ID   RRP7A_PONAB             Reviewed;         280 AA.
AC   Q5RA17;
DT   24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Ribosomal RNA-processing protein 7 homolog A;
DE   AltName: Full=Gastric cancer antigen Zg14 homolog;
GN   Name=RRP7A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Nucleolar protein that is involved in ribosomal RNA (rRNA)
CC       processing. Also plays a role in primary cilia resorption, and cell
CC       cycle progression in neurogenesis and neocortex development.
CC       {ECO:0000250|UniProtKB:Q9Y3A4}.
CC   -!- SUBUNIT: Interacts with NOL6. {ECO:0000250|UniProtKB:Q9Y3A4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9Y3A4}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q9Y3A4}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome {ECO:0000250|UniProtKB:Q9Y3A4}.
CC   -!- SIMILARITY: Belongs to the RRP7 family. {ECO:0000305}.
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DR   EMBL; CR859208; CAH91393.1; -; mRNA.
DR   RefSeq; NP_001125823.1; NM_001132351.1.
DR   AlphaFoldDB; Q5RA17; -.
DR   SMR; Q5RA17; -.
DR   STRING; 9601.ENSPPYP00000013277; -.
DR   GeneID; 100172751; -.
DR   KEGG; pon:100172751; -.
DR   CTD; 27341; -.
DR   eggNOG; KOG4008; Eukaryota.
DR   InParanoid; Q5RA17; -.
DR   OrthoDB; 1607176at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0061523; P:cilium disassembly; ISS:UniProtKB.
DR   GO; GO:0042254; P:ribosome biogenesis; ISS:UniProtKB.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   CDD; cd12294; RRM_Rrp7A; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR040447; RRM_Rrp7.
DR   InterPro; IPR040446; RRP7.
DR   InterPro; IPR024326; RRP7_C.
DR   InterPro; IPR034890; Rrp7A_RRM.
DR   PANTHER; PTHR13191; PTHR13191; 1.
DR   Pfam; PF17799; RRM_Rrp7; 1.
DR   Pfam; PF12923; RRP7; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..280
FT                   /note="Ribosomal RNA-processing protein 7 homolog A"
FT                   /id="PRO_0000082010"
FT   DOMAIN          61..90
FT                   /note="RRM"
FT   MOD_RES         99
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y3A4"
SQ   SEQUENCE   280 AA;  32429 MW;  F4429E8C92BB9E7D CRC64;
     MVARRRKRAA RDPEDRIPSP LGYAAIPIKF SEKQQASHYL YVRAHSVRQG TKSTWPQKRT
     LFVLNVPPYC TEESLSRLLS SCGPLQSVEL QEKPDLADSP KESRSKFFHP KPVPGFRVGY
     VVFQKPSGVS AALALQGPLL VSTESHPVKT GIHKWISDYA DSVPDPEALR VEVDTFMEAY
     DQKIAEEEAK AKEEEGVPDE EGWVKVTRRG RRPVLPRTEA ASLRVLERER RKRTRKELLN
     FYAWQHRESK MEHLAQLRKK FEEDKQRIEL LRAQRKFRPY