RRP5_MOUSE
ID RRP5_MOUSE Reviewed; 1862 AA.
AC Q6NS46; Q3TSU4; Q3UGG2; Q3URK0; Q6PIA8; Q6ZQH2; Q7TPE2; Q9CTD8; Q9R1Z2;
AC Q9WTU7;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Protein RRP5 homolog;
DE AltName: Full=Apoptosis-linked gene 4 protein;
DE AltName: Full=Programmed cell death protein 11;
GN Name=Pdcd11; Synonyms=Alg4, Kiaa0185;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Embryonic brain, Eye, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1438, AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1568-1862.
RC STRAIN=C57BL/6J;
RC TISSUE=Embryo, Embryonic spinal cord, Embryonic testis, and Melanocyte;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 394-1163, AND TISSUE SPECIFICITY.
RX PubMed=10229231; DOI=10.1038/8420;
RA Lacana' E., D'Adamio L.;
RT "Regulation of Fas ligand expression and cell death by apoptosis-linked
RT gene 4.";
RL Nat. Med. 5:542-547(1999).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1468 AND SER-1490, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Lung, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Essential for the generation of mature 18S rRNA, specifically
CC necessary for cleavages at sites A0, 1 and 2 of the 47S precursor.
CC Directly interacts with U3 snoRNA (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with NF-kappa-B p50/NFKB1 and NF-kappa-B p65/RELA.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10229231}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD20941.1; Type=Miscellaneous discrepancy; Note=The mRNA 5'- and 3'-ends do not match to the genomic DNA.; Evidence={ECO:0000305};
CC Sequence=BAB23064.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC97890.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK129080; BAC97890.1; ALT_INIT; mRNA.
DR EMBL; BC038503; AAH38503.1; -; mRNA.
DR EMBL; BC055276; AAH55276.3; -; mRNA.
DR EMBL; BC070468; AAH70468.1; -; mRNA.
DR EMBL; AK003899; BAB23064.2; ALT_INIT; mRNA.
DR EMBL; AK141450; BAE24688.1; -; mRNA.
DR EMBL; AK147950; BAE28246.1; -; mRNA.
DR EMBL; AK161803; BAE36581.1; -; mRNA.
DR EMBL; AF055668; AAD20941.1; ALT_SEQ; mRNA.
DR EMBL; AF055669; AAD20942.1; -; mRNA.
DR CCDS; CCDS29888.1; -.
DR RefSeq; NP_035183.2; NM_011053.2.
DR AlphaFoldDB; Q6NS46; -.
DR SMR; Q6NS46; -.
DR BioGRID; 202073; 33.
DR STRING; 10090.ENSMUSP00000072008; -.
DR iPTMnet; Q6NS46; -.
DR PhosphoSitePlus; Q6NS46; -.
DR SwissPalm; Q6NS46; -.
DR EPD; Q6NS46; -.
DR jPOST; Q6NS46; -.
DR MaxQB; Q6NS46; -.
DR PaxDb; Q6NS46; -.
DR PeptideAtlas; Q6NS46; -.
DR PRIDE; Q6NS46; -.
DR ProteomicsDB; 299898; -.
DR Antibodypedia; 31534; 46 antibodies from 16 providers.
DR DNASU; 18572; -.
DR Ensembl; ENSMUST00000072141; ENSMUSP00000072008; ENSMUSG00000025047.
DR GeneID; 18572; -.
DR KEGG; mmu:18572; -.
DR UCSC; uc008hup.1; mouse.
DR CTD; 22984; -.
DR MGI; MGI:1341788; Pdcd11.
DR VEuPathDB; HostDB:ENSMUSG00000025047; -.
DR eggNOG; KOG1070; Eukaryota.
DR GeneTree; ENSGT00390000012228; -.
DR HOGENOM; CLU_000845_1_1_1; -.
DR InParanoid; Q6NS46; -.
DR OMA; GQYLRAY; -.
DR OrthoDB; 23482at2759; -.
DR PhylomeDB; Q6NS46; -.
DR TreeFam; TF105697; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 18572; 24 hits in 79 CRISPR screens.
DR ChiTaRS; Pdcd11; mouse.
