RRP1_MOUSE
ID RRP1_MOUSE Reviewed; 494 AA.
AC P56183; O35712; Q9ERE1; Q9JI07; Q9JK67; Q9JKU2;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 06-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Ribosomal RNA processing protein 1 homolog A;
DE AltName: Full=Novel nuclear protein 1;
DE Short=NNP-1;
DE AltName: Full=Nucleolar protein Nop52;
DE AltName: Full=RRP1-like protein;
GN Name=Rrp1; Synonyms=Nnp1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND DEVELOPMENTAL STAGE.
RC TISSUE=Pituitary;
RX PubMed=9192856; DOI=10.1006/geno.1997.4755;
RA Jansen E., Meulemans S.M.P., Orlans I.C.R., Van de Ven W.J.M.;
RT "The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in
RT close proximity to the cystatin B gene within the EPM1 and APECED critical
RT region on 21q22.3.";
RL Genomics 42:336-341(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND ALTERNATIVE SPLICING.
RC STRAIN=129/Ola; TISSUE=Spleen;
RA Tsyba L., Skripkina I., Anoprienko O., Kvasha S., Slavov D., Tassone F.,
RA Rynditch A., Gardiner K.;
RT "Mouse homologues of human chromosome 21 genes.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Plays a critical role in the generation of 28S rRNA.
CC {ECO:0000250|UniProtKB:P56182}.
CC -!- SUBUNIT: Interacts with C1QBP. Interacts with RRP1B.
CC {ECO:0000250|UniProtKB:P56182}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:P56182}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=P56183-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P56183-2; Sequence=VSP_004335, VSP_004336;
CC Name=3;
CC IsoId=P56183-3; Sequence=VSP_004337;
CC -!- DEVELOPMENTAL STAGE: Embryonic, expression starting between days 1 and
CC 10. {ECO:0000269|PubMed:9192856}.
CC -!- SIMILARITY: Belongs to the RRP1 family. {ECO:0000305}.
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DR EMBL; U79773; AAC53286.1; -; mRNA.
DR EMBL; U79774; AAB63261.1; -; mRNA.
DR EMBL; AF294729; AAF76216.2; -; Genomic_DNA.
DR EMBL; AF312394; AAG30293.1; -; mRNA.
DR EMBL; BC065993; AAH65993.1; -; mRNA.
DR EMBL; BC065994; AAH65994.1; -; mRNA.
DR CCDS; CCDS35961.1; -. [P56183-1]
DR RefSeq; NP_035055.2; NM_010925.2. [P56183-1]
DR AlphaFoldDB; P56183; -.
DR SMR; P56183; -.
DR BioGRID; 201798; 24.
DR CORUM; P56183; -.
DR STRING; 10090.ENSMUSP00000058785; -.
DR iPTMnet; P56183; -.
DR PhosphoSitePlus; P56183; -.
DR EPD; P56183; -.
DR jPOST; P56183; -.
DR MaxQB; P56183; -.
DR PaxDb; P56183; -.
DR PeptideAtlas; P56183; -.
DR PRIDE; P56183; -.
DR ProteomicsDB; 260849; -. [P56183-1]
DR ProteomicsDB; 260850; -. [P56183-2]
DR ProteomicsDB; 260851; -. [P56183-3]
DR Antibodypedia; 5231; 169 antibodies from 25 providers.
DR DNASU; 18114; -.
DR Ensembl; ENSMUST00000062678; ENSMUSP00000058785; ENSMUSG00000061032. [P56183-1]
DR GeneID; 18114; -.
DR KEGG; mmu:18114; -.
DR UCSC; uc007fxs.1; mouse. [P56183-1]
DR CTD; 8568; -.
DR MGI; MGI:1203500; Rrp1.
DR VEuPathDB; HostDB:ENSMUSG00000061032; -.
DR eggNOG; KOG3911; Eukaryota.
DR GeneTree; ENSGT00390000011821; -.
DR HOGENOM; CLU_022876_2_0_1; -.
DR InParanoid; P56183; -.
DR OMA; QTMIREW; -.
DR OrthoDB; 1337189at2759; -.
DR PhylomeDB; P56183; -.
DR TreeFam; TF315294; -.
DR BioGRID-ORCS; 18114; 29 hits in 75 CRISPR screens.
DR ChiTaRS; Rrp1; mouse.
DR PRO; PR:P56183; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; P56183; protein.
DR Bgee; ENSMUSG00000061032; Expressed in dentate gyrus of hippocampal formation granule cell and 269 other tissues.
DR ExpressionAtlas; P56183; baseline and differential.
DR Genevisible; P56183; MM.
DR GO; GO:0005694; C:chromosome; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0030688; C:preribosome, small subunit precursor; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR InterPro; IPR010301; RRP1-like.
DR PANTHER; PTHR13026; PTHR13026; 1.
DR Pfam; PF05997; Nop52; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Phosphoprotein; Reference proteome;
KW rRNA processing.
FT CHAIN 1..494
FT /note="Ribosomal RNA processing protein 1 homolog A"
FT /id="PRO_0000096888"
FT REGION 239..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..300
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..424
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..464
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 254
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P56182"
FT MOD_RES 434
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 455
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P56182"
FT VAR_SEQ 245..258
FT /note="ASDGDDGEASDGDD -> GSDEDDGDDDSDEA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9192856"
FT /id="VSP_004335"
FT VAR_SEQ 259..309
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9192856"
FT /id="VSP_004336"
FT VAR_SEQ 450..484
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_004337"
FT CONFLICT 50
FT /note="D -> C (in Ref. 2; AAG30293)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 494 AA; 54777 MW; 9866F1BD7AE3E99D CRC64;
MVPGVPLPPE IQLAQRLAGN EQVTRDRALR KLRKYIEARS QRATGGFTPD ELLKVWKGLF
YCMWMQDKPL QQEELGRTIA QLVHAFHTTE AQHQFLKAFW QTMIREWVGI DRLRLDKFYM
LMRMVLSESL KAVKARGWDE RQIEQLLELL TTEILNPDSQ APSGVKSHFL EIFLEELAKV
GAAELTADQN LQFIDPFCQI AARTKDSQVL HKIIQSIFQT IVEQAPLAIE DIMNELDTQS
GEGEASDGDD GEASDGDDGE ASDDDDGEAS DGGDGDVADS DDSDGADDDD GDVSDGDGGD
NDEGDSNKSS EGEQDLQDTP PKKLPAGTAH RAGPEADKEQ AWDDEENAGP VLQFDYEALA
NRLFKLASRQ STPSQNRKRL YKVIQKLREL AGGTFPEDDV PEKAYKKMLE GRRERKKKKK
RLPKPQPQNK EAGSEAESSS ADPGPGRKRK RNRKTDEKAG QGGPPGKRRK PGARAKGAGA
QQPKKRIQSS QSAE
