ID   RRS1_RAT                Reviewed;         365 AA.
AC   A1A5P2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Ribosome biogenesis regulatory protein homolog;
GN   Name=Rrs1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in ribosomal large subunit assembly. May regulate
CC       the localization of the 5S RNP/5S ribonucleoprotein particle to the
CC       nucleolus. {ECO:0000250|UniProtKB:Q15050}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q15050}.
CC   -!- PTM: Citrullinated by PADI4. {ECO:0000250|UniProtKB:Q9CYH6}.
CC   -!- SIMILARITY: Belongs to the RRS1 family. {ECO:0000305}.
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DR   EMBL; BC128746; AAI28747.1; -; mRNA.
DR   RefSeq; NP_001073167.1; NM_001079699.1.
DR   AlphaFoldDB; A1A5P2; -.
DR   SMR; A1A5P2; -.
DR   STRING; 10116.ENSRNOP00000009482; -.
DR   iPTMnet; A1A5P2; -.
DR   PhosphoSitePlus; A1A5P2; -.
DR   PaxDb; A1A5P2; -.
DR   PeptideAtlas; A1A5P2; -.
DR   PRIDE; A1A5P2; -.
DR   Ensembl; ENSRNOT00000009482; ENSRNOP00000009482; ENSRNOG00000007240.
DR   GeneID; 297784; -.
DR   KEGG; rno:297784; -.
DR   UCSC; RGD:1311403; rat.
DR   CTD; 23212; -.
DR   RGD; 1311403; Rrs1.
DR   eggNOG; KOG1765; Eukaryota.
DR   GeneTree; ENSGT00390000005213; -.
DR   HOGENOM; CLU_065163_1_0_1; -.
DR   InParanoid; A1A5P2; -.
DR   OMA; LLINEIW; -.
DR   OrthoDB; 1264304at2759; -.
DR   PhylomeDB; A1A5P2; -.
DR   TreeFam; TF313067; -.
DR   PRO; PR:A1A5P2; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000007240; Expressed in thymus and 20 other tissues.
DR   Genevisible; A1A5P2; RN.
DR   GO; GO:0000794; C:condensed nuclear chromosome; ISO:RGD.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
DR   GO; GO:0005730; C:nucleolus; ISO:RGD.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0008097; F:5S rRNA binding; ISS:UniProtKB.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISO:RGD.
DR   GO; GO:0007080; P:mitotic metaphase plate congression; ISO:RGD.
DR   GO; GO:1902570; P:protein localization to nucleolus; ISS:UniProtKB.
DR   GO; GO:1901796; P:regulation of signal transduction by p53 class mediator; ISS:UniProtKB.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; ISS:UniProtKB.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; ISO:RGD.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IBA:GO_Central.
DR   InterPro; IPR007023; Ribosom_reg.
DR   PANTHER; PTHR17602; PTHR17602; 1.
DR   Pfam; PF04939; RRS1; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Citrullination; Isopeptide bond; Nucleus; Phosphoprotein;
KW   Reference proteome; Ribosome biogenesis; Ubl conjugation.
FT   CHAIN           1..365
FT                   /note="Ribosome biogenesis regulatory protein homolog"
FT                   /id="PRO_0000327746"
FT   REGION          200..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          272..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        288..305
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15050"
FT   MOD_RES         5
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15050"
FT   MOD_RES         273
FT                   /note="Citrulline"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CYH6"
FT   CROSSLNK        154
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q15050"
FT   CROSSLNK        226
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q15050"
FT   CROSSLNK        266
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q15050"
SQ   SEQUENCE   365 AA;  41537 MW;  A4D78481B81899A1 CRC64;
     MEGQSVEELL AKAKQEEAEK LQRITVHKEL ELEFDLGNLL ASDRNPPTVL RQAGPSPEAE
     LRALARDNTQ LLVNQLWQLP TERVEEAVVA RLPEPATRLP REKPLPRPRP LTRWQQFARL
     KGIRPKKKTN LVWDEVSGQW RRRWGYKRAR DDTKEWLIEV PGSADPMEDQ FAKRIRAKKE
     RVAKNELNRL RNLARAHKMQ MPSSAGLHPT GHQSKEELGR AMQVAKVSTA SVGRFQERLP
     KEKAPRGSGK KRKFQPLFGD FAAEKKNQLE LLRVMNSKKP QLDVTRATNK QMREEDQEEA
     AKRRKMSQKG KKKGGRQGPS GRRKGGPPSQ GEKRKGVLGG KKHSRPPALG GKKKGVPHHG
     GKRRK