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RRP41_METKA
ID   RRP41_METKA             Reviewed;         239 AA.
AC   Q8TYC1;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Exosome complex component Rrp41 {ECO:0000255|HAMAP-Rule:MF_00591};
DE            EC=3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00591};
GN   Name=rrp41 {ECO:0000255|HAMAP-Rule:MF_00591}; OrderedLocusNames=MK0381;
OS   Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC   Archaea; Euryarchaeota; Methanopyri; Methanopyrales; Methanopyraceae;
OC   Methanopyrus.
OX   NCBI_TaxID=190192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938;
RX   PubMed=11930014; DOI=10.1073/pnas.032671499;
RA   Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA   Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA   Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA   Koonin E.V., Kozyavkin S.A.;
RT   "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT   monophyly of archaeal methanogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
CC   -!- FUNCTION: Catalytic component of the exosome, which is a complex
CC       involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can
CC       also synthesize heteromeric RNA-tails. {ECO:0000255|HAMAP-
CC       Rule:MF_00591}.
CC   -!- SUBUNIT: Component of the archaeal exosome complex. Forms a hexameric
CC       ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The
CC       hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00591}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00591}.
CC   -!- SIMILARITY: Belongs to the RNase PH family. Rrp41 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00591}.
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DR   EMBL; AE009439; AAM01596.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8TYC1; -.
DR   SMR; Q8TYC1; -.
DR   STRING; 190192.MK0381; -.
DR   EnsemblBacteria; AAM01596; AAM01596; MK0381.
DR   KEGG; mka:MK0381; -.
DR   PATRIC; fig|190192.8.peg.407; -.
DR   HOGENOM; CLU_063514_0_0_2; -.
DR   OMA; KGKGQGW; -.
DR   Proteomes; UP000001826; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd11366; RNase_PH_archRRP41; 1.
DR   Gene3D; 3.30.230.70; -; 1.
DR   HAMAP; MF_00591; Exosome_Rrp41; 1.
DR   InterPro; IPR001247; ExoRNase_PH_dom1.
DR   InterPro; IPR015847; ExoRNase_PH_dom2.
DR   InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR   InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR011807; Rrp41.
DR   Pfam; PF01138; RNase_PH; 1.
DR   Pfam; PF03725; RNase_PH_C; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55666; SSF55666; 1.
DR   TIGRFAMs; TIGR02065; ECX1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Exosome; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..239
FT                   /note="Exosome complex component Rrp41"
FT                   /id="PRO_0000139982"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   239 AA;  26515 MW;  204BA6A9F85D343D CRC64;
     MEERPERLIS EDGLRLDGRK PDEMRPLKIQ AGVLKRADGS AYLELGANKI VAAVYGPREL
     HPRHKQKPDR AVVRFRYNMA PFSVDERKRP GPDRRSIEIS KLSKEALEPA IFTEYYPRTA
     IDIFVEVLQA DAGTRCAGIS AASVALADAG IEMRDLVAAC AAGKVEGKVV LDPMYYEDGY
     GEADVPLAMM PKEGKITLLQ MDGDMTPGEF KQAVKLAKKG CKIVYKEQRR ALKEKYGGD
 
 
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