ID   RRP42_METAC             Reviewed;         266 AA.
AC   Q8TGX5;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Exosome complex component Rrp42 {ECO:0000255|HAMAP-Rule:MF_00622};
GN   Name=rrp42 {ECO:0000255|HAMAP-Rule:MF_00622}; OrderedLocusNames=MA_1776;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- FUNCTION: Non-catalytic component of the exosome, which is a complex
CC       involved in RNA degradation. Contributes to the structuring of the
CC       Rrp41 active site. {ECO:0000255|HAMAP-Rule:MF_00622}.
CC   -!- SUBUNIT: Component of the archaeal exosome complex. Forms a hexameric
CC       ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The
CC       hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00622}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00622}.
CC   -!- SIMILARITY: Belongs to the RNase PH family. Rrp42 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00622}.
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DR   EMBL; AE010299; AAM05182.1; -; Genomic_DNA.
DR   RefSeq; WP_011021779.1; NC_003552.1.
DR   AlphaFoldDB; Q8TGX5; -.
DR   SMR; Q8TGX5; -.
DR   STRING; 188937.MA_1776; -.
DR   EnsemblBacteria; AAM05182; AAM05182; MA_1776.
DR   GeneID; 1473665; -.
DR   KEGG; mac:MA_1776; -.
DR   HOGENOM; CLU_038194_0_0_2; -.
DR   InParanoid; Q8TGX5; -.
DR   OMA; PESVFEM; -.
DR   OrthoDB; 64101at2157; -.
DR   PhylomeDB; Q8TGX5; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0016075; P:rRNA catabolic process; IBA:GO_Central.
DR   CDD; cd11365; RNase_PH_archRRP42; 1.
DR   Gene3D; 3.30.230.70; -; 1.
DR   HAMAP; MF_00622; Exosome_Rrp42; 1.
DR   InterPro; IPR001247; ExoRNase_PH_dom1.
DR   InterPro; IPR015847; ExoRNase_PH_dom2.
DR   InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR   InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR020869; Rrp42_archaea.
DR   Pfam; PF01138; RNase_PH; 1.
DR   Pfam; PF03725; RNase_PH_C; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55666; SSF55666; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exosome; Reference proteome.
FT   CHAIN           1..266
FT                   /note="Exosome complex component Rrp42"
FT                   /id="PRO_0000139997"
SQ   SEQUENCE   266 AA;  28719 MW;  87BBA54440EF3326 CRC64;
     MKKMSEIIAT LKKDYIYNLM IKGKRQDGRG FKDFRDLKLE TNVIVKAEGS AKVTLGNTQV
     LVGVKLQTGT PFPDSQDEGV IITNLELNPI ASPEFEPGPP REEAIEMARV VDRGIRESGA
     IDIKKLCITV GESVWIVFID VHVLNDDGNI IDASCLAAIA ALMTTMVPNE QQGLGEDVPL
     AMKEMPVGIT IAKIGSKLMV DPSLDEEAVC ETKLTIVSSS DGSVAGMQKM GISPLTEAEL
     FEAIDLALEK AAELRGLYLE GLAKSE