ID   RRS1_BOVIN              Reviewed;         365 AA.
AC   Q2KIH4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Ribosome biogenesis regulatory protein homolog;
GN   Name=RRS1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in ribosomal large subunit assembly. May regulate
CC       the localization of the 5S RNP/5S ribonucleoprotein particle to the
CC       nucleolus. {ECO:0000250|UniProtKB:Q15050}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q15050}.
CC   -!- PTM: Citrullinated by PADI4. {ECO:0000250|UniProtKB:Q9CYH6}.
CC   -!- SIMILARITY: Belongs to the RRS1 family. {ECO:0000305}.
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DR   EMBL; BC112636; AAI12637.1; -; mRNA.
DR   RefSeq; NP_001068949.1; NM_001075481.2.
DR   AlphaFoldDB; Q2KIH4; -.
DR   SMR; Q2KIH4; -.
DR   STRING; 9913.ENSBTAP00000022217; -.
DR   PaxDb; Q2KIH4; -.
DR   PRIDE; Q2KIH4; -.
DR   GeneID; 510956; -.
DR   KEGG; bta:510956; -.
DR   CTD; 23212; -.
DR   eggNOG; KOG1765; Eukaryota.
DR   InParanoid; Q2KIH4; -.
DR   OrthoDB; 1264304at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0000794; C:condensed nuclear chromosome; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0008097; F:5S rRNA binding; ISS:UniProtKB.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0007080; P:mitotic metaphase plate congression; ISS:UniProtKB.
DR   GO; GO:1902570; P:protein localization to nucleolus; ISS:UniProtKB.
DR   GO; GO:1901796; P:regulation of signal transduction by p53 class mediator; ISS:UniProtKB.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; ISS:UniProtKB.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IBA:GO_Central.
DR   InterPro; IPR007023; Ribosom_reg.
DR   PANTHER; PTHR17602; PTHR17602; 1.
DR   Pfam; PF04939; RRS1; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Citrullination; Isopeptide bond; Nucleus; Phosphoprotein;
KW   Reference proteome; Ribosome biogenesis; Ubl conjugation.
FT   CHAIN           1..365
FT                   /note="Ribosome biogenesis regulatory protein homolog"
FT                   /id="PRO_0000327745"
FT   REGION          202..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          229..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          273..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        288..305
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15050"
FT   MOD_RES         5
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15050"
FT   MOD_RES         273
FT                   /note="Citrulline"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CYH6"
FT   CROSSLNK        154
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q15050"
FT   CROSSLNK        226
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q15050"
FT   CROSSLNK        266
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q15050"
SQ   SEQUENCE   365 AA;  41427 MW;  AB244661B1017F82 CRC64;
     MEGQSVEELL AKAERDEAEK LQRITVLKEL ELEFDLGNLL ASDRNPPTGL RHAGPTQEAE
     LRALARDNTQ LLINQLWQLP TERVEEALVA RLPEPSTRLP REKPVPRPRP LTRWQQFARL
     KGIRPKKKTN LVWDEVSGRW RRRWGYQRAR DDTKEWLIEV PGNADPMEDQ FAKRIQAKKE
     RVAKNELNRL RNLARAHKMQ LPSAAGMHPT GHQSKEELGR AMQVAKVSTA SVGRFQERLP
     KEKAPRGSGK KRKFQPLFGD FAAERKSQLE MLRVMNSKKP QMDITRATNK QMREEDQEEA
     AKRRKMSQKG KRKGGRQGPG SKRKGGTPSQ GGKRKGGLGG KMNSGPPGLS GKRKGGQHQG
     GKRRK