RRS1_YEAST
ID RRS1_YEAST Reviewed; 203 AA.
AC Q08746; D6W2Z3;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Regulator of ribosome biosynthesis;
GN Name=RRS1; OrderedLocusNames=YOR294W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=9153758;
RX DOI=10.1002/(sici)1097-0061(199704)13:5<479::aid-yea104>3.0.co;2-g;
RA Poirey R., Cziepluch C., Tobiasch E., Pujol A., Kordes E., Jauniaux J.-C.;
RT "Sequence and analysis of a 36.2 kb fragment from the right arm of yeast
RT chromosome XV reveals 19 open reading frames including SNF2 (5' end), CPA1,
RT SLY41, a putative transport ATPase, a putative ribosomal protein and an
RT SNF2 homologue.";
RL Yeast 13:479-482(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=10688653; DOI=10.1128/mcb.20.6.2066-2074.2000;
RA Tsuno A., Miyoshi K., Tsujii R., Miyakawa T., Mizuta K.;
RT "RRS1, a conserved essential gene, encodes a novel regulatory protein
RT required for ribosome biogenesis in Saccharomyces cerevisiae.";
RL Mol. Cell. Biol. 20:2066-2074(2000).
CC -!- FUNCTION: Required for ribosome biogenesis.
CC {ECO:0000269|PubMed:10688653}.
CC -!- INTERACTION:
CC Q08746; P47069: MPS3; NbExp=4; IntAct=EBI-16026, EBI-25811;
CC Q08746; P36160: RPF2; NbExp=5; IntAct=EBI-16026, EBI-15881;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10688653}.
CC -!- DISRUPTION PHENOTYPE: Depletion causes defects in processing of
CC pre- rRNA and assembly of ribosomal subunits.
CC {ECO:0000269|PubMed:10688653}.
CC -!- SIMILARITY: Belongs to the RRS1 family. {ECO:0000305}.
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DR EMBL; Z75202; CAA99522.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA11059.1; -; Genomic_DNA.
DR PIR; S67198; S67198.
DR RefSeq; NP_014937.1; NM_001183713.1.
DR PDB; 3JCT; EM; 3.08 A; w=1-203.
DR PDB; 5A53; X-ray; 2.40 A; A=9-73, B=85-106.
DR PDB; 5WXL; X-ray; 1.90 A; B/D=20-121.
DR PDB; 6FT6; EM; 3.90 A; w=1-203.
DR PDB; 6M62; EM; 3.20 A; w=1-203.
DR PDB; 7BT6; EM; 3.12 A; w=1-203.
DR PDB; 7BTB; EM; 3.22 A; w=1-203.
DR PDB; 7OH3; EM; 3.40 A; w=1-203.
DR PDB; 7OHQ; EM; 3.10 A; w=1-203.
DR PDB; 7OHT; EM; 4.70 A; w=1-203.
DR PDBsum; 3JCT; -.
DR PDBsum; 5A53; -.
DR PDBsum; 5WXL; -.
DR PDBsum; 6FT6; -.
DR PDBsum; 6M62; -.
DR PDBsum; 7BT6; -.
DR PDBsum; 7BTB; -.
DR PDBsum; 7OH3; -.
DR PDBsum; 7OHQ; -.
DR PDBsum; 7OHT; -.
DR AlphaFoldDB; Q08746; -.
DR SMR; Q08746; -.
DR BioGRID; 34682; 234.
DR DIP; DIP-4081N; -.
DR IntAct; Q08746; 46.
DR MINT; Q08746; -.
DR STRING; 4932.YOR294W; -.
DR MaxQB; Q08746; -.
DR PaxDb; Q08746; -.
DR PRIDE; Q08746; -.
DR EnsemblFungi; YOR294W_mRNA; YOR294W; YOR294W.
DR GeneID; 854469; -.
DR KEGG; sce:YOR294W; -.
DR SGD; S000005820; RRS1.
DR VEuPathDB; FungiDB:YOR294W; -.
DR eggNOG; KOG1765; Eukaryota.
DR GeneTree; ENSGT00390000005213; -.
DR HOGENOM; CLU_065163_2_1_1; -.
DR InParanoid; Q08746; -.
DR OMA; KMVYDEA; -.
DR BioCyc; YEAST:G3O-33779-MON; -.
DR PRO; PR:Q08746; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q08746; protein.
DR GO; GO:0034399; C:nuclear periphery; IDA:SGD.
DR GO; GO:0005730; C:nucleolus; IDA:SGD.
DR GO; GO:0005654; C:nucleoplasm; IDA:SGD.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IDA:SGD.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IMP:SGD.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; IMP:SGD.
DR InterPro; IPR007023; Ribosom_reg.
DR PANTHER; PTHR17602; PTHR17602; 1.
DR Pfam; PF04939; RRS1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Nucleus; Reference proteome; Ribosome biogenesis.
FT CHAIN 1..203
FT /note="Regulator of ribosome biosynthesis"
FT /id="PRO_0000185379"
FT REGION 184..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 20..22
FT /evidence="ECO:0007829|PDB:5WXL"
FT HELIX 23..25
FT /evidence="ECO:0007829|PDB:5WXL"
FT STRAND 27..30
FT /evidence="ECO:0007829|PDB:5WXL"
FT HELIX 36..39
FT /evidence="ECO:0007829|PDB:5WXL"
FT HELIX 46..65
FT /evidence="ECO:0007829|PDB:5WXL"
FT STRAND 70..72
FT /evidence="ECO:0007829|PDB:5WXL"
FT STRAND 88..91
FT /evidence="ECO:0007829|PDB:5WXL"
SQ SEQUENCE 203 AA; 22963 MW; 7DFF6C51DDD2ADD6 CRC64;
MSAEDYKNLP VTVEKPIPVV YDLGNLAAFD SNVLDKNDLD SSNARREEKI KSLTRDNVQL
LINQLLSLPM KTTTESVGGT GGQSSVMTLL QLPDPTTDLP REKPLPKAKA MTKWEKFAAK
KGIKPKERAG KMIYDEASGE WVPKWGYKGA NKKLDDQWLV EVDDKVKGTD NELIDPRTLN
RAERKRLVKK NEKQQRRNMK NAL
