AMKRDPAKPS SAQPRKTFAS AYEAAVYDTD DEAEEEFEND EMNNGNGGDL
     RMDEAFVQED NDEEPLDLLD IEAVSKISST DPRKKLAARK QKLNSAFKSN EEGRLLINDS
     DEDELIEDSL ANAQQHAEVN RTYLEAVAGK ESFRRGLNNR VKFSNKRVRD DYDEEMEEVE
     VPEVTRKPAK QKFDRKQRGQ KGY