ID   RRP42_PYRFU             Reviewed;         277 AA.
AC   Q8U0M0;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Exosome complex component Rrp42 {ECO:0000255|HAMAP-Rule:MF_00622};
GN   Name=rrp42 {ECO:0000255|HAMAP-Rule:MF_00622}; OrderedLocusNames=PF1567;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
CC   -!- FUNCTION: Non-catalytic component of the exosome, which is a complex
CC       involved in RNA degradation. Contributes to the structuring of the
CC       Rrp41 active site. {ECO:0000255|HAMAP-Rule:MF_00622}.
CC   -!- SUBUNIT: Component of the archaeal exosome complex. Forms a hexameric
CC       ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The
CC       hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00622}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00622}.
CC   -!- SIMILARITY: Belongs to the RNase PH family. Rrp42 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00622}.
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DR   EMBL; AE009950; AAL81691.1; -; Genomic_DNA.
DR   RefSeq; WP_011012713.1; NC_003413.1.
DR   AlphaFoldDB; Q8U0M0; -.
DR   SMR; Q8U0M0; -.
DR   STRING; 186497.PF1567; -.
DR   EnsemblBacteria; AAL81691; AAL81691; PF1567.
DR   GeneID; 1469443; -.
DR   KEGG; pfu:PF1567; -.
DR   PATRIC; fig|186497.12.peg.1633; -.
DR   eggNOG; arCOG01574; Archaea.
DR   HOGENOM; CLU_038194_0_0_2; -.
DR   OMA; PESVFEM; -.
DR   OrthoDB; 64101at2157; -.
DR   PhylomeDB; Q8U0M0; -.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd11365; RNase_PH_archRRP42; 1.
DR   Gene3D; 3.30.230.70; -; 1.
DR   HAMAP; MF_00622; Exosome_Rrp42; 1.
DR   InterPro; IPR001247; ExoRNase_PH_dom1.
DR   InterPro; IPR015847; ExoRNase_PH_dom2.
DR   InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR   InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR020869; Rrp42_archaea.
DR   Pfam; PF01138; RNase_PH; 1.
DR   Pfam; PF03725; RNase_PH_C; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55666; SSF55666; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exosome; Reference proteome.
FT   CHAIN           1..277
FT                   /note="Exosome complex component Rrp42"
FT                   /id="PRO_0000140003"
SQ   SEQUENCE   277 AA;  30497 MW;  8A71F6290E511280 CRC64;
     MSNDEIVAGI MRDYILNLLK EKKRIDDRGF EDYRPIEVEV GVIEKAEGSA LVKLGNTQVL
     VGIKATLGEP FPDTPNMGVM TTNVELVPLA SPTFEPGPPD ERAIELARVI DRGIRESRAL
     NLEKMVIAPG KIVRVVFIDV HVLDHDGNLM DAIGIGAIAA LLNARVPKVL YNEETGEVEI
     LEEKEPLPVE KIPISVTFAK IGNYLVVDPT LEEEQIMDGR LTITTDETGH ISAVQKSEGG
     AFKLEEVMYA VETAFKKAEE IRKIILNALE KANNSEE