ID   RRT5_LACTC              Reviewed;         291 AA.
AC   C5DHJ1;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Regulator of rDNA transcription protein 5;
GN   Name=RRT5; OrderedLocusNames=KLTH0E04730g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: May be involved in the modulation of rDNA transcription.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRT5 family. {ECO:0000305}.
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DR   EMBL; CU928169; CAR23252.1; -; Genomic_DNA.
DR   RefSeq; XP_002553689.1; XM_002553643.1.
DR   AlphaFoldDB; C5DHJ1; -.
DR   SMR; C5DHJ1; -.
DR   STRING; 559295.C5DHJ1; -.
DR   EnsemblFungi; CAR23252; CAR23252; KLTH0E04730g.
DR   GeneID; 8291838; -.
DR   KEGG; lth:KLTH0E04730g; -.
DR   eggNOG; ENOG502RZDM; Eukaryota.
DR   HOGENOM; CLU_042558_0_0_1; -.
DR   InParanoid; C5DHJ1; -.
DR   OMA; IWIFRTR; -.
DR   OrthoDB; 1442049at2759; -.
DR   Proteomes; UP000002036; Chromosome E.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   CDD; cd12409; RRM1_RRT5; 1.
DR   CDD; cd12410; RRM2_RRT5; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR034244; Rrt5_RRM1.
DR   InterPro; IPR034247; Rrt5_RRM2.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; RNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..291
FT                   /note="Regulator of rDNA transcription protein 5"
FT                   /id="PRO_0000404359"
FT   DOMAIN          21..104
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          152..235
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          109..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          271..291
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..124
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   291 AA;  32649 MW;  81890C7971637E25 CRC64;
     MSPTQPNPAA ALSGSAEPQT KRIYISNLDF STTEEELEQF LQEFRVVSVL IPSQTVRGFR
     NSTVRPLGIG YADFASAADA LQAVENLNGK QLRERTLKIK MYVPYSPRAR AERRKEKRKV
     PAPQAEENPD AAPQDAQQPQ PPAPAEEPTS KDTVYCAYLP SKVTDVELRE FFADYQPQDI
     YVYRTNGSRR KVYFHRRFTA ALVTLGGEAE LANAIETLGT RRLMGKKITL RPARLSKVEE
     VQHAAARKLE LEQIQQQTRQ IAEHAMAMEE HRQQEAEIPA AETPDDVAAT A