ID   AZI2_PONAB              Reviewed;         392 AA.
AC   Q5RD40;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=5-azacytidine-induced protein 2;
GN   Name=AZI2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein which binds TBK1 and IKBKE playing a role in
CC       antiviral innate immunity (By similarity). Activates serine/threonine-
CC       protein kinase TBK1 and facilitates its oligomerization (By
CC       similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit
CC       RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF-
CC       alpha or PMA-induced activation of NF-kappa-B (By similarity).
CC       Participates in IFNB promoter activation via TICAM1 (By similarity).
CC       {ECO:0000250|UniProtKB:Q9H6S1}.
CC   -!- SUBUNIT: Homodimer (By similarity). Interacts with IKBKE, TBK1 and
CC       TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9H6S1,
CC       ECO:0000250|UniProtKB:Q9QYP6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H6S1}.
CC   -!- PTM: Ubiquitinated via 'Lys-48'-linked polyubiquitination by TRIM38,
CC       leading to its degradation. {ECO:0000250|UniProtKB:Q9QYP6}.
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DR   EMBL; CR858078; CAH90317.1; -; mRNA.
DR   RefSeq; NP_001127269.1; NM_001133797.1.
DR   AlphaFoldDB; Q5RD40; -.
DR   SMR; Q5RD40; -.
DR   STRING; 9601.ENSPPYP00000015723; -.
DR   GeneID; 100174325; -.
DR   KEGG; pon:100174325; -.
DR   CTD; 64343; -.
DR   eggNOG; ENOG502QV07; Eukaryota.
DR   InParanoid; Q5RD40; -.
DR   OrthoDB; 1268120at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR024581; TBD.
DR   Pfam; PF12845; TBD; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Phosphoprotein; Reference proteome;
KW   Ubl conjugation.
FT   CHAIN           1..392
FT                   /note="5-azacytidine-induced protein 2"
FT                   /id="PRO_0000280605"
FT   REGION          1..197
FT                   /note="Homodimerization"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QYP6"
FT   REGION          216..257
FT                   /note="Interaction with TBK1 and IKBKE"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6S1"
FT   REGION          345..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          40..76
FT                   /evidence="ECO:0000255"
FT   COILED          102..135
FT                   /evidence="ECO:0000255"
FT   COILED          166..196
FT                   /evidence="ECO:0000255"
FT   MOD_RES         318
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q4KMA0"
FT   MOD_RES         353
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6S1"
SQ   SEQUENCE   392 AA;  44835 MW;  90ABA90F40B66368 CRC64;
     MDALVEDDIC ILNHEKAHKR DTVTPVSIYS GDESVASHFA LVTAYEDIKK RLKDSEKENS
     LLKKRIRFLE EKLIARFDEE TSSVGREQVN KAYHAYREVC IDRDNLKSKL DKMNKDNSES
     LKVLNEQLQS KEVELLQPRT EVETQQVMRN LNPPSSNWEV EKLSCDLKIH GLEQELELMR
     KECSDLKIEL QKAKQTDPYQ EDNLKSRDLQ KLSISSDNMQ HAYWELKREM SNLHLVTQVQ
     AELLRKLKTS TAIKKACAPV GCSEDLGRDS TKLHLMNFTA TYTRHPPVSP NGKALCHTAS
     SPLPGDVKVL SEKAILQSWT DNERSIPNDG TCFQEHSSYG RNSLEDNSWV FPSPPKSSET
     AFGETKTKTL PLPNLPPLHY LDQHNQNCLY KN