AZF3_ARATH
ID AZF3_ARATH Reviewed; 193 AA.
AC Q9SSW0; Q8L8P4;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Zinc finger protein AZF3;
DE AltName: Full=Zinc-finger protein 3;
GN Name=AZF3; Synonyms=ZF3; OrderedLocusNames=At5g43170; ORFNames=MMG4.21;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=cv. Columbia;
RX PubMed=10806347; DOI=10.1016/s0378-1119(00)00133-5;
RA Sakamoto H., Araki T., Meshi T., Iwabuchi M.;
RT "Expression of a subset of the Arabidopsis Cys(2)/His(2)-type zinc-finger
RT protein gene family under water stress.";
RL Gene 248:23-32(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9501997; DOI=10.1093/dnares/4.6.401;
RA Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence
RT features of the regions of 1,191,918 bp covered by seventeen physically
RT assigned P1 clones.";
RL DNA Res. 4:401-414(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=15333755; DOI=10.1104/pp.104.046599;
RA Sakamoto H., Maruyama K., Sakuma Y., Meshi T., Iwabuchi M., Shinozaki K.,
RA Yamaguchi-Shinozaki K.;
RT "Arabidopsis Cys2/His2-type zinc-finger proteins function as transcription
RT repressors under drought, cold, and high-salinity stress conditions.";
RL Plant Physiol. 136:2734-2746(2004).
RN [7]
RP SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=21852415; DOI=10.1104/pp.111.182683;
RA Kodaira K.S., Qin F., Tran L.S., Maruyama K., Kidokoro S., Fujita Y.,
RA Shinozaki K., Yamaguchi-Shinozaki K.;
RT "Arabidopsis Cys2/His2 zinc-finger proteins AZF1 and AZF2 negatively
RT regulate abscisic acid-repressive and auxin-inducible genes under abiotic
RT stress conditions.";
RL Plant Physiol. 157:742-756(2011).
CC -!- FUNCTION: Transcriptional repressor probably involved in abiotic stress
CC responses. Binds DNA in a sequence-specific manner and can repress the
CC transactivation activity of other transcription factors.
CC {ECO:0000269|PubMed:15333755}.
CC -!- INTERACTION:
CC Q9SSW0; Q7G8V2: ARR15; NbExp=2; IntAct=EBI-1807790, EBI-1100967;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15333755,
CC ECO:0000269|PubMed:21852415}.
CC -!- TISSUE SPECIFICITY: Expressed in roots. {ECO:0000269|PubMed:10806347,
CC ECO:0000269|PubMed:15333755}.
CC -!- INDUCTION: By abscisic acid (ABA), ethylene, salt, cold and heat.
CC {ECO:0000269|PubMed:10806347, ECO:0000269|PubMed:15333755,
CC ECO:0000269|PubMed:21852415}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB030732; BAA85109.1; -; Genomic_DNA.
DR EMBL; AB008267; BAB08281.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94918.1; -; Genomic_DNA.
DR EMBL; BT024582; ABD42980.1; -; mRNA.
DR EMBL; AY088887; AAM67193.1; -; mRNA.
DR RefSeq; NP_199131.1; NM_123683.2.
DR AlphaFoldDB; Q9SSW0; -.
DR BioGRID; 19584; 7.
DR IntAct; Q9SSW0; 4.
DR STRING; 3702.AT5G43170.1; -.
DR PaxDb; Q9SSW0; -.
DR PRIDE; Q9SSW0; -.
DR EnsemblPlants; AT5G43170.1; AT5G43170.1; AT5G43170.
DR GeneID; 834334; -.
DR Gramene; AT5G43170.1; AT5G43170.1; AT5G43170.
DR KEGG; ath:AT5G43170; -.
DR Araport; AT5G43170; -.
DR TAIR; locus:2167766; AT5G43170.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_059471_1_2_1; -.
DR InParanoid; Q9SSW0; -.
DR OMA; FNGVEQW; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9SSW0; -.
DR PRO; PR:Q9SSW0; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9SSW0; baseline and differential.
DR Genevisible; Q9SSW0; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; ISS:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0042538; P:hyperosmotic salinity response; IEP:TAIR.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:TAIR.
DR GO; GO:0009409; P:response to cold; IEP:TAIR.
DR InterPro; IPR044653; AZF1/2/3-like.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45988; PTHR45988; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..193
FT /note="Zinc finger protein AZF3"
FT /id="PRO_0000421828"
FT ZN_FING 75..97
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 118..140
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 70
FT /note="A -> E (in Ref. 5; AAM67193)"
FT /evidence="ECO:0000305"
FT CONFLICT 105
FT /note="E -> D (in Ref. 5; AAM67193)"
FT /evidence="ECO:0000305"
FT CONFLICT 170
FT /note="I -> L (in Ref. 5; AAM67193)"
FT /evidence="ECO:0000305"
FT CONFLICT 177
FT /note="P -> R (in Ref. 5; AAM67193)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 193 AA; 21020 MW; DE67FEB17AAA51CA CRC64;
MALEALNSPR LVEDPLRFNG VEQWTKCKKR SKRSRSDLHH NHRLTEEEYL AFCLMLLARD
GGDLDSVTVA EKPSYKCGVC YKTFSSYQAL GGHKASHRSL YGGGENDKST PSTAVKSHVC
SVCGKSFATG QALGGHKRCH YDGGVSNSEG VGSTSHVSSS SHRGFDLNII PVQGFSPDDE
VMSPMATKKP RLK
