ID   AYT1_YEAST              Reviewed;         474 AA.
AC   Q12226; D6VXU6;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Trichothecene 3-O-acetyltransferase;
DE            EC=2.3.1.-;
GN   Name=AYT1; OrderedLocusNames=YLL063C; ORFNames=L0549;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204511 / S288c / AB972;
RA   Wedler H., Wambutt R.;
RT   "Sequence of a 37 kb DNA fragment from chromosome XII of Saccharomyces
RT   cerevisiae including the subtelomeric region of the left arm.";
RL   Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169871;
RA   Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA   Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA   Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA   Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA   Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA   Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA   Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA   Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA   Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA   Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA   Zollner A., Hani J., Hoheisel J.D.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL   Nature 387:87-90(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   FUNCTION.
RX   PubMed=12478589; DOI=10.1002/yea.924;
RA   Alexander N.J., McCormick S.P., Hohn T.M.;
RT   "The identification of the Saccharomyces cerevisiae gene AYT1(ORF-YLL063c)
RT   encoding an acetyltransferase.";
RL   Yeast 19:1425-1430(2002).
RN   [5]
RP   FUNCTION.
RX   PubMed=15699200; DOI=10.1099/mic.0.27435-0;
RA   Tokai T., Fujimura M., Inoue H., Aoki T., Ohta K., Shibata T.,
RA   Yamaguchi I., Kimura M.;
RT   "Concordant evolution of trichothecene 3-O-acetyltransferase and an rDNA
RT   species phylogeny of trichothecene-producing and non-producing fusaria and
RT   other ascomycetous fungi.";
RL   Microbiology 151:509-519(2005).
CC   -!- FUNCTION: Trichothecene 3-O-acetyltransferase involved in self-
CC       protection against trichothecenes, mycotoxins acting as eukaryotic
CC       protein synthesis inhibitors. Its existence is surprising in a non-
CC       trichothecene producer organism which needs no self-protection again
CC       endogenic trichothecenes. The persistence of this non-essential gene
CC       may be due to a selective advantage that it may confer, like a
CC       resistance to exogenic trichothecenes. {ECO:0000269|PubMed:12478589,
CC       ECO:0000269|PubMed:15699200}.
CC   -!- SIMILARITY: Belongs to the trichothecene 3-O-acetyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; Z47973; CAA87994.1; -; Genomic_DNA.
DR   EMBL; Z73168; CAA97516.1; -; Genomic_DNA.
DR   EMBL; BK006945; DAA09262.1; -; Genomic_DNA.
DR   PIR; S50957; S50957.
DR   RefSeq; NP_013037.1; NM_001181883.1.
DR   AlphaFoldDB; Q12226; -.
DR   SMR; Q12226; -.
DR   BioGRID; 31253; 33.
DR   IntAct; Q12226; 1.
DR   MINT; Q12226; -.
DR   STRING; 4932.YLL063C; -.
DR   CarbonylDB; Q12226; -.
DR   PaxDb; Q12226; -.
DR   PRIDE; Q12226; -.
DR   EnsemblFungi; YLL063C_mRNA; YLL063C; YLL063C.
DR   GeneID; 850663; -.
DR   KEGG; sce:YLL063C; -.
DR   SGD; S000003986; AYT1.
DR   VEuPathDB; FungiDB:YLL063C; -.
DR   eggNOG; ENOG502SHVS; Eukaryota.
DR   HOGENOM; CLU_026450_5_0_1; -.
DR   InParanoid; Q12226; -.
DR   OMA; AGICLRD; -.
DR   BioCyc; YEAST:YLL063C-MON; -.
DR   PRO; PR:Q12226; -.
DR   Proteomes; UP000002311; Chromosome XII.
DR   RNAct; Q12226; protein.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IBA:GO_Central.
DR   GO; GO:0045462; F:trichothecene 3-O-acetyltransferase activity; IMP:SGD.
DR   GO; GO:0043387; P:mycotoxin catabolic process; IMP:SGD.
DR   Gene3D; 3.30.559.10; -; 2.
DR   InterPro; IPR023213; CAT-like_dom_sf.
PE   3: Inferred from homology;
KW   Acyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..474
FT                   /note="Trichothecene 3-O-acetyltransferase"
FT                   /id="PRO_0000076181"
SQ   SEQUENCE   474 AA;  52837 MW;  0576D77357607F5C CRC64;
     MFRVKIISQK RTKSVQMLEN DQLDILGQQP SLYKLYTQIC SIYRVPDPSA HDHIVNTLTR
     GLETLAKNFQ WLAGNVVNEG ADEGNTGTYR IVPSDKIPLI VQDLREDLSA PTMDSLEKAD
     FPIYMLDEKT FAPCMTINPP GNTIGMAAKS GPVFAVQANF ISGGLVLTIV GQHNIMDITG
     QESIINLLNK SCHQKPFSDE ELLIGNIDKS KSIPLFDETW EPDTTLVHEI VETSRNTSGE
     EKEQSCSSNS TWAYVEFSAI SLQNLRILAM QTCTSGTKFV STDDIVTAFI WKSVSRARLS
     RLKPETKSNL GRAVDVRKRL GLPETYPGLL VNMTFNTGSL KSLDHKSLGV LASQIRRKLD
     PKVFDLAYNT CALATLLSRC PDKTKVSIPQ PIDTLSGIMV SSWAKVSLYD VDFNLGLGKP
     KSVRRPRFIS LESLIYFMPR SSRGEMVVAL CLRDKDWECL NADKEWTNYA THIG