RRP42_THEAC
ID RRP42_THEAC Reviewed; 260 AA.
AC Q9HIP1;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 25-MAR-2003, sequence version 2.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Exosome complex component Rrp42 {ECO:0000255|HAMAP-Rule:MF_00622};
GN Name=rrp42 {ECO:0000255|HAMAP-Rule:MF_00622}; OrderedLocusNames=Ta1294;
OS Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS 15155 / AMRC-C165).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC Thermoplasmataceae; Thermoplasma.
OX NCBI_TaxID=273075;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX PubMed=11029001; DOI=10.1038/35035069;
RA Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT acidophilum.";
RL Nature 407:508-513(2000).
CC -!- FUNCTION: Non-catalytic component of the exosome, which is a complex
CC involved in RNA degradation. Contributes to the structuring of the
CC Rrp41 active site. {ECO:0000255|HAMAP-Rule:MF_00622}.
CC -!- SUBUNIT: Component of the archaeal exosome complex. Forms a hexameric
CC ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The
CC hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00622}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00622}.
CC -!- SIMILARITY: Belongs to the RNase PH family. Rrp42 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_00622}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC12416.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL445067; CAC12416.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_010901699.1; NC_002578.1.
DR AlphaFoldDB; Q9HIP1; -.
DR SMR; Q9HIP1; -.
DR STRING; 273075.Ta1294m; -.
DR EnsemblBacteria; CAC12416; CAC12416; CAC12416.
DR GeneID; 1457094; -.
DR KEGG; tac:Ta1294; -.
DR eggNOG; arCOG01574; Archaea.
DR HOGENOM; CLU_038194_0_0_2; -.
DR OMA; PESVFEM; -.
DR OrthoDB; 64101at2157; -.
DR Proteomes; UP000001024; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR GO; GO:0006401; P:RNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd11365; RNase_PH_archRRP42; 1.
DR Gene3D; 3.30.230.70; -; 1.
DR HAMAP; MF_00622; Exosome_Rrp42; 1.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR015847; ExoRNase_PH_dom2.
DR InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR020869; Rrp42_archaea.
DR Pfam; PF01138; RNase_PH; 1.
DR Pfam; PF03725; RNase_PH_C; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55666; SSF55666; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exosome; Reference proteome.
FT CHAIN 1..260
FT /note="Exosome complex component Rrp42"
FT /id="PRO_0000140008"
SQ SEQUENCE 260 AA; 28362 MW; B55CEF7A17F0F6EC CRC64;
MVKESAEILS EIRKNYILST MKGGKRIDGR LPDEFRELTI IENYIPRANG SAYVALGNTR
VVAGVKIEAG EPFPDTPDQG VLTTNVELLP IAFPSFEAGP PNDLAIEVSR VVDRGIRESK
MISPEKLVIE QGKKVWIVFL DINVLDYDGN LIDASTIAAV AALRNAVVPA SKEGGEDFKL
PVSSTPISVT MVKIGDTLVC DPSLEEDQIC GGRITVTTTE DGHIRAMQKG EIGAFTVEDV
KKAVKMSLEV GKKLREKYFR