RRP41_PYRFU
ID RRP41_PYRFU Reviewed; 250 AA.
AC Q8U0L9;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Exosome complex component Rrp41 {ECO:0000255|HAMAP-Rule:MF_00591};
DE EC=3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00591};
GN Name=rrp41 {ECO:0000255|HAMAP-Rule:MF_00591}; OrderedLocusNames=PF1568;
OS Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=186497;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA DiRuggiero J., Robb F.T.;
RT "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT horikoshii inferred from complete genomic sequences.";
RL Genetics 152:1299-1305(1999).
CC -!- FUNCTION: Catalytic component of the exosome, which is a complex
CC involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can
CC also synthesize heteromeric RNA-tails. {ECO:0000255|HAMAP-
CC Rule:MF_00591}.
CC -!- SUBUNIT: Component of the archaeal exosome complex. Forms a hexameric
CC ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The
CC hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00591}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00591}.
CC -!- SIMILARITY: Belongs to the RNase PH family. Rrp41 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_00591}.
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DR EMBL; AE009950; AAL81692.1; -; Genomic_DNA.
DR RefSeq; WP_011012714.1; NZ_CP023154.1.
DR AlphaFoldDB; Q8U0L9; -.
DR SMR; Q8U0L9; -.
DR STRING; 186497.PF1568; -.
DR EnsemblBacteria; AAL81692; AAL81692; PF1568.
DR GeneID; 41713392; -.
DR KEGG; pfu:PF1568; -.
DR PATRIC; fig|186497.12.peg.1634; -.
DR eggNOG; arCOG01575; Archaea.
DR HOGENOM; CLU_063514_0_0_2; -.
DR OMA; KGKGQGW; -.
DR OrthoDB; 57069at2157; -.
DR PhylomeDB; Q8U0L9; -.
DR Proteomes; UP000001013; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006401; P:RNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd11366; RNase_PH_archRRP41; 1.
DR Gene3D; 3.30.230.70; -; 1.
DR HAMAP; MF_00591; Exosome_Rrp41; 1.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR015847; ExoRNase_PH_dom2.
DR InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR011807; Rrp41.
DR Pfam; PF01138; RNase_PH; 1.
DR Pfam; PF03725; RNase_PH_C; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55666; SSF55666; 1.
DR TIGRFAMs; TIGR02065; ECX1; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Exosome; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..250
FT /note="Exosome complex component Rrp41"
FT /id="PRO_0000139987"
SQ SEQUENCE 250 AA; 27848 MW; 88446797413FBE36 CRC64;
MMLKPEGLKL IDENGRRLDG RKKYELRPIK MKVGVLKNAN GSAYIEWGKN KIIAAVYGPR
EIHPKHLQRP DRAILRVRYN MAPFSVEERK KPGPDRRSIE ISKVIRGALE PALILEMFPR
TAIDVFIEVL QADAGTRVAG ITAASLALAD AGIPMRDLVA ACSAGKIEGE IVLDLNKEED
NYGEADVPVA IMPIKNDITL LQMDGYLTKE EFIEAVKLAI KGAKAVYQKQ REALKEKYLK
IAQEVEGSEQ