RRP5_ARATH
ID RRP5_ARATH Reviewed; 1920 AA.
AC F4J8K6; Q9C7B6; Q9LHM6; Q9SF02;
DT 20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2016, sequence version 2.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=rRNA biogenesis protein RRP5 {ECO:0000303|PubMed:23382868};
DE Short=AtRrp5 {ECO:0000303|PubMed:23382868};
DE AltName: Full=Ribosomal RNA-processing protein 5 {ECO:0000303|PubMed:23382868};
GN Name=RRP5 {ECO:0000303|PubMed:23382868};
GN OrderedLocusNames=At3g11964 {ECO:0000312|Araport:AT3G11964};
GN ORFNames=F26K24.26 {ECO:0000312|EMBL:AAF23213.1},
GN T21B14.19 {ECO:0000312|EMBL:AAG51058.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=23382868; DOI=10.1371/journal.pone.0054084;
RA Missbach S., Weis B.L., Martin R., Simm S., Bohnsack M.T., Schleiff E.;
RT "40S ribosome biogenesis co-factors are essential for gametophyte and
RT embryo development.";
RL PLoS ONE 8:E54084-E54084(2013).
CC -!- FUNCTION: Involved in the biogenesis of ribosomal RNA (rRNA). Required
CC for the formation of 5.8S rRNA. Required for normal development of
CC female gametophytes. {ECO:0000269|PubMed:23382868}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:23382868}.
CC -!- TISSUE SPECIFICITY: Highly expressed in flowers and at lower levels in
CC roots, leaves, stems and siliques. {ECO:0000269|PubMed:23382868}.
CC -!- DISRUPTION PHENOTYPE: Aborted development of female gametophytes.
CC {ECO:0000269|PubMed:23382868}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF23213.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAG51058.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AEE75131.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAB03107.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC016795; AAF23213.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC069473; AAG51058.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP002040; BAB03107.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE75131.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; ANM64784.1; -; Genomic_DNA.
DR RefSeq; NP_001326789.1; NM_001337968.1.
DR RefSeq; NP_187803.4; NM_112030.4.
DR AlphaFoldDB; F4J8K6; -.
DR SMR; F4J8K6; -.
DR STRING; 3702.AT3G11964.1; -.
DR iPTMnet; F4J8K6; -.
DR PaxDb; F4J8K6; -.
DR PRIDE; F4J8K6; -.
DR ProteomicsDB; 226816; -.
DR EnsemblPlants; AT3G11964.2; AT3G11964.2; AT3G11964.
DR GeneID; 820370; -.
DR Gramene; AT3G11964.2; AT3G11964.2; AT3G11964.
DR KEGG; ath:AT3G11964; -.
DR Araport; AT3G11964; -.
DR TAIR; locus:2088644; AT3G11964.
DR eggNOG; KOG1070; Eukaryota.
DR HOGENOM; CLU_000845_1_1_1; -.
DR InParanoid; F4J8K6; -.
DR OMA; ANCEVGS; -.
DR OrthoDB; 23482at2759; -.
DR PRO; PR:F4J8K6; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; F4J8K6; baseline and differential.
DR GO; GO:0005730; C:nucleolus; IDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0009553; P:embryo sac development; IMP:TAIR.
DR GO; GO:0006364; P:rRNA processing; IMP:TAIR.
DR Gene3D; 1.25.40.10; -; 2.
DR Gene3D; 2.40.50.140; -; 10.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR045209; Rrp5.
DR InterPro; IPR022967; S1_dom.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR008847; Suf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR23270; PTHR23270; 1.
DR Pfam; PF00575; S1; 6.
DR Pfam; PF05843; Suf; 1.
DR SMART; SM00386; HAT; 4.
DR SMART; SM00316; S1; 15.
DR SUPFAM; SSF48452; SSF48452; 2.
DR SUPFAM; SSF50249; SSF50249; 12.
DR PROSITE; PS50126; S1; 14.
DR PROSITE; PS00283; SOYBEAN_KUNITZ; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing.
