ID   RRP44_CAEEL             Reviewed;         961 AA.
AC   Q17632;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Probable exosome complex exonuclease RRP44;
DE            EC=3.1.13.-;
DE   AltName: Full=Protein DIS3 homolog;
DE   AltName: Full=Ribosomal RNA-processing protein 44;
GN   Name=dis-3; ORFNames=C04G2.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Putative catalytic component of the RNA exosome complex which
CC       has 3'->5' exoribonuclease activity and participates in a multitude of
CC       cellular RNA processing and degradation events. dis-3 has both 3'-5'
CC       exonuclease and endonuclease activities (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA exosome complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z70718; CAA94677.2; -; Genomic_DNA.
DR   PIR; T18925; T18925.
DR   RefSeq; NP_501835.2; NM_069434.4.
DR   AlphaFoldDB; Q17632; -.
DR   SMR; Q17632; -.
DR   BioGRID; 42978; 6.
DR   STRING; 6239.C04G2.6; -.
DR   EPD; Q17632; -.
DR   PaxDb; Q17632; -.
DR   PeptideAtlas; Q17632; -.
DR   PRIDE; Q17632; -.
DR   EnsemblMetazoa; C04G2.6.1; C04G2.6.1; WBGene00001001.
DR   GeneID; 177875; -.
DR   KEGG; cel:CELE_C04G2.6; -.
DR   UCSC; C04G2.6; c. elegans.
DR   CTD; 177875; -.
DR   WormBase; C04G2.6; CE42607; WBGene00001001; dis-3.
DR   eggNOG; KOG2102; Eukaryota.
DR   GeneTree; ENSGT00530000063106; -.
DR   HOGENOM; CLU_002333_5_0_1; -.
DR   InParanoid; Q17632; -.
DR   OMA; VVKRNWR; -.
DR   OrthoDB; 1104619at2759; -.
DR   PhylomeDB; Q17632; -.
DR   Reactome; R-CEL-429958; mRNA decay by 3' to 5' exoribonuclease.
DR   Reactome; R-CEL-450385; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q17632; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00001001; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0000178; C:exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0000176; C:nuclear exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0004519; F:endonuclease activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016075; P:rRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR041505; Dis3_CSD2.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR002716; PIN_dom.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR033771; Rrp44_CSD1.
DR   InterPro; IPR033770; RRP44_S1.
DR   Pfam; PF17849; OB_Dis3; 1.
DR   Pfam; PF00773; RNB; 1.
DR   Pfam; PF17216; Rrp44_CSD1; 1.
DR   Pfam; PF17215; Rrp44_S1; 1.
DR   SMART; SM00670; PINc; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; SSF50249; 3.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Exosome; Hydrolase; Nuclease; Nucleus;
KW   Reference proteome; RNA-binding; rRNA processing.
FT   CHAIN           1..961
FT                   /note="Probable exosome complex exonuclease RRP44"
FT                   /id="PRO_0000166420"
FT   DOMAIN          73..188
FT                   /note="PINc"
FT   REGION          322..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   961 AA;  108786 MW;  D23F2FA6ADFF73A9 CRC64;
     MDLNVKQSGI HSVALHTTYF QNRSGKVYKR AEERYLRNDL SCGLAQCGTC KDFGTNPLLK
     IENPVRNAKV GRHALIVDST SLIRFYDLFD SSLLRDLIVT QTVWEGVKAK AVPAYKKMNS
     LCYEDAKDRF HVFMNEFHCE TFSESSKFED LSRGEELLLS TALYLKTHWQ KHNVAPVVLV
     FDEDSKKRME NHYQHVMYLK EYIQNLEDPG KQALLDQMAA YESSGNGNEK QIFDEYLSHD
     RIMEGIASGT IKRGNFSVSR ENYREATVII DDQLTSWFIT GNNCNRAVNG DTVAVQLLPE
     DQWTAPEKKI RLRDVEEYVK TADDMGNEDE ENDDENDEPK AKKSKKMTVS TAKVVGIIKR
     NWREYCGMLL PSTVKGARRH LFCPAERLIP RIRIETEQAE TLSQQRIVVA IDHWPRDSKY
     PLGHYVRSIG EMGSRETENE VLLLEHDIPH APFSESVLDC LPREEWEPDL TENRGPLPRV
     DLRDLTICSV DPLGCTDIDD ALHCKQIGED LFEVGVHIAD VTHFVRPGTA IDDEAALRGT
     TVYLCDRRID MLPCLLSSNL CSLRGEEERY AFSCIWTMTS SADIQSVKYH KSLIKSKAAL
     TYEKAQEIID DPKEQNDVAL GLRGLMKLSK VLNARRTGNG ALTLASSEVR FDMDWESRTP
     KKVMEKQHLD THSMVEEFML LANISVAEKI LEEYPDCALL RRHPVPLKES YKPLVEAARH
     RGFEIIVESG KGLADSLNRC VDKKNPMLNR LLRMLTTRCM TQAVYFSAGT VPVPQYQHFG
     LACAIYTHFT SPIRRYADVI VHRLLAAAIG ADDIQSGLLN QARCTKICTN INYRHKQAQY
     AGRASVQLNV VRYFKGKVET CEGFVMGVRN NGIQVFVPKY GLESIIVLQT SAASGTTIDV
     EEMSVKVNGD VVIKELEPVT VRISVNEKNQ QRPRVELQLI KPAIPGLSVD FDLSSSEGLG
     L