RRP7_SCHPO
ID RRP7_SCHPO Reviewed; 238 AA.
AC O94683;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Ribosomal RNA-processing protein 7;
GN Name=rrp7; ORFNames=SPBC776.17;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Plays an important role in the synthesis of 18S rRNA but is
CC not required for the 5.8S and 25S pathway. Is necessary for the
CC cleavage at site A2 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus,
CC nucleolus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the RRP7 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA22890.2; -; Genomic_DNA.
DR PIR; T40688; T40688.
DR RefSeq; NP_596333.2; NM_001022254.2.
DR AlphaFoldDB; O94683; -.
DR SMR; O94683; -.
DR BioGRID; 277688; 4.
DR STRING; 4896.SPBC776.17.1; -.
DR iPTMnet; O94683; -.
DR MaxQB; O94683; -.
DR PaxDb; O94683; -.
DR PRIDE; O94683; -.
DR EnsemblFungi; SPBC776.17.1; SPBC776.17.1:pep; SPBC776.17.
DR GeneID; 2541174; -.
DR KEGG; spo:SPBC776.17; -.
DR PomBase; SPBC776.17; rrp7.
DR VEuPathDB; FungiDB:SPBC776.17; -.
DR eggNOG; KOG4008; Eukaryota.
DR HOGENOM; CLU_1180803_0_0_1; -.
DR InParanoid; O94683; -.
DR OMA; FIRLMDP; -.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:O94683; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0032545; C:CURI complex; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0034456; C:UTP-C complex; ISO:PomBase.
DR GO; GO:0000028; P:ribosomal small subunit assembly; ISO:PomBase.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR InterPro; IPR040446; RRP7.
DR InterPro; IPR024326; RRP7_C.
DR PANTHER; PTHR13191; PTHR13191; 1.
DR Pfam; PF12923; RRP7; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..238
FT /note="Ribosomal RNA-processing protein 7"
FT /id="PRO_0000374040"
SQ SEQUENCE 238 AA; 27975 MW; F26079204DED700F CRC64;
MDKLKEKGFV KLEIYLENKK RLHSIFLKED TEDVEKKSLY LINVPITTTE KILKRAISQL
GGRIVNIYPN ISGLLKSGTH LRVKLVEPAE VKQVIKAASK KTTSLPWKFT QHTGLKRYVE
SYDRQFVNPR VLAESVDSYM KRVTKKEIAE KRRLFAMKNQ PDEDGFVTVV RSGRAPVGRP
QDAERQLEKK KDTGIHKDFY RFQLREKKKK ALLDLAHKFE FDKQRIQQLK EKRQFKPY
