ID   AZI2_BOVIN              Reviewed;         393 AA.
AC   Q3SYW5;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=5-azacytidine-induced protein 2;
GN   Name=AZI2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein which binds TBK1 and IKBKE playing a role in
CC       antiviral innate immunity (By similarity). Activates serine/threonine-
CC       protein kinase TBK1 and facilitates its oligomerization (By
CC       similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit
CC       RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF-
CC       alpha or PMA-induced activation of NF-kappa-B (By similarity).
CC       Participates in IFNB promoter activation via TICAM1 (By similarity).
CC       {ECO:0000250|UniProtKB:Q9H6S1}.
CC   -!- SUBUNIT: Homodimer (By similarity). Interacts with IKBKE, TBK1 and
CC       TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9H6S1,
CC       ECO:0000250|UniProtKB:Q9QYP6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H6S1}.
CC   -!- PTM: Ubiquitinated via 'Lys-48'-linked polyubiquitination by TRIM38,
CC       leading to its degradation. {ECO:0000250|UniProtKB:Q9QYP6}.
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DR   EMBL; BC103353; AAI03354.1; -; mRNA.
DR   RefSeq; NP_001070473.1; NM_001077005.2.
DR   RefSeq; XP_015314944.1; XM_015459458.1.
DR   AlphaFoldDB; Q3SYW5; -.
DR   SMR; Q3SYW5; -.
DR   STRING; 9913.ENSBTAP00000005379; -.
DR   PaxDb; Q3SYW5; -.
DR   PRIDE; Q3SYW5; -.
DR   Ensembl; ENSBTAT00000005379; ENSBTAP00000005379; ENSBTAG00000004117.
DR   GeneID; 767932; -.
DR   KEGG; bta:767932; -.
DR   CTD; 64343; -.
DR   VEuPathDB; HostDB:ENSBTAG00000004117; -.
DR   VGNC; VGNC:26368; AZI2.
DR   eggNOG; ENOG502QV07; Eukaryota.
DR   GeneTree; ENSGT00940000153704; -.
DR   HOGENOM; CLU_059745_0_0_1; -.
DR   InParanoid; Q3SYW5; -.
DR   OMA; PWPSQSC; -.
DR   OrthoDB; 1268120at2759; -.
DR   TreeFam; TF331289; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000004117; Expressed in oviduct epithelium and 109 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0097028; P:dendritic cell differentiation; IEA:Ensembl.
DR   GO; GO:0044565; P:dendritic cell proliferation; IEA:Ensembl.
DR   GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0042110; P:T cell activation; IEA:Ensembl.
DR   InterPro; IPR024581; TBD.
DR   Pfam; PF12845; TBD; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Phosphoprotein; Reference proteome;
KW   Ubl conjugation.
FT   CHAIN           1..393
FT                   /note="5-azacytidine-induced protein 2"
FT                   /id="PRO_0000280601"
FT   REGION          1..198
FT                   /note="Homodimerization"
FT                   /evidence="ECO:0000250"
FT   REGION          217..258
FT                   /note="Interaction with TBK1 and IKBKE"
FT                   /evidence="ECO:0000250"
FT   REGION          321..340
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          345..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          40..198
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        345..365
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         319
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q4KMA0"
FT   MOD_RES         354
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6S1"
SQ   SEQUENCE   393 AA;  44917 MW;  72EA5FCDBC808510 CRC64;
     MDALVEDDIC ILNHEKAHRR DPVTPVSIYS GDESVASHFA LVTAYEDIKK RLKDSEKENS
     FLKKRIRILE EKLIGARKDE ETSSVGREQV NKAYHAYREV CIDRDNLKSK LDKMNKDNSE
     SLKVLNEQLQ SKEVELLQLR TEVETQQVIR NLNPPSSNWE VEKLSCDLKI HGLEQELELL
     RKECRDLRIE LQKAKQTDPS LDDNLNCRDL QRLSVSSDNM QSAYWELKRE MSNLHLVTQV
     QAELLRKLKT PAAIKKACAP AGCMEDLGKD STKLHLSNFT AAYKRHAPLS PNGKTLCHAT
     PSPLPGDAKV LSEKAALQSW TDHERSIPHD GTNFQEHNSY SRNSLEDNSW VFPSPPKSSE
     TTFGEMKSKP LPLPNLPPLH YLDQHNQNCH YKH