AZO1_STAAC
ID AZO1_STAAC Reviewed; 188 AA.
AC Q5HIB5;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=FMN-dependent NADPH-azoreductase;
DE EC=1.7.-.-;
DE AltName: Full=NADPH-dependent flavo-azoreductase;
DE AltName: Full=NADPH-flavin azoreductase;
GN Name=azo1; OrderedLocusNames=SACOL0607;
OS Staphylococcus aureus (strain COL).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93062;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COL;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- FUNCTION: Catalyzes the reductive cleavage of azo bond in aromatic azo
CC compounds to the corresponding amines. Requires NADPH, but not NADH, as
CC an electron donor for its activity (By similarity). {ECO:0000250}.
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000250};
CC -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the azoreductase type 2 family. {ECO:0000305}.
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DR EMBL; CP000046; AAW37716.1; -; Genomic_DNA.
DR RefSeq; WP_000677261.1; NC_002951.2.
DR AlphaFoldDB; Q5HIB5; -.
DR SMR; Q5HIB5; -.
DR EnsemblBacteria; AAW37716; AAW37716; SACOL0607.
DR KEGG; sac:SACOL0607; -.
DR HOGENOM; CLU_055322_1_2_9; -.
DR OMA; PEYHSGM; -.
DR Proteomes; UP000000530; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.360; -; 1.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR005025; FMN_Rdtase-like.
DR Pfam; PF03358; FMN_red; 1.
DR SUPFAM; SSF52218; SSF52218; 1.
PE 3: Inferred from homology;
KW Flavoprotein; FMN; NADP; Oxidoreductase.
FT CHAIN 1..188
FT /note="FMN-dependent NADPH-azoreductase"
FT /id="PRO_0000245991"
SQ SEQUENCE 188 AA; 20912 MW; D7CA1764A344D641 CRC64;
MKGLIIIGSA QVNSHTSALA RYLTEHFKTH DIEAEIFDLA EKPLNQLDFS GTTPSIDEIK
QNMKDLKEKA MAADFLILGT PNYHGSYSGI LKNALDHLNM DYFKMKPVGL IGNSGGIVSS
EPLSHLRVIV RSLLGIAVPT QIATHDSDFA KNEDGSYYLN DSEFQLRARL FVDQIVSFVN
NSPYEHLK