AX6A_TERSU
ID AX6A_TERSU Reviewed; 85 AA.
AC P0C1T6;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 31.
DE RecName: Full=Augerpeptide-s6a;
DE Short=Agx-s6a;
DE Flags: Precursor;
OS Terebra subulata (Chocolate spotted auger) (Buccinum subulatum).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Terebridae; Terebra.
OX NCBI_TaxID=89435;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 44-84, AND MASS
RP SPECTROMETRY.
RC TISSUE=Venom, and Venom duct;
RX PubMed=14505939; DOI=10.1016/s0041-0101(03)00169-7;
RA Imperial J.S., Watkins M., Chen P., Hillyard D.R., Cruz L.J., Olivera B.M.;
RT "The augertoxins: biochemical characterization of venom components from the
RT toxoglossate gastropod Terebra subulata.";
RL Toxicon 42:391-398(2003).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC -!- MASS SPECTROMETRY: Mass=4864.7; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:14505939};
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DR AlphaFoldDB; P0C1T6; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Direct protein sequencing;
KW Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..43
FT /evidence="ECO:0000269|PubMed:14505939"
FT /id="PRO_0000249193"
FT CHAIN 44..84
FT /note="Augerpeptide-s6a"
FT /id="PRO_0000249194"
FT DISULFID 54..65
FT /evidence="ECO:0000250"
FT DISULFID 58..70
FT /evidence="ECO:0000250"
FT DISULFID 64..81
FT /evidence="ECO:0000250"
SQ SEQUENCE 85 AA; 9820 MW; B441D9BA11101AAA CRC64;
MTLTMSTVVF FSLILLTLGL QPKDKDEGVM GRSRLGKRGL LMRSLDEELK SNDCPEYCPH
GNECCEHHEC RYDPWSRELK CLDSR