RRT6_YEAST
ID RRT6_YEAST Reviewed; 311 AA.
AC P53117; D6VU03;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Regulator of rDNA transcription protein 6;
GN Name=RRT6; OrderedLocusNames=YGL146C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=9046099;
RX DOI=10.1002/(sici)1097-0061(199702)13:2<177::aid-yea62>3.0.co;2-2;
RA Voet M., Defoor E., Verhasselt P., Riles L., Robben J., Volckaert G.;
RT "The sequence of a nearly unclonable 22.8 kb segment on the left arm
RT chromosome VII from Saccharomyces cerevisiae reveals ARO2, RPL9A, TIP1,
RT MRF1 genes and six new open reading frames.";
RL Yeast 13:177-182(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP FUNCTION.
RX PubMed=19270272; DOI=10.1534/genetics.108.100313;
RA Hontz R.D., Niederer R.O., Johnson J.M., Smith J.S.;
RT "Genetic identification of factors that modulate ribosomal DNA
RT transcription in Saccharomyces cerevisiae.";
RL Genetics 182:105-119(2009).
CC -!- FUNCTION: May be involved in the modulation of rDNA transcription.
CC {ECO:0000269|PubMed:19270272}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; X99960; CAA68216.1; -; Genomic_DNA.
DR EMBL; Z72668; CAA96858.1; -; Genomic_DNA.
DR EMBL; AY558502; AAS56828.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA07964.1; -; Genomic_DNA.
DR PIR; S64160; S64160.
DR RefSeq; NP_011369.1; NM_001181011.1.
DR AlphaFoldDB; P53117; -.
DR SMR; P53117; -.
DR BioGRID; 33106; 50.
DR DIP; DIP-6371N; -.
DR IntAct; P53117; 2.
DR STRING; 4932.YGL146C; -.
DR PaxDb; P53117; -.
DR PRIDE; P53117; -.
DR EnsemblFungi; YGL146C_mRNA; YGL146C; YGL146C.
DR GeneID; 852731; -.
DR KEGG; sce:YGL146C; -.
DR SGD; S000003114; RRT6.
DR VEuPathDB; FungiDB:YGL146C; -.
DR eggNOG; ENOG502S8MW; Eukaryota.
DR HOGENOM; CLU_1116284_0_0_1; -.
DR InParanoid; P53117; -.
DR OMA; FEFCFQN; -.
DR BioCyc; YEAST:G3O-30640-MON; -.
DR PRO; PR:P53117; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53117; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; NAS:SGD.
DR InterPro; IPR009038; GOLD_dom.
DR Pfam; PF01105; EMP24_GP25L; 1.
PE 4: Predicted;
KW Membrane; Reference proteome; Transcription; Transcription regulation;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Regulator of rDNA transcription protein 6"
FT /id="PRO_0000202734"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 311 AA; 34706 MW; 1224CD9C637D8EAF CRC64;
MEKASLNIAQ TKEIPLTDRR MGLRGWKACS RPHLLGRILL FMSILFITSA ELSSDVSSRE
VYMPIFNNKL SFKVPPIKRS LLLGAALYED FEYSSNNSAS DGAFCTVFNA GMNDASREVV
FEIHVMDVLQ EETDSSRFGG TSHERGRQSL GFSVFNNKNG DLLRSKKNLA SGTSVIEVNP
GNCNEFLICF INLVYDGSWS SIDTEKSVTI KMTYNDKLDP DMLLHLVNQM TPQVVKALNT
VSDGLFQIVS DTTLLQMESD RRDINEATYS YLIVGFVSLM VAQLISNIIV TTYLIIKIKS
NPSSHIKKKG L