DR PRO; PR:Q6NS46; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q6NS46; protein.
DR Bgee; ENSMUSG00000025047; Expressed in cleaving embryo and 232 other tissues.
DR Genevisible; Q6NS46; MM.
DR GO; GO:0005829; C:cytosol; IDA:MGI.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0051059; F:NF-kappaB binding; ISO:MGI.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 2.40.50.140; -; 9.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR045209; Rrp5.
DR InterPro; IPR022967; S1_dom.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR008847; Suf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR23270; PTHR23270; 4.
DR Pfam; PF00575; S1; 4.
DR Pfam; PF05843; Suf; 1.
DR SMART; SM00386; HAT; 7.
DR SMART; SM00316; S1; 13.
DR SUPFAM; SSF48452; SSF48452; 2.
DR SUPFAM; SSF50249; SSF50249; 11.
DR PROSITE; PS50126; S1; 12.
PE 1: Evidence at protein level;
KW Acetylation; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; rRNA processing; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q14690"
FT CHAIN 2..1862
FT /note="Protein RRP5 homolog"
FT /id="PRO_0000364200"
FT DOMAIN 83..171
FT /note="S1 motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 187..258
FT /note="S1 motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 281..346
FT /note="S1 motif 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 365..436
FT /note="S1 motif 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 453..522
FT /note="S1 motif 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 542..611
FT /note="S1 motif 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 636..707
FT /note="S1 motif 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 729..798
FT /note="S1 motif 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 846..911
FT /note="S1 motif 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 1047..1120
FT /note="S1 motif 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 1160..1233
FT /note="S1 motif 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 1241..1309
FT /note="S1 motif 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 1335..1407
FT /note="S1 motif 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT REPEAT 1590..1622
FT /note="HAT 1"
FT REPEAT 1696..1728
FT /note="HAT 2"
FT REPEAT 1766..1798
FT /note="HAT 3"
FT REPEAT 1800..1835
FT /note="HAT 4"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 999..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1406..1520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1545..1577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1031
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1420..1509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1546..1577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q14690"
FT MOD_RES 7
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q14690"
FT MOD_RES 438
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q14690"
FT MOD_RES 1468
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1490
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CROSSLNK 1424
