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RRT1_YEAST
ID   RRT1_YEAST              Reviewed;         103 AA.
AC   P38192; A0A1S0T031;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Regulator of rDNA transcription protein 1;
GN   Name=RRT1; OrderedLocusNames=YBL048W; ORFNames=YBL0519;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8154187; DOI=10.1002/yea.320091210;
RA   Scherens B., el Bakkoury M., Vierendeels F., Dubois E., Messenguy F.;
RT   "Sequencing and functional analysis of a 32,560 bp segment on the left arm
RT   of yeast chromosome II. Identification of 26 open reading frames, including
RT   the KIP1 and SEC17 genes.";
RL   Yeast 9:1355-1371(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA   Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA   Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA   Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA   Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA   Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA   Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA   Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA   Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA   Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA   Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA   Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA   Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA   Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA   Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA   Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA   Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA   Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA   Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA   Mewes H.-W., Kleine K.;
RT   "Complete DNA sequence of yeast chromosome II.";
RL   EMBO J. 13:5795-5809(1994).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [5]
RP   INDUCTION.
RX   PubMed=10884426; DOI=10.1073/pnas.97.14.7957;
RA   Lyons T.J., Gasch A.P., Gaither L.A., Botstein D., Brown P.O., Eide D.J.;
RT   "Genome-wide characterization of the Zap1p zinc-responsive regulon in
RT   yeast.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:7957-7962(2000).
RN   [6]
RP   INDUCTION.
RX   PubMed=14561723; DOI=10.1093/jb/mvg155;
RA   Sakaki K., Tashiro K., Kuhara S., Mihara K.;
RT   "Response of genes associated with mitochondrial function to mild heat
RT   stress in yeast Saccharomyces cerevisiae.";
RL   J. Biochem. 134:373-384(2003).
RN   [7]
RP   GENE NAME.
RX   PubMed=19270272; DOI=10.1534/genetics.108.100313;
RA   Hontz R.D., Niederer R.O., Johnson J.M., Smith J.S.;
RT   "Genetic identification of factors that modulate ribosomal DNA
RT   transcription in Saccharomyces cerevisiae.";
RL   Genetics 182:105-119(2009).
CC   -!- FUNCTION: Identified in a screen for mutants with decreased levels of
CC       rDNA transcription.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: By the zinc-responsive transcription factor ZAP1 in response
CC       to zinc deficiency and by mild heat stress.
CC       {ECO:0000269|PubMed:10884426, ECO:0000269|PubMed:14561723}.
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DR   EMBL; Z23261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; Z35809; CAA84868.1; -; Genomic_DNA.
DR   EMBL; AY693312; AAT93331.1; -; Genomic_DNA.
DR   EMBL; BK006936; DAA80264.1; -; Genomic_DNA.
DR   PIR; S45783; S45783.
DR   AlphaFoldDB; P38192; -.
DR   IntAct; P38192; 1.
DR   MINT; P38192; -.
DR   STRING; 4932.YBL048W; -.
DR   PaxDb; P38192; -.
DR   PRIDE; P38192; -.
DR   EnsemblFungi; YBL048W_mRNA; YBL048W; YBL048W.
DR   SGD; S000000144; RRT1.
DR   HOGENOM; CLU_2265821_0_0_1; -.
DR   ChiTaRS; RRT1; yeast.
DR   PRO; PR:P38192; -.
DR   Proteomes; UP000002311; Chromosome II.
DR   RNAct; P38192; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..103
FT                   /note="Regulator of rDNA transcription protein 1"
FT                   /id="PRO_0000202456"
FT   TRANSMEM        9..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   103 AA;  12447 MW;  43264FBB6BE4A0C3 CRC64;
     MILFKNLVFL PSILIGYISI RVSLLVWVNW VLVWSSCFQV AFIFSLWYFI LSIYTFFYSK
     KIKQIISYEP SYFVFSYRAI DLCPERVLLY FFCIFNNVVF PML
 
 
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