ID   RRP41_HYPBU             Reviewed;         255 AA.
AC   A2BKC0;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Exosome complex component Rrp41 {ECO:0000255|HAMAP-Rule:MF_00591};
DE            EC=3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00591};
GN   Name=rrp41 {ECO:0000255|HAMAP-Rule:MF_00591}; OrderedLocusNames=Hbut_0571;
OS   Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales; Pyrodictiaceae;
OC   Hyperthermus.
OX   NCBI_TaxID=415426;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 5456 / JCM 9403 / PLM1-5;
RX   PubMed=17350933; DOI=10.1155/2007/745987;
RA   Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A., Awayez M.,
RA   She Q., Garrett R.A., Klenk H.-P.;
RT   "The genome of Hyperthermus butylicus: a sulfur-reducing, peptide
RT   fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C.";
RL   Archaea 2:127-135(2007).
CC   -!- FUNCTION: Catalytic component of the exosome, which is a complex
CC       involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can
CC       also synthesize heteromeric RNA-tails. {ECO:0000255|HAMAP-
CC       Rule:MF_00591}.
CC   -!- SUBUNIT: Component of the archaeal exosome complex. Forms a hexameric
CC       ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The
CC       hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00591}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00591}.
CC   -!- SIMILARITY: Belongs to the RNase PH family. Rrp41 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00591}.
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DR   EMBL; CP000493; ABM80431.1; -; Genomic_DNA.
DR   RefSeq; WP_011821749.1; NC_008818.1.
DR   AlphaFoldDB; A2BKC0; -.
DR   SMR; A2BKC0; -.
DR   STRING; 415426.Hbut_0571; -.
DR   EnsemblBacteria; ABM80431; ABM80431; Hbut_0571.
DR   GeneID; 4782637; -.
DR   KEGG; hbu:Hbut_0571; -.
DR   eggNOG; arCOG01575; Archaea.
DR   HOGENOM; CLU_063514_0_0_2; -.
DR   OMA; KGKGQGW; -.
DR   OrthoDB; 57069at2157; -.
DR   Proteomes; UP000002593; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd11366; RNase_PH_archRRP41; 1.
DR   Gene3D; 3.30.230.70; -; 1.
DR   HAMAP; MF_00591; Exosome_Rrp41; 1.
DR   InterPro; IPR001247; ExoRNase_PH_dom1.
DR   InterPro; IPR015847; ExoRNase_PH_dom2.
DR   InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR   InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR011807; Rrp41.
DR   Pfam; PF01138; RNase_PH; 1.
DR   Pfam; PF03725; RNase_PH_C; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55666; SSF55666; 1.
DR   TIGRFAMs; TIGR02065; ECX1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Exosome; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..255
FT                   /note="Exosome complex component Rrp41"
FT                   /id="PRO_1000146956"
SQ   SEQUENCE   255 AA;  27786 MW;  4AC9EF94041D7568 CRC64;
     MAGGAGEKPT LIRWEERDGQ KVAIRHDGRL PEQLRPIRME VGVLSNADGS ALVEYGGTRV
     IAAVYGPREA HPRHVALPDR AIIRCRYHMA PFSTAERKTP APTRREVELS KVIREALEAV
     VISELYPRTA IDVYMEVLQS DGGTRTAAIT AASLALADAG IAMRDLVAGV AVGKVDGVLV
     LDIDEIEDNY AEADMPVAMA PSLDKVLLLQ LNGVLTHDEF VKALELARKG IQVIYNLQKE
     ALRKKYVEVS VEEGA