RRP42_THEGJ
ID RRP42_THEGJ Reviewed; 273 AA.
AC C5A2B8;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Exosome complex component Rrp42 {ECO:0000255|HAMAP-Rule:MF_00622};
GN Name=rrp42 {ECO:0000255|HAMAP-Rule:MF_00622}; OrderedLocusNames=TGAM_2035;
OS Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=593117;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15229 / JCM 11827 / EJ3;
RX PubMed=19558674; DOI=10.1186/gb-2009-10-6-r70;
RA Zivanovic Y., Armengaud J., Lagorce A., Leplat C., Guerin P., Dutertre M.,
RA Anthouard V., Forterre P., Wincker P., Confalonieri F.;
RT "Genome analysis and genome-wide proteomics of Thermococcus gammatolerans,
RT the most radioresistant organism known amongst the Archaea.";
RL Genome Biol. 10:R70.1-R70.23(2007).
CC -!- FUNCTION: Non-catalytic component of the exosome, which is a complex
CC involved in RNA degradation. Contributes to the structuring of the
CC Rrp41 active site. {ECO:0000255|HAMAP-Rule:MF_00622}.
CC -!- SUBUNIT: Component of the archaeal exosome complex. Forms a hexameric
CC ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The
CC hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00622}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00622}.
CC -!- SIMILARITY: Belongs to the RNase PH family. Rrp42 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_00622}.
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DR EMBL; CP001398; ACS34537.1; -; Genomic_DNA.
DR RefSeq; WP_015859640.1; NC_012804.1.
DR AlphaFoldDB; C5A2B8; -.
DR SMR; C5A2B8; -.
DR STRING; 593117.TGAM_2035; -.
DR PaxDb; C5A2B8; -.
DR EnsemblBacteria; ACS34537; ACS34537; TGAM_2035.
DR GeneID; 7988601; -.
DR KEGG; tga:TGAM_2035; -.
DR PATRIC; fig|593117.10.peg.2046; -.
DR eggNOG; arCOG01574; Archaea.
DR HOGENOM; CLU_038194_0_0_2; -.
DR OMA; PESVFEM; -.
DR OrthoDB; 64101at2157; -.
DR Proteomes; UP000001488; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR GO; GO:0006401; P:RNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd11365; RNase_PH_archRRP42; 1.
DR Gene3D; 3.30.230.70; -; 1.
DR HAMAP; MF_00622; Exosome_Rrp42; 1.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR015847; ExoRNase_PH_dom2.
DR InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR020869; Rrp42_archaea.
DR Pfam; PF01138; RNase_PH; 1.
DR Pfam; PF03725; RNase_PH_C; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55666; SSF55666; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exosome.
FT CHAIN 1..273
FT /note="Exosome complex component Rrp42"
FT /id="PRO_1000212295"
SQ SEQUENCE 273 AA; 29974 MW; 86C735ED8867EB5D CRC64;
MSDVEIMAGI MRDRILNLLK EGKRIDGRSF EEYRDIEIKT GFIEKAEGSA WVRLGGTRVL
VGIKVDVGEP FPDLPDRGVM TTNVELVPLA SPTFEPGPPD ERAIELARVI DRGIRESQAV
ELEKLVIVPG KLVRVVFIDV HVLDHDGNLF DATGLAAMAA LMTTKIPKVE YNEETGEIIK
LDEYEPLPVK HVPIPVTFAK IGSSIIVDPN LDEETVMDSR LTITTDETGH ISAVQKGEGG
SFKLEEVMYA IDTALKKADE LRKILLEAVG SAS