RRP7A_MOUSE
ID RRP7A_MOUSE Reviewed; 280 AA.
AC Q9D1C9; Q3TWT8; Q8CCK8;
DT 24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Ribosomal RNA-processing protein 7 homolog A;
DE AltName: Full=Gastric cancer antigen Zg14 homolog;
GN Name=Rrp7a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, DBA/2J, and NOD;
RC TISSUE=Amnion, Cerebellum, Heart, Olfactory bulb, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Nucleolar protein that is involved in ribosomal RNA (rRNA)
CC processing. Also plays a role in primary cilia resorption, and cell
CC cycle progression in neurogenesis and neocortex development.
CC {ECO:0000250|UniProtKB:Q9Y3A4}.
CC -!- SUBUNIT: Interacts with NOL6; required for NOL6 localization to
CC nucleolus. {ECO:0000250|UniProtKB:Q9Y3A4}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q9Y3A4}. Cell projection, cilium
CC {ECO:0000250|UniProtKB:Q9Y3A4}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000250|UniProtKB:Q9Y3A4}.
CC -!- SIMILARITY: Belongs to the RRP7 family. {ECO:0000305}.
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DR EMBL; AK003698; BAB22944.1; -; mRNA.
DR EMBL; AK032596; BAC27942.1; -; mRNA.
DR EMBL; AK036247; BAC29360.1; -; mRNA.
DR EMBL; AK088456; BAC40363.1; -; mRNA.
DR EMBL; AK146821; BAE27459.1; -; mRNA.
DR EMBL; AK159553; BAE35178.1; -; mRNA.
DR EMBL; AK168189; BAE40149.1; -; mRNA.
DR EMBL; AK168850; BAE40672.1; -; mRNA.
DR EMBL; BC012523; AAH12523.1; -; mRNA.
DR CCDS; CCDS27696.1; -.
DR RefSeq; NP_083377.3; NM_029101.4.
DR AlphaFoldDB; Q9D1C9; -.
DR SMR; Q9D1C9; -.
DR BioGRID; 217014; 3.
DR STRING; 10090.ENSMUSP00000018184; -.
DR iPTMnet; Q9D1C9; -.
DR PhosphoSitePlus; Q9D1C9; -.
DR EPD; Q9D1C9; -.
DR MaxQB; Q9D1C9; -.
DR PaxDb; Q9D1C9; -.
DR PRIDE; Q9D1C9; -.
DR ProteomicsDB; 299899; -.
DR Antibodypedia; 277; 131 antibodies from 26 providers.
DR Ensembl; ENSMUST00000018184; ENSMUSP00000018184; ENSMUSG00000018040.
DR GeneID; 74778; -.
DR KEGG; mmu:74778; -.
DR UCSC; uc007wzy.3; mouse.
DR CTD; 27341; -.
DR MGI; MGI:1922028; Rrp7a.
DR VEuPathDB; HostDB:ENSMUSG00000018040; -.
DR eggNOG; KOG4008; Eukaryota.
DR GeneTree; ENSGT00390000018482; -.
DR HOGENOM; CLU_036234_2_1_1; -.
DR InParanoid; Q9D1C9; -.
DR OMA; FIRLMDP; -.
DR OrthoDB; 1607176at2759; -.
DR PhylomeDB; Q9D1C9; -.
DR TreeFam; TF313949; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 74778; 27 hits in 73 CRISPR screens.
DR ChiTaRS; Rrp7a; mouse.
DR PRO; PR:Q9D1C9; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9D1C9; protein.
DR Bgee; ENSMUSG00000018040; Expressed in dentate gyrus of hippocampal formation granule cell and 72 other tissues.
DR ExpressionAtlas; Q9D1C9; baseline and differential.
DR Genevisible; Q9D1C9; MM.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0032545; C:CURI complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0034456; C:UTP-C complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0001825; P:blastocyst formation; IMP:MGI.
DR GO; GO:0061523; P:cilium disassembly; ISS:UniProtKB.
DR GO; GO:1902570; P:protein localization to nucleolus; ISO:MGI.
DR GO; GO:0000028; P:ribosomal small subunit assembly; IBA:GO_Central.
DR GO; GO:0042254; P:ribosome biogenesis; ISS:UniProtKB.
DR GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR CDD; cd12294; RRM_Rrp7A; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR040447; RRM_Rrp7.
DR InterPro; IPR040446; RRP7.
DR InterPro; IPR024326; RRP7_C.
DR InterPro; IPR034890; Rrp7A_RRM.
DR PANTHER; PTHR13191; PTHR13191; 1.
DR Pfam; PF17799; RRM_Rrp7; 1.
DR Pfam; PF12923; RRP7; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein;
KW Reference proteome; RNA-binding.
FT CHAIN 1..280
FT /note="Ribosomal RNA-processing protein 7 homolog A"
FT /id="PRO_0000082009"
FT DOMAIN 61..90
FT /note="RRM"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 99
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A4"
FT CONFLICT 103
FT /note="P -> Q (in Ref. 1; BAC27942)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 280 AA; 32399 MW; 4F2D324221B2AA3F CRC64;
MVSRRKKRKA GGHEESIPSP PGYSAVPVKF SAKQQAPHYL YMRQHRVRQG TQSTWPPDRT
LFILNVPPYC TQESLSRCLS CCGTIKTVEL QEKPDLAESP TEPKSQFFHP KPVPGFQVAY
VVFQKPSGVS AALNLKGPLL VSTESHLVKS GIHKWISDYE DSVLDPEALR MEVDAFMEAY
DKKIAEEEAK AKEEEGVPDE EGWVKVTRRG RRPVLPRTEA ASLRVLEKEK RKRARKELLN
FYAWQHRETK MEHLAQLRKK FEEDKQRIEL MRAQRKFRPY
