RRT14_YEAST
ID RRT14_YEAST Reviewed; 206 AA.
AC P40470; D6VVG0;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Regulator of rDNA transcription protein 14;
GN Name=RRT14; OrderedLocusNames=YIL127C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169870;
RA Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL Nature 387:84-87(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP FUNCTION.
RX PubMed=16544271; DOI=10.1002/yea.1353;
RA Wade C.H., Umbarger M.A., McAlear M.A.;
RT "The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains
RT over 200 genes.";
RL Yeast 23:293-306(2006).
RN [7]
RP FUNCTION.
RX PubMed=19270272; DOI=10.1534/genetics.108.100313;
RA Hontz R.D., Niederer R.O., Johnson J.M., Smith J.S.;
RT "Genetic identification of factors that modulate ribosomal DNA
RT transcription in Saccharomyces cerevisiae.";
RL Genetics 182:105-119(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197; SER-202 AND SER-203, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- FUNCTION: Involved in ribosome biogenesis, probably through modulation
CC of rDNA transcription. {ECO:0000269|PubMed:16544271,
CC ECO:0000269|PubMed:19270272}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 3670 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the RRT14 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z46833; CAA86865.1; -; Genomic_DNA.
DR EMBL; AY557768; AAS56094.1; -; Genomic_DNA.
DR EMBL; BK006942; DAA08426.1; -; Genomic_DNA.
DR PIR; S49882; S49882.
DR RefSeq; NP_012139.1; NM_001179475.1.
DR PDB; 5WLC; EM; 3.80 A; SV=1-206.
DR PDB; 6LQP; EM; 3.20 A; RW=1-206.
DR PDB; 6LQS; EM; 3.80 A; RW=1-206.
DR PDB; 6LQU; EM; 3.70 A; RW=1-206.
DR PDB; 6ZQA; EM; 4.40 A; JQ=1-206.
DR PDB; 6ZQB; EM; 3.90 A; JQ=1-206.
DR PDB; 6ZQC; EM; 3.80 A; JQ=1-206.
DR PDB; 7AJT; EM; 4.60 A; JQ=1-206.
DR PDB; 7D4I; EM; 4.00 A; RW=1-206.
DR PDB; 7D5S; EM; 4.60 A; RW=1-206.
DR PDBsum; 5WLC; -.
DR PDBsum; 6LQP; -.
DR PDBsum; 6LQS; -.
DR PDBsum; 6LQU; -.
DR PDBsum; 6ZQA; -.
DR PDBsum; 6ZQB; -.
DR PDBsum; 6ZQC; -.
DR PDBsum; 7AJT; -.
DR PDBsum; 7D4I; -.
DR PDBsum; 7D5S; -.
DR AlphaFoldDB; P40470; -.
DR SMR; P40470; -.
DR BioGRID; 34864; 65.
DR IntAct; P40470; 6.
DR MINT; P40470; -.
DR STRING; 4932.YIL127C; -.
DR iPTMnet; P40470; -.
DR MaxQB; P40470; -.
DR PaxDb; P40470; -.
DR PRIDE; P40470; -.
DR EnsemblFungi; YIL127C_mRNA; YIL127C; YIL127C.
DR GeneID; 854679; -.
DR KEGG; sce:YIL127C; -.
DR SGD; S000001389; RRT14.
DR VEuPathDB; FungiDB:YIL127C; -.
DR eggNOG; ENOG502S1G1; Eukaryota.
DR HOGENOM; CLU_095038_0_0_1; -.
DR InParanoid; P40470; -.
DR OMA; IKYNHIK; -.
DR BioCyc; YEAST:G3O-31378-MON; -.
DR PRO; PR:P40470; -.
DR Proteomes; UP000002311; Chromosome IX.
DR RNAct; P40470; protein.
DR GO; GO:0005730; C:nucleolus; HDA:SGD.
DR InterPro; IPR031404; Rrt14.
DR Pfam; PF17075; RRT14; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..206
FT /note="Regulator of rDNA transcription protein 14"
FT /id="PRO_0000202961"
FT REGION 178..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 197
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19779198"
FT MOD_RES 202
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19779198"
FT MOD_RES 203
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19779198"
SQ SEQUENCE 206 AA; 23845 MW; 4E51B11216F7ECB8 CRC64;
MSSSLSQTSK YQATSVVNGL LSNLLPGVPK IRANNGKTSV NNGSKAQLID RNLKKRVQLQ
NRDVHKIKKK CKLVKKKKVK KHKLDKEQLE QLAKHQVLKK HQHEGTLTDH ERKYLNKLIK
RNSQNLRSWD LEEEVRDELE DIQQSILKDT VSTANTDRSK RRRFKRKQFK EDIKESDFVK
DHRYPGLTPG LAPVGLSDEE DSSEED
