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RRS1_SCHPO
ID   RRS1_SCHPO              Reviewed;         166 AA.
AC   O59678;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Ribosome biogenesis regulatory protein homolog;
GN   ORFNames=SPBC29A3.16;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   INTERACTION WITH SAD1, AND SUBCELLULAR LOCATION.
RX   PubMed=14655046; DOI=10.1007/s00438-003-0938-8;
RA   Miki F., Kurabayashi A., Tange Y., Okazaki K., Shimanuki M., Niwa O.;
RT   "Two-hybrid search for proteins that interact with Sad1 and Kms1, two
RT   membrane-bound components of the spindle pole body in fission yeast.";
RL   Mol. Genet. Genomics 270:449-461(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34 AND SER-64, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: Involved in ribosomal large subunit assembly.
CC       {ECO:0000250|UniProtKB:Q08746}.
CC   -!- SUBUNIT: Interacts with sad1. {ECO:0000269|PubMed:14655046}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:14655046}.
CC   -!- SIMILARITY: Belongs to the RRS1 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA18393.1; -; Genomic_DNA.
DR   PIR; T40087; T40087.
DR   RefSeq; NP_595844.1; NM_001021748.2.
DR   AlphaFoldDB; O59678; -.
DR   SMR; O59678; -.
DR   BioGRID; 276854; 16.
DR   IntAct; O59678; 3.
DR   STRING; 4896.SPBC29A3.16.1; -.
DR   iPTMnet; O59678; -.
DR   MaxQB; O59678; -.
DR   PaxDb; O59678; -.
DR   PRIDE; O59678; -.
DR   EnsemblFungi; SPBC29A3.16.1; SPBC29A3.16.1:pep; SPBC29A3.16.
DR   GeneID; 2540324; -.
DR   KEGG; spo:SPBC29A3.16; -.
DR   PomBase; SPBC29A3.16; -.
DR   VEuPathDB; FungiDB:SPBC29A3.16; -.
DR   eggNOG; KOG1765; Eukaryota.
DR   HOGENOM; CLU_065163_2_1_1; -.
DR   InParanoid; O59678; -.
DR   OMA; KMVYDEA; -.
DR   PhylomeDB; O59678; -.
DR   PRO; PR:O59678; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005730; C:nucleolus; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IMP:PomBase.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IBA:GO_Central.
DR   InterPro; IPR007023; Ribosom_reg.
DR   PANTHER; PTHR17602; PTHR17602; 1.
DR   Pfam; PF04939; RRS1; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..166
FT                   /note="Ribosome biogenesis regulatory protein homolog"
FT                   /id="PRO_0000185378"
FT   REGION          144..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         34
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         64
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   166 AA;  19044 MW;  B6BA8CA51F942B69 CRC64;
     MSAQIENSIP LDFDLGNMAA FDISPLDETK LSGSEKESFL FSLSRDNVQQ LVNKMISLPK
     ERTSDGVLLQ LPETVTPLPR AKPLPKPKPE TKWQRFARIK GIAPKKREGR LVFDEASGEW
     VPKWGYKGKN KELETQWLVE EGEKEKKLTS KQVRNTSKKI KRSRRH
 
 
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