ID   RRT5_KLULA              Reviewed;         425 AA.
AC   Q6CQM2;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Regulator of rDNA transcription protein 5;
GN   Name=RRT5; OrderedLocusNames=KLLA0D16049g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: May be involved in the modulation of rDNA transcription.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRT5 family. {ECO:0000305}.
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DR   EMBL; CR382124; CAH00863.1; -; Genomic_DNA.
DR   RefSeq; XP_453767.1; XM_453767.1.
DR   AlphaFoldDB; Q6CQM2; -.
DR   STRING; 28985.XP_453767.1; -.
DR   PRIDE; Q6CQM2; -.
DR   EnsemblFungi; CAH00863; CAH00863; KLLA0_D16049g.
DR   GeneID; 2893300; -.
DR   KEGG; kla:KLLA0_D16049g; -.
DR   eggNOG; ENOG502RZDM; Eukaryota.
DR   HOGENOM; CLU_042558_0_0_1; -.
DR   InParanoid; Q6CQM2; -.
DR   OMA; PENEHTQ; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   CDD; cd12409; RRM1_RRT5; 1.
DR   CDD; cd12410; RRM2_RRT5; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR034244; Rrt5_RRM1.
DR   InterPro; IPR034247; Rrt5_RRM2.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; RNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..425
FT                   /note="Regulator of rDNA transcription protein 5"
FT                   /id="PRO_0000404358"
FT   DOMAIN          5..88
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          231..314
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          109..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          140..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          329..425
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..182
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..425
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   425 AA;  46230 MW;  AE8A409541A87082 CRC64;
     MSSHARVYIS NLSFEASENQ LYEYLQDYNV ISVLIPSQTV RGLKNKAVRP FGIAYAEFSN
     EEDANKVIQE LNGKLFMERH LNLRMHIPID SNKVQIVRKS SVAVVASSTA GADPSASSDT
     PAEAPEVASA LEQQPLVKQL KSRKHRLTPF RRKKREEPAV EADIPEASTE NVQETGNNET
     EVSEAVAGAA DANAGANADA NPIVTVDPVN SESSDVGNVT TVITEKPVSE TIAFIGFIPR
     NTTDNQLREY FKGFDPQEIV VFKNRTYRRG FTFHRHFTAA LVTFPDAFRL NDAKQFATQE
     KFRGKQINVK NAFIEKIEEV QRALEKKAGA NTNGESAEGN NEIPADAGVT GDEPDTANAV
     AAIPIEGNPQ PQADGNDGAV VEPEANAEPL IDQEDGVTAS QDNPLLNSNA ESQLESQQPV
     EQVAA