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q14690"
FT CONFLICT 38
FT /note="E -> A (in Ref. 3; BAE28246)"
FT /evidence="ECO:0000305"
FT CONFLICT 187
FT /note="G -> D (in Ref. 3; BAE28246)"
FT /evidence="ECO:0000305"
FT CONFLICT 531
FT /note="S -> P (in Ref. 1; BAC97890)"
FT /evidence="ECO:0000305"
FT CONFLICT 919
FT /note="T -> P (in Ref. 1; BAC97890)"
FT /evidence="ECO:0000305"
FT CONFLICT 1027..1028
FT /note="Missing (in Ref. 1; BAC97890)"
FT /evidence="ECO:0000305"
FT CONFLICT 1337
FT /note="L -> H (in Ref. 3; BAE28246)"
FT /evidence="ECO:0000305"
FT CONFLICT 1469..1471
FT /note="ESE -> TRP (in Ref. 2; AAH38503)"
FT /evidence="ECO:0000305"
FT CONFLICT 1519
FT /note="E -> Q (in Ref. 2; AAH38503)"
FT /evidence="ECO:0000305"
FT CONFLICT 1556
FT /note="P -> L (in Ref. 1; BAC97890 and 2; AAH38503)"
FT /evidence="ECO:0000305"
FT CONFLICT 1851
FT /note="E -> D (in Ref. 2; AAH70468)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1862 AA; 207779 MW; F2045A86EE8C9626 CRC64;
MANLEESFPR GGTRKLHKSE KSSQQVVEQD NLFDVSTEEG PIKRKKSQKG PAKTKKLKIE
KRKSIKSIKE KFEILSLESL CEGMRILGCV KEVSELELVV SLPNGLQGFV QVTEVCDAYT
QKLNEQVAQE EPLEDLLRLP ELFSPGMLVR CVVSSLDVTE SGKKSVKLSV NPKRVNKVLS
ADALRPGMLL TGTVSSLEDH GYLVDIGVGG TRAFLSLKKA QEYIRQKNKG AKFKVGQYLT
CVVEEVKSNG GVVSLSVEHS EVSSAFATEE QSWNLNNLLP GLLVKAQVQK VTQFGLQLNF
LTFFKGLVDF MHLEPKKMGS YSSNQTVKAC ILCVHPRTRV VRLSLRPIFL HPGRPLTRIS
YQQLGAVLDD VPVQGFFKNA GAIFRLKDGV LAYARVSHLS DSKKAFNAEA FKPGSTHKCR
IIDYSQMDEL ALLSLRKSII AAPFLRYHDI KIGTVVKGTV LAIKPFGILV KVGEQIKGLV
PSMHLADIMM KNPEKKYSPG DEVKCRVLLC DPEAKKLIMT LKKTLVTSKL SLITCYEGAK
PGLQTHGVII RVKDYGCIVK FYNDVQGLVP KHELSTQHIP DPETVFYTGQ VVKVAVLSCE
PSKERMLLSF RLLSDSRPKD PGVESSQKKT GAVRIGQLVD VKVLEKTKTG LEVAILPHNT
PAFLPTPHLS DHAANGPLLH HWLQTGDTLH RVLCLSQSER HILLCRKPAL VSTVEGGQDP
KSLSEIQPGM LLIGFVKCIK EYGVFVQFPS GLSGLSPKTI MSDKFVTTPS EHFVEGQTVV
AKVTNVDESK QRMLLSLRLS DCSLGDSAST SFLLLCQCLE ELQGIRSLMS NQDSVLIQTL
ADMTPGMVLD AVVHEVLEDG SVVFSSDPVP DLVLRASRYH RAGQEVEPGQ KKKVVVLHVD
MLKLEVHVSL HQDLVNRKTR KLRKSSRHQG IVQHLEESFA VASLVETGHL VAFSLISHLN
DTFHFDSEKL RVGQGVCLTL KTTEPGVTGL ILAVEGPASK RTRMPVQRDS ETVDDKGEEK
EEEEEEEEKE EENLTVKSKK RHSLAIGDKV TGTIKAVKAT HVVVTLADGF VGCIHASRIL
DDVPVGTSPT TTLKAGKKVT ARVIGGRDVK TSKFLPISHP RFVLTILELS VRPSELKGSY
SALNTHSESP VEKIRQYQAG QTVTCFFKKY NVMKKWLEVD IGPDIRGRIP LLLTSLSFKV
LKHPDKKFQV GQAIEATVVD PDVPRAFLCL SLIGPYRLEE GEVAMGRVMK VVPNRGLTVS
FPFGKIGKVS MFHLSDSYSE APLEDFCPQK IVRCYILSTA HRVLALSLRS SRTNRETKNR
IEDPEINSIE DVKEGQLLRG YVKCVLPSSV IIGLGPSVLG LAKYSHVSEC VPPEKELYNG
CLPEGKLVTA KVLRVNPMKN LIELSLLPSD TGRPDVFSPA PEPKQEERSG GAEEGQKRKE
KNQKRREEKE EPQKSQRGGR GKRERQESES EQELVNKRPK KSGAAEEDDS GVEVYYREGE
DEVGEPKLPP RGKQTKSTEV PRLHLSSGFL WDVGLDSLTP ALPLREESSD SEDEQPHQAK
KKKGKKEREL EKQKAEKELS RIEEALMDPG RQPESADDFD RLVLSSPNSS ILWLQYMAFH
LQATEIEKAR AVAERALKTI SFREEQEKLN VWVALLNLEN MYGSQESLTK VFERAVQYNE
PLKVFLHLAD IYTKSEKYKE AGELYNRMLK RFRQEKAVWI KYGAFVLGRS QAGASHRVLQ
RALECLPAKE HVDVIVKFAQ LEFQLGDVER AKAIFENTLS TYPKRTDVWS VYIDMTIKHG
SQTAVRDIFE RVIHLSLAPK RMKFFFKRYL DYEKQHGTEK DVQAVKAKAL EYVEAKSSAL
ED
