ID   RRP41_THEKO             Reviewed;         249 AA.
AC   Q5JIR6;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Exosome complex component Rrp41 {ECO:0000255|HAMAP-Rule:MF_00591};
DE            EC=3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00591};
GN   Name=rrp41 {ECO:0000255|HAMAP-Rule:MF_00591}; OrderedLocusNames=TK1634;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- FUNCTION: Catalytic component of the exosome, which is a complex
CC       involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can
CC       also synthesize heteromeric RNA-tails. {ECO:0000255|HAMAP-
CC       Rule:MF_00591}.
CC   -!- SUBUNIT: Component of the archaeal exosome complex. Forms a hexameric
CC       ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The
CC       hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00591}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00591}.
CC   -!- SIMILARITY: Belongs to the RNase PH family. Rrp41 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00591}.
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DR   EMBL; AP006878; BAD85823.1; -; Genomic_DNA.
DR   RefSeq; WP_011250585.1; NC_006624.1.
DR   AlphaFoldDB; Q5JIR6; -.
DR   SMR; Q5JIR6; -.
DR   STRING; 69014.TK1634; -.
DR   EnsemblBacteria; BAD85823; BAD85823; TK1634.
DR   GeneID; 3234973; -.
DR   KEGG; tko:TK1634; -.
DR   PATRIC; fig|69014.16.peg.1593; -.
DR   eggNOG; arCOG01575; Archaea.
DR   HOGENOM; CLU_063514_0_0_2; -.
DR   InParanoid; Q5JIR6; -.
DR   OMA; KGKGQGW; -.
DR   OrthoDB; 57069at2157; -.
DR   PhylomeDB; Q5JIR6; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016075; P:rRNA catabolic process; IBA:GO_Central.
DR   CDD; cd11366; RNase_PH_archRRP41; 1.
DR   Gene3D; 3.30.230.70; -; 1.
DR   HAMAP; MF_00591; Exosome_Rrp41; 1.
DR   InterPro; IPR001247; ExoRNase_PH_dom1.
DR   InterPro; IPR015847; ExoRNase_PH_dom2.
DR   InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR   InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR011807; Rrp41.
DR   Pfam; PF01138; RNase_PH; 1.
DR   Pfam; PF03725; RNase_PH_C; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55666; SSF55666; 1.
DR   TIGRFAMs; TIGR02065; ECX1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Exosome; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..249
FT                   /note="Exosome complex component Rrp41"
FT                   /id="PRO_0000139989"
SQ   SEQUENCE   249 AA;  27628 MW;  A745E93C6832E2CF CRC64;
     MMGRPEGLKL IDENGKRIDG RKKYELRPIK MEVGVLKNAD GSAYVEWGKN KVLAAVYGPR
     EIHPKHLQRP DRAILRVRYN MAPFSVEERK KPGPDRRSVE ISKVIRGALE PALLLHMFPR
     TAIDVFIEIL QADAGTRVAG ITAASLALAD AGIPMKDLVA ACAAGKIDGE IVLDLNKEED
     NYGEADVPVA IMPLKNDITL LQMDGYLTKD EFLEAVRLAI KGAKAVYQKQ REALKEKYLK
     IAQEVEGNE