RRP1L_DROME
ID RRP1L_DROME Reviewed; 687 AA.
AC Q9VJZ7; Q6AWH7;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Ribosomal RNA processing protein 1 homolog;
DE AltName: Full=NNP-1 homolog;
DE AltName: Full=RRP1-like protein;
GN Name=Nnp-1; ORFNames=CG12396;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-617; THR-620 AND SER-622, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: May be involved in the generation of 28S rRNA. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the RRP1 family. {ECO:0000305}.
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DR EMBL; AE014134; AAF53287.1; -; Genomic_DNA.
DR EMBL; BT015271; AAT94500.1; -; mRNA.
DR RefSeq; NP_651976.1; NM_143719.3.
DR AlphaFoldDB; Q9VJZ7; -.
DR SMR; Q9VJZ7; -.
DR BioGRID; 69025; 10.
DR DIP; DIP-20610N; -.
DR IntAct; Q9VJZ7; 3.
DR STRING; 7227.FBpp0080052; -.
DR iPTMnet; Q9VJZ7; -.
DR PaxDb; Q9VJZ7; -.
DR PRIDE; Q9VJZ7; -.
DR DNASU; 44391; -.
DR EnsemblMetazoa; FBtr0080473; FBpp0080052; FBgn0022069.
DR GeneID; 44391; -.
DR KEGG; dme:Dmel_CG12396; -.
DR UCSC; CG12396-RA; d. melanogaster.
DR CTD; 44391; -.
DR FlyBase; FBgn0022069; Nnp-1.
DR VEuPathDB; VectorBase:FBgn0022069; -.
DR eggNOG; KOG3911; Eukaryota.
DR GeneTree; ENSGT00390000011821; -.
DR HOGENOM; CLU_021225_0_0_1; -.
DR InParanoid; Q9VJZ7; -.
DR OMA; KLVAQCR; -.
DR OrthoDB; 1337189at2759; -.
DR PhylomeDB; Q9VJZ7; -.
DR SignaLink; Q9VJZ7; -.
DR BioGRID-ORCS; 44391; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Nnp-1; fly.
DR GenomeRNAi; 44391; -.
DR PRO; PR:Q9VJZ7; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0022069; Expressed in wing disc and 23 other tissues.
DR Genevisible; Q9VJZ7; DM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0030688; C:preribosome, small subunit precursor; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR InterPro; IPR010301; RRP1-like.
DR PANTHER; PTHR13026; PTHR13026; 1.
DR Pfam; PF05997; Nop52; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome; rRNA processing.
FT CHAIN 1..687
FT /note="Ribosomal RNA processing protein 1 homolog"
FT /id="PRO_0000096886"
FT REGION 288..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..547
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 617
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 620
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 622
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 687 AA; 78996 MW; 8055B70217B78604 CRC64;
MVTRKKPVKR NAEAAEIQVE QEEDASQPKV AKELMVVAQE VKIIRALACN DVVERNRQIR
ILRKWFKARA GSSFPFNEDD FMRIWKGLYY TMWMSDKPLV QEELAEKLAQ MVDSFGGNTA
CSLAYFSAFM RTMCQEYFGI DQWRMDKFLM LTRRMVRYLL RFLKQNNWNA DLIAAFNSSM
QLSVMSEQPK SRGMTMHYLD VFFEELAKAA NGEITAAQVN MFLRPFVTYI ATQRDAKLVA
QCRTRVLYHL MYQSDLGRQY SEKYNAWKQM GFPTASIDDI EKLDSGFDEE DDEVNAEEEQ
PRATSLDPRA GNVDVHMPEL PLNADCVLDE LQTQLRTNDF NSKRRKGLRK LIQIFETYQR
GEFPLGVRTM PKVEGQTLSE MVEQKVAALD KMEDEVFATG RKLKKLNKSK RKRLLQSINF
EEVDEHNYDE VISKALPPEL QKKVNYNAKV RSSINNAWVV EEVKEAEPKS KKAKKEEPPQ
QNKDDQTKVK KKSQLKPKND QSKPKIEDQP TLKAEKEEPA KRKKLDHSKT KEEQSKPKTD
EQPKPTPKVE GQSKAKPTPK TKAAGVDDDA PTNGWDAPLE DGEQDIFVPS RKLQVKQANS
KLPQSTPKQP ARAEFATPQT GSGKHVRIVT KSNCIYPKSD YYRQLKLSPQ VPYDANRLPG
KSALKPHWIP GPIHPSYKAK RLFNDTL
