ID   AX7A_TERSU              Reviewed;          71 AA.
AC   P0C1T7;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Augerpeptide-s7a;
DE            Short=Agx-s7a;
DE   Flags: Precursor; Fragments;
OS   Terebra subulata (Chocolate spotted auger) (Buccinum subulatum).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Terebridae; Terebra.
OX   NCBI_TaxID=89435;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 30-69, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=14505939; DOI=10.1016/s0041-0101(03)00169-7;
RA   Imperial J.S., Watkins M., Chen P., Hillyard D.R., Cruz L.J., Olivera B.M.;
RT   "The augertoxins: biochemical characterization of venom components from the
RT   toxoglossate gastropod Terebra subulata.";
RL   Toxicon 42:391-398(2003).
CC   -!- FUNCTION: Elicits an uncoordinated twisting syndrome when injected into
CC       C.elegans, but has no effect on mice.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- MASS SPECTROMETRY: Mass=4290.2; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:14505939};
CC   -!- MASS SPECTROMETRY: Mass=4291.4; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:14505939};
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DR   AlphaFoldDB; P0C1T7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Knottin; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..29
FT                   /evidence="ECO:0000269|PubMed:14505939"
FT                   /id="PRO_0000249195"
FT   CHAIN           30..69
FT                   /note="Augerpeptide-s7a"
FT                   /id="PRO_0000249196"
FT   DISULFID        36..48
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..65
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..68
FT                   /evidence="ECO:0000250"
FT   NON_CONS        25..26
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   71 AA;  7722 MW;  A9B160EE17B2206B CRC64;
     MSALKFVLIC GLVLLLIETI PGVSLNLMRA TNRHQCDTND DCEEDECCVL VGGNVNNPGV
     QTRICLACSR K