RRS1_DICDI
ID RRS1_DICDI Reviewed; 317 AA.
AC Q869Q2; Q555I7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Ribosome biogenesis regulatory protein homolog;
GN Name=rrs1; ORFNames=DDB_G0274521;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Involved in ribosomal large subunit assembly.
CC {ECO:0000250|UniProtKB:Q15050}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q15050}.
CC -!- SIMILARITY: Belongs to the RRS1 family. {ECO:0000305}.
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DR EMBL; AAFI02000012; EAL70153.1; -; Genomic_DNA.
DR RefSeq; XP_644082.1; XM_638990.1.
DR AlphaFoldDB; Q869Q2; -.
DR SMR; Q869Q2; -.
DR STRING; 44689.DDB0304994; -.
DR PaxDb; Q869Q2; -.
DR EnsemblProtists; EAL70153; EAL70153; DDB_G0274521.
DR GeneID; 8619511; -.
DR KEGG; ddi:DDB_G0274521; -.
DR dictyBase; DDB_G0274521; rrs1.
DR eggNOG; KOG1765; Eukaryota.
DR HOGENOM; CLU_065163_1_0_1; -.
DR InParanoid; Q869Q2; -.
DR OMA; LLINEIW; -.
DR PhylomeDB; Q869Q2; -.
DR PRO; PR:Q869Q2; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR GO; GO:0030687; C:preribosome, large subunit precursor; ISS:dictyBase.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000027; P:ribosomal large subunit assembly; ISS:UniProtKB.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; IBA:GO_Central.
DR GO; GO:0042254; P:ribosome biogenesis; ISS:dictyBase.
DR InterPro; IPR007023; Ribosom_reg.
DR PANTHER; PTHR17602; PTHR17602; 1.
DR Pfam; PF04939; RRS1; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribosome biogenesis.
FT CHAIN 1..317
FT /note="Ribosome biogenesis regulatory protein homolog"
FT /id="PRO_0000327747"
FT REGION 161..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..252
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..310
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 317 AA; 36493 MW; 31A8949CFB311215 CRC64;
MTEEIVNASD ILTKKLDGHL IDGEDTLLYD LGNLTAFDHS SLNKTEYKSN PNEYINKLSR
DNVQLLISRL FQLPIKEIEE GSLALLPRCT TPIPRERSLP TSKPKTRWEA FAEIKGIKKK
KKSSMEWDKE HEEYRPTFGY KKANDVANDW AMLARPDDKV GEDPFKKLED EKNDRVSKQK
KREQRNFDEA SMRQMSNVGK TLSFDKEHRG QIKSDMEKVF DVAKLSTASL GKFDKRVENE
KDAPKRGKKK LAGLGAGDVA QESENNSKLI DRMFKKENVL NVDKATRQFV KAEERENYSK
KRSSGGKDNK SQKRFKK
