ID   AXDN1_MACFA             Reviewed;         855 AA.
AC   Q95LP5; Q4R371; Q95K20;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 2.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Axonemal dynein light chain domain-containing protein 1;
GN   Name=AXDND1; ORFNames=QtsA-11085, QtsA-15492, QtsA-19166;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RA   Hashimoto K., Osada N., Hida M., Kusuda J., Tanuma R., Hirai M., Terao K.,
RA   Sugano S.;
RT   "Isolation of novel full-length cDNA clones from macaque testis cDNA
RT   libraries.";
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q95LP5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q95LP5-2; Sequence=VSP_024709, VSP_024712;
CC       Name=3;
CC         IsoId=Q95LP5-3; Sequence=VSP_024710, VSP_024711;
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DR   EMBL; AB070007; BAB62952.1; -; mRNA.
DR   EMBL; AB072743; BAB69712.1; -; mRNA.
DR   EMBL; AB179396; BAE02447.1; -; mRNA.
DR   AlphaFoldDB; Q95LP5; -.
DR   SMR; Q95LP5; -.
DR   STRING; 9541.XP_005540173.1; -.
DR   PRIDE; Q95LP5; -.
DR   eggNOG; ENOG502QSV4; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   InterPro; IPR019347; Axonemal_dynein_light_chain.
DR   Pfam; PF10211; Ax_dynein_light; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Reference proteome.
FT   CHAIN           1..855
FT                   /note="Axonemal dynein light chain domain-containing
FT                   protein 1"
FT                   /id="PRO_0000284869"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          316..402
FT                   /evidence="ECO:0000255"
FT   COILED          451..480
FT                   /evidence="ECO:0000255"
FT   COILED          571..596
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..246
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_024709"
FT   VAR_SEQ         521..528
FT                   /note="MLNEKKEE -> IRPEEEAG (in isoform 3)"
FT                   /evidence="ECO:0000303|Ref.3"
FT                   /id="VSP_024710"
FT   VAR_SEQ         529..855
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|Ref.3"
FT                   /id="VSP_024711"
FT   VAR_SEQ         847..855
FT                   /note="LCSRRILLP -> QEDEEESKEDRKLQEENKEKAEEQPSTSTEEEKLIRFIG
FT                   EDENVHSKPLFETDVLSSWKESAKQGTLAQKYLEAMAVIEHMQEKLLEVEKRAKQAEE
FT                   (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_024712"
FT   CONFLICT        36
FT                   /note="L -> I (in Ref. 3; BAE02447)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        427
FT                   /note="K -> R (in Ref. 2; BAB69712)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        842
FT                   /note="M -> I (in Ref. 1; BAB62952)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   855 AA;  99517 MW;  A33F1ABFA4C219FD CRC64;
     MSLPKTPSTP LNSASTSESK KLVSVATEGT RGLPELKEKK NMVDRSKPLP TSLLNEFIPK
     EVLLSLTYAA NAGPCPENLL PPKKIKTPKG TLPRLVDHVW HHPVRRNKFK YLIDHPVSLT
     GAGRDISFLY DVKYTKGQTR EKAVCPPHLA RSLQSHDGVI VPHKPKTLTD TLIPEEFHIV
     SSTGVSGLEC YDDKYTTLLT DSENRLLLFP SMKPNKRVEV AQLNDVMDTM LERAGVENQE
     YTGPTKMHKL LHILKKEQTI YNTIFHELIR QVSVDCADRG ELLSKVRERY VQMLDQIARQ
     MIDFYKDLVT QRVMDQRILE ELYNFKHVIE ELTRELCLVR AHDVKLTKET EKAHKDLAQA
     LLDAEKNAKM VEEYHDLYTL QRERMENDMK QLMAERDIWS SATYELALKV IERNRVILAR
     RLYLNEKGWN KYTKHLIILL ANKDTEDLAL LQKLTQKWRN LVNKFKQEVE EMEESTRETL
     KIVEKGLTKW QESFNEKDIL SPNNGNVFDS VILDFKQWQK MLNEKKEEFT GDVLLSKYDT
     LKIIKHLQEN WTDIGLGIFN RHKSLEGELP SERQYMEEII KNIQKLYKEY EIRINGDNGY
     SKILPILISS LDFCSFKLEN LEFPDTPLEE WQEIDEKINE MKLQLDLLLN LTGIVPQHID
     MDSVSVLQAY IFNMIQQWLL KIGNEINNGN IELQRHMDEL HISMIQWMVN LLILMIPNFT
     DQDCLLKLEE ESAEKHDIGV ARLELDAIEL TRKLYQYSRY LSSSCEGMVT AMALSKSTTS
     HRNATEDLYE VDKLKKECYE WINTCSCLLS NIKGRKITLL TYEEIEQLLE EEAVKEFIEP
     EMDESLLCSR RILLP