FT CHAIN 1..1920
FT /note="rRNA biogenesis protein RRP5"
FT /id="PRO_0000435322"
FT DOMAIN 128..210
FT /note="S1 motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 226..291
FT /note="S1 motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 314..384
FT /note="S1 motif 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 400..473
FT /note="S1 motif 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 490..557
FT /note="S1 motif 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 577..646
FT /note="S1 motif 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 661..733
FT /note="S1 motif 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 753..822
FT /note="S1 motif 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 866..930
FT /note="S1 motif 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 958..1031
FT /note="S1 motif 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 1054..1129
FT /note="S1 motif 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 1153..1224
FT /note="S1 motif 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 1260..1334
FT /note="S1 motif 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 1369..1438
FT /note="S1 motif 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 1459..1529
FT /note="S1 motif 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT REPEAT 1651..1683
FT /note="HAT 1"
FT /evidence="ECO:0000255"
FT REPEAT 1685..1722
FT /note="HAT 2"
FT /evidence="ECO:0000255"
FT REPEAT 1726..1758
FT /note="HAT 3"
FT /evidence="ECO:0000255"
FT REPEAT 1759..1791
FT /note="HAT 4"
FT /evidence="ECO:0000255"
FT REPEAT 1828..1860
FT /note="HAT 5"
FT /evidence="ECO:0000255"
FT REPEAT 1862..1897
FT /note="HAT 6"
FT /evidence="ECO:0000255"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1535..1555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1605..1652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1617..1652
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1920 AA; 214238 MW; 53FC04B2D5222D93 CRC64;
MVVPQKKFAN GKRNDSTKSF KPMKKPFKKT KDDVAARSEA MALQLEDVPD FPRGGGTSLS
KKEREKLYEE VDAEFDADER VSKKSKGGKS KKRIPSDLDD LGLLFGGGLH GKRPRYANKI
TTKNISPGMK LLGVVTEVNQ KDIVISLPGG LRGLVRASEV SDFTDRGIED DENELLGDIF
SVGQLVPCIV LELDDDKKEA GKRKIWLSLR LSLLHKGFSF DSFQLGMVFS ANVKSIEDHG
SILHFGLPSI TGFIEISDDG NQESGMKTGQ LIQGVVTKID RDRKIVHLSS DPDSVAKCLT
KDLSGMSFDL LIPGMMVNAR VQSVLENGIL FDFLTYFNGT VDLFHLKNPL SNKSWKDEYN
QNKTVNARIL FIDPSSRAVG LTLSPHVVCN KAPPLHVFSG DIFDEAKVVR IDKSGLLLEL
PSKPTPTPAY VSTYDAAGDE VTKLEKKFKE GNHIRVRVLG LKQMEGLAVG TLKESAFEGP
VFTHSDVKPG MVTKAKVISV DTFGAIVQFS GGLKAMCPLR HMSEFEVTKP RKKFKVGAEL
VFRVLGCKSK RITVTYKKTL VKSKLPILSS YTDATEGLVT HGWITKIEKH GCFVRFYNGV
QGFVPRFELG LEPGSDPDSV FHVGEVVKCR VTSAVHGTQR ITLSFMIKPS SVSEDDSIKL
GSIVSGIIDT ITSQAVIVRV KSKSVVKGTI SAEHLADHHE QAKLIMSLLR PGYELDKLLV
LDIEGNNMAL SSKYSLIKLA EELPSDFNQL QPNSVVHGYV CNLIENGCFV RFLGRLTGFA
PRSKAIDDPK ADVSESFFVG QSVRANIVDV NQEKSRITLS LKQSSCASVD ASFVQEYFLM
DEKISDLQSS DITKSDCSWV EKFSIGSLIK GTIQEQNDLG VVVNFDNINN VLGFIPQHHM
GGATLVPGSV VNAVVLDISR AERLVDLSLR PELLNNLTKE VSNSSKKKRK RGISKELEVH
QRVSAVVEIV KEQHLVLSIP EHGYTIGYAS VSDYNTQKLP VKQFSTGQSV VASVKAVQNP
LTSGRLLLLL DSVSGTSETS RSKRAKKKSS CEVGSVVHAE ITEIKPFELR VNFGNSFRGR
IHITEVNDAS TSDEPFAKFR VGQSISARVV AKPCHTDIKK TQLWELSVKP AMLKDSSEFN
DTQESEQLEF AAGQCVIGYV YKVDKEWVWL AVSRNVTARI FILDTSCKAH ELEEFERRFP
IGKAVSGYVL TYNKEKKTLR LVQRPLLFIH KSIANGGGSK TDKPDSSIPG DDDTLFIHEG
DILGGRISKI LPGVGGLRVQ LGPYVFGRVH FTEINDSWVP DPLDGFREGQ FVKCKVLEIS
SSSKGTWQIE LSLRTSLDGM SSADHLSEDL KNNDNVCKRF ERIEDLSPDM GVQGYVKNTM
SKGCFIILSR TVEAKVRLSN LCDTFVKEPE KEFPVGKLVT GRVLNVEPLS KRIEVTLKTV
NAGGRPKSES YDLKKLHVGD MISGRIRRVE PFGLFIDIDQ TGMVGLCHIS QLSDDRMENV
QARYKAGESV RAKILKLDEE KKRISLGMKS SYLMNGDDDK AQPLSEDNTS MECDPINDPK
SEVLAAVDDF GFQETSGGTS LVLAQVESRA SIPPLEVDLD DIEETDFDSS QNQEKLLGAN
KDEKSKRREK QKDKEEREKK IQAAEGRLLE HHAPENADEF EKLVRSSPNS SFVWIKYMAF
MLSLADIEKA RSIAERALRT INIREEEEKL NIWVAYFNLE NEHGNPPEES VKKVFERARQ
YCDPKKVYLA LLGVYERTEQ YKLADKLLDE MIKKFKQSCK IWLRKIQSSL KQNEEAIQSV
VNRALLCLPR HKHIKFISQT AILEFKCGVA DRGRSLFEGV LREYPKRTDL WSVYLDQEIR
LGEDDVIRSL FERAISLSLP PKKMKFLFKK FLEYEKSVGD EERVEYVKQR AMEYANSTLA
