ID   RRP4_THEAM              Reviewed;         247 AA.
AC   D5U396;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Exosome complex component Rrp4 {ECO:0000255|HAMAP-Rule:MF_00623};
GN   Name=rrp4 {ECO:0000255|HAMAP-Rule:MF_00623}; OrderedLocusNames=Tagg_1335;
OS   Thermosphaera aggregans (strain DSM 11486 / M11TL).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Thermosphaera.
OX   NCBI_TaxID=633148;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 11486 / M11TL;
RX   DOI=10.4056/sigs.821804;
RA   Spring S., Rachel R., Lapidus A., Davenport K., Tice H., Copeland A.,
RA   Cheng J.-F., Lucas S., Chen F., Nolan M., Bruce D., Goodwin L., Pitluck S.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.-J., Jeffries C.C., Brettin T.,
RA   Detter J.C., Tapia R., Han C., Heimerl T., Weikl F., Brambilla E.,
RA   Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.-P.;
RT   "Complete genome sequence of Thermosphaera aggregans type strain
RT   (M11TLT).";
RL   Stand. Genomic Sci. 2:245-259(2010).
CC   -!- FUNCTION: Non-catalytic component of the exosome, which is a complex
CC       involved in RNA degradation. Increases the RNA binding and the
CC       efficiency of RNA degradation. Confers strong poly(A) specificity to
CC       the exosome. {ECO:0000255|HAMAP-Rule:MF_00623}.
CC   -!- SUBUNIT: Component of the archaeal exosome complex. Forms a trimer of
CC       Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-
CC       like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
CC       {ECO:0000255|HAMAP-Rule:MF_00623}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00623}.
CC   -!- SIMILARITY: Belongs to the RRP4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00623}.
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DR   EMBL; CP001939; ADG91596.1; -; Genomic_DNA.
DR   RefSeq; WP_013130189.1; NC_014160.1.
DR   AlphaFoldDB; D5U396; -.
DR   SMR; D5U396; -.
DR   STRING; 633148.Tagg_1335; -.
DR   EnsemblBacteria; ADG91596; ADG91596; Tagg_1335.
DR   GeneID; 9166383; -.
DR   KEGG; tag:Tagg_1335; -.
DR   eggNOG; arCOG00678; Archaea.
DR   HOGENOM; CLU_071769_0_0_2; -.
DR   OMA; GPYIPEV; -.
DR   OrthoDB; 93052at2157; -.
DR   Proteomes; UP000002376; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR   GO; GO:0008143; F:poly(A) binding; IEA:InterPro.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   HAMAP; MF_00623; Exosome_Rrp4; 1.
DR   InterPro; IPR026699; Exosome_RNA_bind1/RRP40/RRP4.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR023474; Rrp4.
DR   PANTHER; PTHR21321; PTHR21321; 1.
DR   Pfam; PF15985; KH_6; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exosome; Reference proteome; RNA-binding.
FT   CHAIN           1..247
FT                   /note="Exosome complex component Rrp4"
FT                   /id="PRO_0000416237"
FT   DOMAIN          75..148
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00623"
FT   DOMAIN          154..220
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00623"
SQ   SEQUENCE   247 AA;  27309 MW;  24BAB594769F119A CRC64;
     MKLKVIVADR QLVRPGDILA YIEEAGEVVK FKKIPDKHVY IFDNKIISDL VGVVNVSGED
     IQVIPLEGVY IPRKDDLVIG IVENVGVTAW TLDIRSPYPG VLNASEVIEG FNPLIHNLRN
     YLDTGDFVIG RIALFDRTRD PVITVKGKGL GKITEGVVVD VKPSKIPRLI GKRGSMYNLL
     TSMSGCEITI AQNGFVWLKC HDENRAKVLI QAIKLIELKA HMRGLTEEVK MFLERKLGGG
     GSGEHQA