ID   RRP41_PYRNV             Reviewed;         246 AA.
AC   B1Y978;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Exosome complex component Rrp41 {ECO:0000255|HAMAP-Rule:MF_00591};
DE            EC=3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00591};
GN   Name=rrp41 {ECO:0000255|HAMAP-Rule:MF_00591}; OrderedLocusNames=Tneu_1381;
OS   Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 /
OS   V24Sta) (Thermoproteus neutrophilus).
OC   Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Pyrobaculum.
OX   NCBI_TaxID=444157;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Biddle J.F., Zhang Z., Fitz-Gibbon S.T., Lowe T.M.,
RA   Saltikov C., House C.H., Richardson P.;
RT   "Complete sequence of Thermoproteus neutrophilus V24Sta.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalytic component of the exosome, which is a complex
CC       involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can
CC       also synthesize heteromeric RNA-tails. {ECO:0000255|HAMAP-
CC       Rule:MF_00591}.
CC   -!- SUBUNIT: Component of the archaeal exosome complex. Forms a hexameric
CC       ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The
CC       hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00591}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00591}.
CC   -!- SIMILARITY: Belongs to the RNase PH family. Rrp41 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00591}.
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DR   EMBL; CP001014; ACB40307.1; -; Genomic_DNA.
DR   AlphaFoldDB; B1Y978; -.
DR   SMR; B1Y978; -.
DR   STRING; 444157.Tneu_1381; -.
DR   EnsemblBacteria; ACB40307; ACB40307; Tneu_1381.
DR   KEGG; tne:Tneu_1381; -.
DR   eggNOG; arCOG01575; Archaea.
DR   HOGENOM; CLU_063514_0_0_2; -.
DR   OMA; KGKGQGW; -.
DR   Proteomes; UP000001694; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd11366; RNase_PH_archRRP41; 1.
DR   Gene3D; 3.30.230.70; -; 1.
DR   HAMAP; MF_00591; Exosome_Rrp41; 1.
DR   InterPro; IPR001247; ExoRNase_PH_dom1.
DR   InterPro; IPR015847; ExoRNase_PH_dom2.
DR   InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR   InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR011807; Rrp41.
DR   Pfam; PF01138; RNase_PH; 1.
DR   Pfam; PF03725; RNase_PH_C; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55666; SSF55666; 1.
DR   TIGRFAMs; TIGR02065; ECX1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Exosome; Hydrolase; Nuclease.
FT   CHAIN           1..246
FT                   /note="Exosome complex component Rrp41"
FT                   /id="PRO_1000146960"
SQ   SEQUENCE   246 AA;  27028 MW;  E950A4EA6D0E09CE CRC64;
     MKKPPVPLLQ GGVRADGRAP DQMREVQISV GVISNADGSA MVSYGATTAV AAVYGPREMH
     PRHLSLPDRG VMRVRYHMAP FSTKDERKSP TPSRREIEIS KVLREALEPA VMLEQYPRSR
     IDVFIEILQA DGSTRVASLT AASLALADAG IYMRDLVIGV SVGLVDGTVV LDLNGLEDQY
     GEGDLPVGYM PNLRRYTLLQ LDGAWGRDKL LEALNLAVKG AEFVYQKARD ALKNRYMAIA
     EEIYGR