RRT5_YEAST
ID RRT5_YEAST Reviewed; 289 AA.
AC P43607; D6VTR3;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Regulator of rDNA transcription protein 5;
GN Name=RRT5; OrderedLocusNames=YFR032C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7670463; DOI=10.1038/ng0795-261;
RA Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S.,
RA Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H.,
RA Eki T.;
RT "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces
RT cerevisiae.";
RL Nat. Genet. 10:261-268(1995).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204511 / S288c / AB972;
RX PubMed=8686381;
RX DOI=10.1002/(sici)1097-0061(199602)12:2<177::aid-yea896>3.0.co;2-a;
RA Eki T., Naitou M., Hagiwara H., Abe M., Ozawa M., Sasanuma S., Sasanuma M.,
RA Tsuchiya Y., Shibata T., Watanabe K., Ono A., Yamazaki M., Tashiro H.,
RA Hanaoka F., Murakami Y.;
RT "Fifteen open reading frames in a 30.8 kb region of the right arm of
RT chromosome VI from Saccharomyces cerevisiae.";
RL Yeast 12:177-190(1996).
RN [4]
RP INDUCTION.
RX PubMed=9364751;
RX DOI=10.1002/(sici)1097-0061(199710)13:13<1275::aid-yea172>3.0.co;2-7;
RA Naitou M., Hagiwara H., Hanaoka F., Eki T., Murakami Y.;
RT "Expression profiles of transcripts from 126 open reading frames in the
RT entire chromosome VI of Saccharomyces cerevisiae by systematic northern
RT analyses.";
RL Yeast 13:1275-1290(1997).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP FUNCTION.
RX PubMed=19270272; DOI=10.1534/genetics.108.100313;
RA Hontz R.D., Niederer R.O., Johnson J.M., Smith J.S.;
RT "Genetic identification of factors that modulate ribosomal DNA
RT transcription in Saccharomyces cerevisiae.";
RL Genetics 182:105-119(2009).
CC -!- FUNCTION: May be involved in the modulation of rDNA transcription.
CC {ECO:0000269|PubMed:19270272}.
CC -!- INDUCTION: Specifically expressed during sporulation.
CC {ECO:0000269|PubMed:9364751}.
CC -!- MISCELLANEOUS: Present with 51100 molecules/cell in log phase SD
CC medium. {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the RRT5 family. {ECO:0000305}.
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DR EMBL; D50617; BAA09271.1; -; Genomic_DNA.
DR EMBL; BK006940; DAA12473.1; -; Genomic_DNA.
DR PIR; S56287; S56287.
DR RefSeq; NP_116689.1; NM_001179997.1.
DR AlphaFoldDB; P43607; -.
DR BioGRID; 31188; 29.
DR DIP; DIP-1808N; -.
DR IntAct; P43607; 1.
DR MINT; P43607; -.
DR STRING; 4932.YFR032C; -.
DR PaxDb; P43607; -.
DR EnsemblFungi; YFR032C_mRNA; YFR032C; YFR032C.
DR GeneID; 850591; -.
DR KEGG; sce:YFR032C; -.
DR SGD; S000001928; RRT5.
DR VEuPathDB; FungiDB:YFR032C; -.
DR eggNOG; ENOG502RZDM; Eukaryota.
DR HOGENOM; CLU_042558_0_0_1; -.
DR InParanoid; P43607; -.
DR OMA; IWIFRTR; -.
DR BioCyc; YEAST:G3O-30480-MON; -.
DR PRO; PR:P43607; -.
DR Proteomes; UP000002311; Chromosome VI.
DR RNAct; P43607; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005628; C:prospore membrane; HDA:SGD.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR CDD; cd12409; RRM1_RRT5; 1.
DR CDD; cd12410; RRM2_RRT5; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034244; Rrt5_RRM1.
DR InterPro; IPR034247; Rrt5_RRM2.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 1: Evidence at protein level;
KW Reference proteome; RNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..289
FT /note="Regulator of rDNA transcription protein 5"
FT /id="PRO_0000082029"
FT DOMAIN 18..105
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 235..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 289 AA; 31865 MW; 24BC54340793F3A1 CRC64;
MTEQVNNDTT SDTTTTITTV YISNLPFTAS ERDLHAFLNN YGASSVLIPT QTVRRFSKRH
NSNPRKPLGI AFAQFANNTL ALKAIQDLNG TVFQNQKLFL KLHVPYEADS TPDTDVKKPK
EKNKVKKTPE TAADTVYCHD LPDDITDSEI RELFQLYSPQ EIWIYRSKVY RRKCIPFAPH
QITAALVTLQ SETPIGDICD SVAKTATLRG KSIIVKPAYV SKIQEIKQLV KDNLTNARDP
PPAALAEPAP APAPVEPAEQ VQEGQDNAET NDVPPPPASS SDRPTVAAT
