AZLC_BACSU
ID AZLC_BACSU Reviewed; 254 AA.
AC O07942;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Branched-chain amino acid transport protein AzlC;
GN Name=azlC; Synonyms=yrdH; OrderedLocusNames=BSU26710;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / BGSC1A1;
RX PubMed=9287000; DOI=10.1128/jb.179.17.5448-5457.1997;
RA Belitsky B.R., Gustafsson M.C.U., Sonenshein A.L., von Wachenfeldt C.;
RT "An lrp-like gene of Bacillus subtilis involved in branched-chain amino
RT acid transport.";
RL J. Bacteriol. 179:5448-5457(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9308178; DOI=10.1099/00221287-143-9-2939;
RA Sorokin A., Bolotin A., Purnelle B., Hilbert H., Lauber J.,
RA Duesterhoeft A., Ehrlich S.D.;
RT "Sequence of the Bacillus subtilis genome region in the vicinity of the lev
RT operon reveals two new extracytoplasmic function RNA polymerase sigma
RT factors SigV and SigZ.";
RL Microbiology 143:2939-2943(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- FUNCTION: Involved in branched-chain amino acid transport.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the AzlC family. {ECO:0000305}.
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DR EMBL; Y11043; CAA71940.1; -; Genomic_DNA.
DR EMBL; U93876; AAB80901.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14612.1; -; Genomic_DNA.
DR PIR; G69592; G69592.
DR RefSeq; NP_390548.1; NC_000964.3.
DR RefSeq; WP_009969035.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; O07942; -.
DR STRING; 224308.BSU26710; -.
DR TCDB; 2.A.78.1.1; the branched chain amino acid exporter (liv-e) family.
DR PaxDb; O07942; -.
DR PRIDE; O07942; -.
DR EnsemblBacteria; CAB14612; CAB14612; BSU_26710.
DR GeneID; 936606; -.
DR KEGG; bsu:BSU26710; -.
DR PATRIC; fig|224308.179.peg.2901; -.
DR eggNOG; COG1296; Bacteria.
DR InParanoid; O07942; -.
DR OMA; DFAFPAV; -.
DR PhylomeDB; O07942; -.
DR BioCyc; BSUB:BSU26710-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR InterPro; IPR004471; Brnchd-chn_aa_trnsp_AzlC.
DR InterPro; IPR011606; Brnchd-chn_aa_trnsp_permease.
DR PANTHER; PTHR34979; PTHR34979; 1.
DR Pfam; PF03591; AzlC; 1.
DR TIGRFAMs; TIGR00346; azlC; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..254
FT /note="Branched-chain amino acid transport protein AzlC"
FT /id="PRO_0000111780"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 254 AA; 28366 MW; 1463E390B0054B45 CRC64;
MNKNKESLHL SSPAINTHMN KRSQIWAAFR SAFPYTIPIF AGFLFLGIAY GIFMHSLGFS
AIYPIIMSFM IFAGSMEFVA ANFLLGAFNP MNALFLTLMV NARHLFYGIS MLDKYRGTGK
KKLYLIFGMC DESFSINYTA NVPANVDKGW FMFFVTLLNH LYWVAGAAIG GIFGSYVKFN
TEGLDFVMTA LFIVIFIEQW MKEKKHYSAL TGLGLSVASL ILFGGNQFII PAMLAILGVL
TVLRKPLEKA EVSV
